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46 results about "Decellularized matrix" patented technology
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Decellularized matrix-source tissue engineering scaffold and preparation method and application thereof
InactiveCN105935454AImprove mechanical propertiesGood biocompatibilityPharmaceutical delivery mechanismTissue regenerationForeign matterAntigen
The invention relates to a decellularized matrix-source tissue engineering scaffold and a preparation method and an application thereof; the decellularized matrix-source tissue engineering scaffold takes a treated animal membrane material as a biological membrane base material, and the surface of the biological membrane base material is attached with a collagen loose layer. The preparation method of the decellularized matrix source tissue engineering scaffold comprises the process steps of degreasing, decellularizing, antigen removal, cross-linking fixation, collagen extraction, collagen compositing and the like. The flexible and smooth animal membrane material is used as the biological membrane base material, and the defects that a pure collagen scaffold has poor mechanical properties and too fast degradation rate are overcome; with cooperation of the collagen loose layer, a good microenvironment is provided for tissue regenerative repair and cell growth; after being implanted into a body, the decellularized matrix-source tissue engineering scaffold material is gradually degraded along with repairing of defect tissues, also has controllable degradation time, does not exist as a permanent foreign matter, and has no any residual toxicity.
Owner:广州市美昊生物科技有限公司 +1
Natural tissue-derived decellularized matrix and methods of generating and using same
ActiveUS9216236B2Maintain mechanical propertiesUnknown materialsCell culture supports/coatingCellular componentCell-Extracellular Matrix
Owner:TECHNION RES & DEV FOUND LTD
Natural Tissue-Derived Decellularized Matrix and Methods of Generating and Using Same
ActiveUS20150050247A1Maintain mechanical propertiesBiocideCell culture supports/coatingCellular componentDigestion
Decellularized tissue-derived extracellular matrices (ECM) and methods of generating and using same are provided. The method of generating a decellularized matrix includes the steps of: (a) subjecting the tissue to washes and a hypertonic buffer; (b) subjecting the tissue to an enzymatic proteolytic digestion with an enzyme such as trypsin; and (c) removing all cellular components from the tissue using a detergent solution which includes Triton-X-100 and ammonium hydroxide. Specifically, there is provided a decellularized myocardium-derived matrix which is completely devoid of all cellular components and hence non-immunogenic in a subject, exhibits suitable structural and mechanical properties for cardiac tissue engineering or replacement therapy of damaged cardiac tissue, and is capable of remodeling upon seeding of cells.
Owner:TECHNION RES & DEV FOUND LTD
Chitosan-heparin nano-particles and cell matrix-removed biomaterial processed by using the same
ActiveCN102477172AGood endothelialization propertiesSelf-replacementPharmaceutical containersMedical packagingAnti bacteriaBlood vessel
The invention relates to a chitosan nano-material, particularly a nano-material formed with heparin. The invention further relates to a cell matrix-removed biomaterial. The invention aims at providing chitosan-heparin nano-particles suitable for specific binding of vascular endothelial growth factor (VEGF) and heparin and capable of binding with the cell matrix-removed biomaterial. The biomaterial is prepared by using an ion cross-linking method. The biological valve-possessed duct for pulmonary artery vessel restoration or reconstruction provided by the invention has good endothelialization performance, antithrombotic performance, anti-bacteria performance, and long-term persistent curative effect, and is beneficial for self-replacement of the biological valve-possessed duct.
Owner:吴忠仕 +1
Preparation method of natural soft tissue decellularization matrix
InactiveCN107233621ABreach of integrityFacilitated releaseTissue regenerationProsthesisMedicineBiocompatibility Testing
The invention discloses a preparation method of a natural soft tissue decellularization matrix. The method includes material taking, pretreatment, disinfection, degreasing, enzyme treatment, decellularization, rinsing and sterilization. The method has the advantages of being high in decellularization efficiency, small in damage of matrix components, low in immunogenicity of the decellularization matrix, and good in biocompatibility.
Owner:GUANGZHOU SUN SHING BIOTECH CO LTD
Method for preparing the decellularized matrix
InactiveUS20110045566A1Increase speedIncrease biological functionHormonesElectrical/wave energy microorganism treatmentPhospholipaseOrganic chemistry
A method for preparing the decellularized matrix using the phospholipase includes the following steps: pretreating the standby tissue and organ; putting the standby tissue and organ into the solution containing the phospholipase; preparing the decellularized matrix in the control condition; washing the prepared decellularized matrix.
