Bone tissue regeneration guiding membrane and preparation method thereof

Abstract

A bone tissue regeneration guiding membrane. The invention employs an antigen-extracted mammal tissue membrane, which has a double layer structure of a compact layer and a loosening layer. The compact layer is formed by tightly arranged collagen fibers, and an external side of the compact layer is composited with a collagen coating containing active polypeptides; the loosening layer is formed by interlaced collagen fibers and is composited with ossification active factors. The prepared guiding membrane can prevent soft tissue from evolving and promote new bone formation, has good biological compatibility, hydrophilism and bone induction capability, and can be completely degraded in body without generation of harmful substances. Besides, the guiding membrane has an effect of isolating cell evolving, a characteristic of slow degradation and a longer retaining time in body than a current guiding membrane prepared from natural high-molecular polymer, and can provide enough time and space for new bone growth. The method of the invention is simple, and raw materials have wide sources and low prices, so that the method is suitable for large-scale industrial production and beneficial to lowering medical costs and mitigating patient burdens.

Description

technical field [0001] The invention belongs to the technical field of medical biomaterials, and in particular relates to a biofilm material capable of guiding bone tissue regeneration and a preparation method thereof. Background technique [0002] Membrane-guided tissue regeneration (guided tissue regeneration, GTR) technology has been widely used in the field of bone tissue repair. Its principle is to prevent soft tissue cells from entering the bone growth area through the physical barrier effect of the membrane material, and to prevent new bone growth in the bone defect area. Leave space and guide osteoblasts to generate new bone in the bone defect area. [0003] The membrane used in the early stage of GTR technology is not absorbable in the body. For example, the GTR membrane made of polytetrafluoroethylene must be taken out by a second operation when it is used, which brings great pain to the patient, and because it has no biological activity, it cannot be used for rela...

AI Technical Summary

Problems solved by technology

However, the mechanical properties and water resistance of the guide membrane made of natural polymers are poor, and the degradation is too fast, which does not match the growth rate of bone tissue.

Chinese patent application 200410071932.1 discloses a double-layer collagen-based guided tissue regeneration material and its preparation method. In order to overcome the defect that the collagen material degrades too quickly, it uses a chemical cross-linking agent to improve the degradation resistance of the material and prolong the regenerative membrane in vivo. Degradation time; due to the residue of chemical cross-linking agents such as glutaraldehyde in the product will cause the rejection of the product by the patient's body, and its preparation method is complicated and requires high equipment conditions, which increases the cost and makes large-scale production difficult.

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