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101 results about "Small intestinal mucosa" patented technology

Preparation of medical bioavailability bracket material and uses thereof

ActiveCN101185774AProsthesisDiseasePorosity
The invention relates to a preparation and using method of medical biocompatible stent material. The medical biocompatible stent material is prepared by applying the small intestine submucosal and the tendon tissue of people or animals as the raw materials. The invention has good biocompatibility, appropriate porosity and mechanical strength and stable spatial structure, and the invention contains various growth factors to induce the tissue for regeneration and reconstruction, thereby improving the success rate of the repair of the various tissue defects and the reconstruction of tissue structures, therefore, the invention is an ideal tissue engineering material. The medical biocompatible stent material which is provided by the invention is applicable to the preparation of various tissue engineering equipments and the application in the repair of various tissue defects and injuries, including skin, blood vessels, nerves, tendons, bones, cartilages, abdominal walls, urinary tracts, oral mucosa and so on, and the invention can be used in the treatment of trauma, abdominal external hernia, anal fistula, rectovaginal fistula, rectum anterior protrusion, bone and cartilage defects, vascular injuries, nerve injuries, tendon injuries, oral mucosal injuries, relaxed pelvic floor, urinary tract injuries and other diseases.
Owner:BEIJING BIOSIS HEALING BIOLOGICAL TECH

Compound frequently combined ultrasonic reinforced double-enzyme heparin sodium extracting technique

The invention relates to a heparin sodium technique, in particular to a heparin sodium extracting technique utilizing multi-frequency combination and ultrasonic double-enzyme reinforcement. Firstly, the scraped small intestinal mucosa is sucked in a conventional enzymolysis vessel, and refined salt with a proportion of 2.3 percent to 2.8 percent by weight is firstly added thereto before heating, and the pH value is adjusted to 9.0 to 9.2; secondly, when the solution obtained from the first step is heated to 40 DEG C to 45 DEG C, trypsase and lipase are added, and the proportion is maintained between 10 : 0.5 to 10 : 5, the weight proportion of the double enzyme in the solution in the first step accounts for 0.3 percent to 0.4 percent, the solution is continuously heated to 50 DEG C to 55 DEG C, the enzymolysis under heat preservation is performed for 2 hours to 5 hours, then the solution is continuously heated to 80 DEG C to 85 DEG C, and the solution is filtered after being insulated for 10 minutes to 20 minutes; and thirdly, the filtered solution obtained from the second step is treated through the conventional steps of adsorbing, washing, eluting, precipitating, dehydrating and drying, so as to obtain the heparin sodium product. Compared with the prior art, the invention has the advantages that: firstly, the entire procedure time is substantially reduced by 33 percent; secondly, the yield of products is increased by 29.6 percent; and thirdly, the titer is stabilized to be higher than 120 (the titer of the domestic advanced technology product is between 90 and 110).
Owner:罗时通

Preparation method and application of biological nanopatch

The invention discloses a method for preparing a biological nanopatch constructed by astragaloside induced BMSC compound polylactic acid-glycolic acid nano-particle modified small intestinal submucosa matrix. The method comprises the following steps: preparing polylactic acid-glycolic acid nano-particles (PLGA) by adopting a multiple emulsion method; preparing a small intestinal submucosa matrix (SIS) having a natural three-dimensional ultra micro-structure by adopting a decellation technology to adsorb the PLGA nano-particles on the surface of SIS and favor adsorption and growth of host cells by means of the SIS after PLGA nano-particle surface modification; inducing BMSC by astragaloside to promote proliferation and differentiation of BMSC and enable the BMSC to compound and grow on the PLGA nano-particle surface modified small intestinal submucosa matrix (PLGA-SIS) of pigs. Therefore, the AS-BMSC-PLGA-SIS biological patch has stable physicochemical property, good biocompatibility and high mechanical strength, and is beneficial to tissue regeneration.
Owner:HANGHZOU HOSPITAL OF TRADITIONAL CHINESE MEDICINE

Small intestinal mucosa scraping device

The utility model relates to a small intestinal mucosa scraping device, and relates to an intestinal scraping machine. A rectangular structure is enclosured by two horizontal bars and two longitudinalbars, one horizontal bar has a plurality of fixing clamps, and each longitudinal bar is externally provided with a ring sleeve; the two horizontal bars are connected with both ends of a ball screw, the ball screw is connected with a stepping motor, and the stepping motor is connected with the horizontal bars; the ball screw has a ball screw mother, and rectangular frames exist between the ball screw mother and the two ring sleeves; the inner bottom face of each rectangular frame is connected with a lower scraper, the inner top face of each rectangular frame is connected with an upper scraperthrough a spring, and the upper scrapers are matched with the lower scrapers correspondingly. Through holes are formed in the middle part of the upper end of each rectangular frame, and thread holes corresponding to the through holes are formed in the middle of each upper scraper; the lower ends of limit screws separately interstitially pass through the corresponding through holes and then are connected with the corresponding thread holes in a threaded manner. The problem that the prior art cannot simultaneously scrape mucosa and maintain intestinal integrity is solved.
Owner:NORTHEAST AGRICULTURAL UNIVERSITY