Owner:ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
Cardiac muscle tissue engineering product and its preparation method and use
The invention discloses a cardiac muscle tissue engineering product and its preparation method and use. The preparation method comprises 1, omentum majus decellularized matrix scaffold material preparation: immersing omentum majus in a decellularizing liquid containing lauryl sodium sulfate, DNA enzyme and trypsin so that decellularizing treatment is realized and 2, myocardial cell-omentum majus decellularized matrix complex construction and culture. The cardiac muscle tissue engineering product comprises the myocardial cell and omentum majus decellularized matrix scaffold material. The omentum majus decellularized matrix has a good 3D netted space structure and is rich in a growth factor so that myocardial cell growth and nutrient and metabolite transport are realized. The cardiac muscle tissue engineering product has an important meaning for cardiac muscle damage restoration based on the cardiac muscle tissue engineering product and cardiac muscle treatment drug screening utilizing the cardiac muscle tissue engineering product as a model.
Owner:北京帝康医药投资管理有限公司
Method for preparing soft tissue decellular matrix through supercritical fluid technology
InactiveCN107164298AIncrease the diffusion coefficientMass transfer speedBiological preparation purgeMuscle tissueBlood Vessel Tissue
The present invention discloses a preparation method of a soft tissue decellular matrix, and relates to the technical field of clinical medicine, biomedical medicine and regenerative medicine. According to the present invention, the natural soft tissue decellular matrix is prepared by using a supercritical fluid technology, wherein the natural soft tissue comprises small intestine tissue, blood vessel tissue, muscle tissue, heart tissue, valve tissue, lung tissue, spleen tissue, kidney tissue, liver tissue, stomach tissue, gallbladder tissue, fat tissue, cartilage tissue, trachea tissue, esophagus tissue, bladder tissue, ureter tissue, oviduct tissue, or uterus tissue. According to the present invention, with the preparation method, the damage on the soft tissue matrix component is low, and the obtained soft tissue decellular matrix has advantages of low immunogenicity and good biocompatibility.
Owner:GUANGZHOU SUN SHING BIOTECH CO LTD
Composite nanofiber pad, hydrogel/sponge dressing, preparation method and application
ActiveCN110124086AHigh strengthAct as an infectionPharmaceutical delivery mechanismAbsorbent padsComposite nanofibersBiocompatibility Testing
The invention discloses a composite nanofiber pad, a hydrogel / sponge dressing, a preparation method and application, and relates to the technical field of medical materials. The composite nanofiber pad comprises a receiving plate. A decellularized matrix and a high molecular material are compounded on the receiving plate, and the adding ratio of the decellularized matrix to the high molecular material is 1:1 to 1:6. The composite nanofiber pad is of a micro nanofiber structure. The hydrogel / sponge dressing can be used for loading components promoting regeneration and repair of wound surfaces,such as nutrients and drugs, hydrogel / sponge has high biocompatibility, and obvious cytotoxicity is avoided; the hydrogel / sponge dressing is soft, and can tightly cover all the wound surfaces to resist bacterial invasion and avoid wound infection.
Owner:SUN YAT SEN UNIV
Injectable hydrogel and preparation method thereof
ActiveCN110812529ABioinducibleControllable degradation ratePharmaceutical delivery mechanismProsthesisProtein solutionCell-Extracellular Matrix
The invention discloses an injectable hydrogel and a preparation method thereof. The preparation method comprises the following steps: sequentially performing cell crushing, primary proteolysis, cleaning, degreasing treatment and decellularization treatment on biological tissue so as to obtain a decellularized matrix, and performing freeze-drying on the decellularized matrix for later use; performing secondary proteolysis on the freeze-dried decellularized matrix so as to obtain a 6-40mg / mL water-soluble extracellular matrix protein solution; and crosslinking the extracellular matrix protein solution with 10-100mg / ml multi-arm modified polyethylene glycol containing a succinimide group, and / or a sulfydryl group, and / or a maleimide group and / or an amino group, so as to obtain the njectablehydrogel. The njectable hydrogel is prepared by using the method. The preparation method disclosed by the invention is simple, and the prepared hydrogel not only has the biological inductivity of collagen, but also has the property of controllable degradation rates of high polymer materials.
Owner:易小玉
Artificial blood vessel and preparation method thereof
ActiveCN106267369ASpread like AIDS withoutNo riskPharmaceutical containersMedical packagingSulfonateAutologous tissue
The invention discloses an artificial blood vessel and a preparation method thereof. Cell components of an autologous-tissue vessel are removed by adopting a 3-[(3-cholamidopropyl)-dimethylammonio]-1-propane sulfonate reagent chemical decellularization method; then heparin is combined to the surface of an autologous decellularized matrix vessel in a covalent binding manner, so as to obtain the artificial blood vessel. The artificial blood vessel prepared by the method has no immunogenicity; a preparation period is short and the cost is low; the artificial blood vessel can be prepared into different inner diameters and has a good anticoagulation function; a complicated in-vitro preparation process is not needed and the patency rate is high; cells can effectively enter a vessel wall to be reconstructed and the artificial blood vessel is completely better than previous allogenic or heterogeneous decellularized matrix vessels and has a very good clinical application prospect.
Owner:海迈医疗科技(苏州)有限公司
Microspheres Containing Decellularized Donor Tissue and Their Use in Fabricating Polymeric Structures
PendingUS20200289702A1Promote migrationIncreased proliferationAdditive manufacturing apparatusPeptide/protein ingredientsMicrosphereDonor tissue
Decellularized matrix microspheres comprising a polymeric material and a donor tissue are provided. Also disclosed are structures containing a plurality of decellularized matrix microspheres incorporating a first polymer and a donor tissue; and a second polymer, wherein the decellularized matrix microspheres and the second polymer are in the form of a filament. Methods of treating a tissue injury employing the matrix microspheres and structures described as well as their methods of manufacture are also provided.
Owner:CHILDRENS HOSPITAL MEDICAL CENT CINCINNATI +1
3D tissue engineering product containing living cells, and preparation method thereof
InactiveCN106166307ARich growth factorGrowth favors supportCulture processCell culture supports/coatingCell-Extracellular MatrixTissue material
The present invention provides a 3D tissue material, which adopts porcine small intestine mucosal decellularized matrix as a scaffold material, and is characterized by comprising cells, riboflavin or a derivative thereof. According to the present invention, the chemical components contained in the prepared 3D tissue material are highly close to the human extracellular matrix components, the prepared 3D tissue material is rich in growth factors, has good biocompatibility, and is favorable for cell growth; and the production process is simple, only the incandescent lamp is required to be adopted as the production equipment, the complex equipment is not required, the component harmful to the cell does not exist during the whole operation process, and the whole operation process cannot cause the environmental pollution.
Owner:CHONGQING ACAD OF ANIMAL SCI
Tissue engineering scaffold for urethra reconstruction and preparation method thereof
ActiveCN102488926BImprove mechanical propertiesRapid vascularizationCoatingsProsthesisFiberLong segment
The invention relates to a tissue engineering scaffold for urethra reconstruction and a preparation method thereof. The preparation method comprises the steps of: (1) preparing a regenerated silk fibroin aqueous solution; (2) preparing a vascular endothelial growth factor and bovine serum albumin aqueous solution; (3) mixing the solutions prepared in the steps (1) and (2) to prepare a regenerated silk fibroin solution containing the vascular endothelial growth factor; and (4) preparing the tissue engineering scaffold by adopting an electrostatic spinning technology with the solution prepared in the step (3) as a spinning liquid and a decellularized matrix as a base layer. According to the invention, the tissue engineering scaffold is of a double-layer structure composed of a decellularized matrix base layer and a functional layer, and the functional layer is a fibrofelt which is formed by regenerated silk fibroin fiber mixed with the vascular endothelial growth factor and bovine serum albumin and has a three-dimensional staggered network structure characteristic. The tissue engineering scaffold prepared by the method not only has excellent mechanical properties, but also can be early and quickly vascularized in vivo, and can be used for repairing long-segment urethrostenosis.