Method for producing heparin sodium by using membrane and resin column

The invention discloses a method for producing heparin sodium by using a membrane and a resin column, and belongs to the technical field of heparin sodium production. In order to solve the problems oflong consumed time, low product yield, difficult treatment of enzymatic hydrolysate and the like in the existing heparin sodium enzymolysis process, the method comprises the following steps: carryingout enzymolysis on small intestinal mucosa of pigs, coarsely filtering the enzymatic hydrolysate, and then filtering by using a microfiltration membrane to obtain intestinal residues, trapped fluid and dialysate; filtering the dialysate by using a nanofiltration membrane to obtain trapped fluid and dialysate; adsorbing the trapped fluid by using resin, and washing and desorbing the resin by usingsaline water after adsorption to obtain adsorbed residual liquid, washing liquid and desorbed liquid; filtering the desorbed solution by using a nanofiltration membrane to obtain trapped fluid and dialysate; and precipitating the trapped fluid with ethanol, collecting the precipitate, dehydrating, and drying to obtain heparin sodium. According to the method, heparin is adsorbed faster and more, adsorption adopts a resin column for adsorption, and compared with adsorption of an adsorption tank, the method has the advantages of less resin consumption, short adsorption time and high adsorption rate.
Owner:丰润生物科技股份有限公司 +1

Chinese herbal compound for preventing and treating porcine epidemic diarrhea virus

The invention discloses a Chinese herbal compound for preventing and treating porcine epidemic diarrhea virus, comprising: preparing Herba Phyllanthi Urinariae, Herba Origani Vulgaris and Herba Salviae Plebeiae into powder according to a weight ratio of 3:2:1, mixing the powder and feed according to a weight ratio of 1:100, and feeding a diseased pig; or adding distilled water 10 times as heavy as the powder, soaking for 1 h before 1 h of heating and refluxing, filtering with gauze while temperature is high, adding water 8 time as heavy as residue and water 6 times as heavy as the residue respectively to the residue for 1 h of heating and refluxing, combining three filtrates, concentrating under reduced pressure to obtain liquid medicine 1 g/mL in concentration, and intramuscularly injecting the diseased pig. TFF3 content can be significantly increased, thus improving mucosal defensive function of animal small intestines, decreasing NO level, improving intestinal peristalsis and intestinal juice electrolyte balance, enhancing animal physique, and decreasing bodily urea level can be decreased; ALB level can be significantly increased to improve bodily liver metabolism, GLO level can be significantly increased to enhance body immunity.
Owner:JIANGSU ACADEMY OF AGRICULTURAL SCIENCES

Method for preparing crude heparin sodium from porcine small intestine mucous membrane with low salt

The invention provides a method for preparing crude heparin sodium from porcine small intestine mucosa with low salt. The method comprises the following steps: carrying out low-salt composite enzymolysis to obtain an enzymatic hydrolysate, concentrating the enzymatic hydrolysate to obtain a concentrated solution, carrying out ion exchange to obtain a crude heparin sodium eluent, carrying out alcohol precipitation, and performing drying to obtain the crude heparin sodium, to be specific, adding saturated casingsaline water in thelow-salt composite enzymolysis; and adjusting the salt concentration of the mucous membrane solution to 0.8-1.0% by mass. According to the method for preparing the crude heparin sodium from the porcine small intestine mucous membrane in the low-salt mode, enzymolysis and adsorption processes of the crude heparin sodium can be achieved under the low-salt condition, the salt concentration in discharged wastewater can be reduced while the yield of the crude heparinsodium is guaranteed, the wastewater treatment cost is reduced, environmental pollution is reduced, and comprehensive economic benefits are increased.
Owner:河北常山凯库得生物技术有限公司

Feeding method capable of improving growth performance of broiler chicken 1-21 days old

The invention belongs to the technical field of chicken cultivation and in particular relates to a feeding method capable of improving growth performance of broiler chicken 1-21 days old. The feeding method comprises the following concrete steps: (1) feeding young chicken with feed everyday, namely feeding the young chicken with feed for five times everyday; and (2) feeding the young chicken with nutrient solution everyday, namely feeding the young chicken with the nutrient solution twice everyday. The feeding method provided by the invention has the advantages that content of proteins, DNA and RNA of intestinal mucosae is increased, intestinal villi are heightened, intestinal walls are thickened, small intestinal mucosa enzyme activity is improved, intestinal development is further promoted, growth of the intestinal villi is promoted, villi are heightened, and recesses are shallowed, so that quantity of mature cells of intestinal epitheliums is increased, and maturation rate is increased, capability of digesting and absorbing nutrient substances is enhanced, feed utilization rate is improved, and the broiler chicken can be grown rapidly; meanwhile, metabolism of microorganisms is accelerated, structure of a flora is adjusted, intestinal microecological balance is effectively maintained, intestinal conditioned pathogens are inhibited, nutrition is provided, body immunity is enhanced, and robust growth of the young chicken is promoted.
Owner:JIESHOU DONGYONG ANIMAL HUSBANDRY
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