Owner:SHANGHAI SHUIXING HOME TEXTILE
Piezoelectric stent as well as preparation method and application thereof
ActiveCN112494723AImprove mechanical propertiesWith piezoresponseCapsule deliveryTissue regenerationMicrosphereBone tissue
The invention discloses a piezoelectric stent as well as a preparation method and application thereof, and the preparation method of the piezoelectric stent comprises the following steps: performing decellularization treatment on bone tissue organs, and then performing supercritical CO2 extraction to prepare a decellularized matrix with a three-dimensional porous structure; preparing drug-loaded microspheres; then mixing the drug-loaded microspheres with the decellularized matrix so as to enable the drug-loaded microspheres to cover the surface of the decellularized matrix and fill pores of the decellularized matrix, and carrying out heat preservation at 37-65 DEG C until the drug-loaded microspheres are bonded on the decellularized matrix so as to prepare a stent containing the drug-loaded microspheres; and then soaking the stent containing drug-loaded microspheres in a degradable piezoelectric polymer solution, taking out the stent for draining, and carrying out polarization treatment. The stent prepared by the preparation method of the piezoelectric stent can effectively delay the release rate of a drug, has osteogenic differentiation capacity and a piezoelectric response function, and can effectively promote repair and reconstruction of bone tissue.
Owner:GUANGDONG PROV MEDICAL INSTR INST
Acellular matrix particle product for soft tissue filling and repairing, and preparation method of acellular matrix particle product
PendingCN113769168AIncrease buoyancyIncrease elasticityTissue regenerationProsthesisAcellular matrixSubcutaneous tissue
Owner:江苏优创生物医学科技有限公司
Low-immunogenic bone defect part filling material and preparation method thereof
ActiveCN109529113AQuick fixGuaranteed recoveryTissue regenerationProsthesisAcellular matrixBone formation
The invention provides a low-immunogenic bone defect part filling material. The filling material is composed of aminated aloe polysaccharide-glyceraldehyde gel, heparin high affinity cytokine-entrapped heparin-poloxamer gel and a bone acellular matrix, and the mechanical strength and the degradation speed of the bone defect part filling material are controlled by changing the ratio of the components. The low-immunogenic bone defect part filling material overcomes the shortcomings and deficiencies of high immunogenicity in the prior art, provides a novel bone defect part filling material with low immunogenicity and multiple functions of bone conduction, bone induction, bone formation and mechanics support, provides the best physicochemical and biological micro-environments for bone regeneration, effectively guides the directional arraying of cells, has good mechanical properties, and can quickly repair bone defect parts.
Owner:WENZHOU MEDICAL UNIV
3D bioprinted skin tissue model
The present invention relates to a 3D bioprinted skin tissue model, a method for providing said model and the use of said model. The 3D bioprinted skin tissue model comprises at least one bioink A, at least one cell type A, at least one factor A, wherein the bioink A comprises at least one biopolymer, a thickener, at least one extra-cellular matrix or a decellularized matrix, and optionally a photo initiator and / or cellular additions, the at least one cell type A is an epidermal, dermal and / or hypodermal cell or cell line, and the at least one factor A is a growth factor, protein and / or molecule thatstimulates altered or abnormal metabolism of cell type A.
Owner:セルインクバイオプリンティングアーベー
Biological cornea prepared from swimming bladder as well as preparation method and application of biological cornea
ActiveCN114191613AExcellent optical propertiesImprove mechanical propertiesClimate change adaptationTissue regenerationAcellular matrixCell layer
The invention discloses a biological cornea prepared from swimming bladders as well as a preparation method and application of the biological cornea. Fresh swimming bladders are subjected to impurity removal, degreasing, desugaring and freeze thawing treatment, and then a decellularized solution is added to obtain a decellularized matrix of the swimming bladders; and carrying out collagenous fiber reconstruction treatment on the acellular matrix by using an alcohol-water mixed solution containing a light transmission regulator to obtain the artificial biological cornea. The swim bladder is used as a material for preparing the biological cornea, the obtained biological cornea is very close to a natural cornea in component, has excellent optical properties and excellent mechanical properties, shows excellent biocompatibility and is free of cytotoxicity through in-vitro cell culture, and cornea cells can be normally adhered and grow on the surface of the material, so that the biological cornea can be used for preparing the biological cornea. And a compact cell layer is formed and can be used as a medical material in corneal transplantation and corneal lamella repair. The carrier stent is wide in raw material source, low in production cost, convenient to store and use and capable of meeting the requirements of a large number of carrier stents of tissue engineering corneas.
Owner:SICHUAN UNIV
Cartilage acellular matrix and preparation method thereof
ActiveCN114796615AComplete structureAchieve mechanical propertiesTissue regenerationProsthesisCellular componentVirus inactivation
The invention provides a cartilage acellular matrix and a preparation method thereof. The preparation method comprises the following steps: treating clean cartilage by using an enzyme solution; a non-ionic reagent is used for removing cell components in the shallow layer; carrying out preliminary removal on deep cell components by using an ionic reagent; carrying out secondary removal on deep cell components by using a zwitterionic reagent; cleaning with purified water to obtain a decellularized cartilage material; performing degreasing treatment by using an organic solvent to obtain a degreased cartilage material; carrying out virus inactivation on the degreased cartilage material to obtain an inactivated cartilage material; and freeze-drying the inactivated cartilage material to obtain the cartilage acellular matrix. According to the preparation method of the cartilage decellularized matrix, the cartilage material does not need to be destroyed and reconstructed, the cartilage decellularized matrix is obtained under the condition that the structure of cartilage is not destroyed, and a type II collagen network of the cartilage material is well protected.
Owner:NEO MODULUS SUZHOU MEDICAL SCI TECH CO LTD
Injectable bioactive composite conductive hydrogel as well as preparation method and application thereof
ActiveCN114504683AImprove adhesionImprove biological activityPharmaceutical delivery mechanismProsthesisAcellular matrixConductive materials
The invention belongs to the technical field of tissue engineering, and particularly relates to injectable bioactive composite conductive hydrogel as well as a preparation method and application thereof, and the composite conductive hydrogel is prepared through respective physical crosslinking of acellular matrix hydrogel and PEDOT: PSS. The composite conductive hydrogel provided by the invention has extremely high electron transmission efficiency and mechanical strength, can well reduce a microenvironment for cell growth, has excellent biocompatibility, can promote tissue regeneration, has good fluidity and injectability, is not limited by shape and size when in use, can well adhere to tissues after gelatinization, and can be used for preparing the hydrogel. Extra surgical suture is not needed; the conductivity of the hydrogel can be adjusted by adjusting the adding amount of PEDOT: PSS, electrical stimulation is provided for cells by externally adding weak current, cell proliferation, migration and functionalization can be effectively promoted, and the hydrogel is expected to be prepared into a biomedical conductive material for application.
Owner:SUN YAT SEN UNIV
Preparation method of biogel and biogel prepared by preparation method
InactiveCN112546301AGuaranteed contentMild method conditionsTissue regenerationProsthesisDiseaseEngineering
The invention relates to the field of tissue engineering and biomedical materials, in particular to a preparation method of biogel and the biogel prepared by the preparation method. The method comprises the following steps: soaking an omentum by using a buffer solution containing lauryl sodium sulfate and DNA enzyme for decellularization treatment; and digesting decellularized omentum tissue by using the combined digestive enzyme liquid in combination with a digestion bottle with a rotor, and preparing the omentum decellularized matrix biogel. According to the invention, the decellularized matrix biogel is prepared by adopting the combined digestive enzyme liquid and a special digestion method thereof. Compared with the existing method, the method disclosed by the invention is milder in condition, and the obtained omentum decellularized matrix biogel can well maintain the content of various active cell factors, has good temperature sensitivity, and can be converted into the gel state from liquid state under the condition of 37 DEG C within 5-10 minutes, so that the hydrogel can be used as an injectable carrier material to be applied to cell therapy of different diseases.
Owner:北京帝康医药投资管理有限公司
A kind of ocular surface repair film and preparation method thereof
ActiveCN109498840BEasy to attachMeet the biomechanical strengthTissue regenerationProsthesisAcellular matrixIntestinal submucosa
Owner:广州聚明生物科技有限公司
A kind of artificial nerve graft and its preparation method
Owner:SUN YAT SEN UNIV +2
Preparation method and application of injectable allogeneic adipose acellular matrix microparticles
ActiveCN108478868BRich sourcesWide variety of sourcesPharmaceutical delivery mechanismTissue regenerationAcellular matrixHistiocyte
The invention discloses a preparation method and application of injectable allogeneic fat decellularized matrix microparticles. The adipose tissue obtained from liposuction is subjected to mechanical chylolysis, centrifugation to remove oil, subsequent gentle decellularization process, and centrifugation. Obtained by further degreasing; among them, the adipose tissue is derived from the human-derived fat particles discarded in the liposuction operation of traditional obese patients. The present invention adopts the method of physically crushing fat cells and degreasing methods as well as the technology of gentle decellularization, which is easy to operate and has no effect on fat loss. The matrix structure and composition are less damaged, and the obtained material is closer to the microenvironment of human natural adipose tissue, retaining the three-dimensional structure and active ingredients of the tissue, and can be injected with a small needle of 27g, which is more conducive to the proliferation and differentiation of tissue cells in the recipient area after injection , so as to promote the repair and regeneration of tissues, and play a long-term filling and rejuvenating effect. The product of the invention is suitable for facial rejuvenation and repair of soft tissue defects.
Owner:易成刚
A kind of injectable hydrogel and preparation method thereof
ActiveCN110812529BBioinducibleControllable degradation ratePharmaceutical delivery mechanismProsthesisProtein solutionCell-Extracellular Matrix
Owner:湖南美柏生物医药有限公司
Cartilage-bone integrated porous bionic scaffold and preparation method thereof
ActiveCN110180025BLow immunogenicityPromote formationTissue regenerationProsthesis3d printComputer Aided Design
The invention relates to a cartilage-bone integrated porous bionic scaffold and a preparation method thereof. The preparation method comprises: preparing cartilage decellularized matrix powder, preparing bone tissue decalcified bone matrix powder; preparing gelatin or collagen solution; preparing cartilage-containing decellularized matrix Prepare gelatin or collagen suspension containing decalcified bone matrix; prepare gelatin or collagen suspension containing cartilage decellularized matrix and decalcified bone matrix; construct cartilage-bone by computer-aided design An integrated three-dimensional digital model, which is 3D printed into a cartilage-bone integrated core grid frame; the cartilage-bone integrated grid frame is fixed in a cylindrical mold and perfused with gelatin or collagen suspension containing decalcified bone matrix , prepare the bone phase scaffold, perfuse the gelatin or collagen suspension containing cartilage decellularized matrix and decalcified bone matrix, prepare the junctional phase scaffold, and then perfuse the gelatin or collagen suspension containing cartilage decellularized matrix, prepare the cartilage phase scaffold, make Chondrogenic-osseointegrated three-dimensional cryo-stent.
Owner:SHANGHAI TISSUE ENG LIFE SCI
A kind of artificial blood vessel and preparation method thereof
ActiveCN106267369BSimple structureImprove mechanical propertiesPharmaceutical containersMedical packagingCellular componentBlood vessel
The invention discloses an artificial blood vessel and a preparation method thereof. In the present invention, the cellular components of the autologous tissue pipeline are removed by using 3-[(3-cholamidopropyl)-diethylamine]-propanesulfonic acid reagent chemical decellularization method, and then the heparin is combined in a covalent manner To the surface of the autologous acellular matrix tubing, an artificial blood vessel is obtained. The artificial blood vessel prepared by this method has no immunogenicity, short preparation period, low cost, can be prepared into different inner diameters, has good anticoagulant function, does not need complicated in vitro preparation process, high patency rate, and cells can effectively enter the vessel wall Participating in remodeling, completely superior to previous allogeneic or xenogeneic acellular matrix pipelines, has a good clinical application prospect.
Owner:海迈医疗科技(苏州)有限公司
A 3D biomimetic biological scaffold containing stem cell exosomes and its application
ActiveCN113398332BAchieve biomimetic repairSlow-release repair effect is goodAdditive manufacturing apparatusTissue regenerationBiologic scaffoldDrug biological activity
Owner:PEKING UNIV THIRD HOSPITAL
Injectable photo-crosslinking acellular matrix composite hydrogel as well as preparation method and application thereof
PendingCN114712561AUniform pore structureGood biocompatibilityPharmaceutical delivery mechanismTissue regenerationPolymer scienceTissue repair
The invention discloses injectable and photo-crosslinked acellular matrix composite hydrogel as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) mixing acellular matrix powder with an acidic pepsin solution, stirring, and removing undigested matrix particles to obtain an acellular matrix pre-gelatinizing solution; (2) carrying out precooling treatment on the decellularized matrix pregelatinizing solution, adding an alkaline solution, and adjusting the pH value to 7.0-7.4; and (3) dissolving polyethylene glycol diacrylate and a photoinitiator in a pre-cooled buffer solution, uniformly stirring with the pre-gelatinizing solution in the step (2) at 0-8 DEG C, and carrying out photo-crosslinking curing to obtain the acellular matrix composite hydrogel. The preparation method is simple and high in operability, and the prepared composite hydrogel is high in mechanical strength, long in degradation time and good in biocompatibility; the hydrogel can be used for loading growth factors, and illumination crosslinking is performed after the hydrogel is injected into a living body, so that sustainable release of the growth factors in the living body is realized, and tissue repair and regeneration are promoted.
Owner:SUZHOU UNIV
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