Acellular matrix particle product for soft tissue filling and repairing, and preparation method of acellular matrix particle product

A technology of acellular matrix and soft tissue, applied in tissue regeneration, medical science, prosthesis, etc., can solve problems such as poor resilience, hard texture, and unsmoothness, and achieve the effect of good elasticity, soft texture, and strong resilience

Pending Publication Date: 2021-12-10
江苏优创生物医学科技有限公司
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology provides improved properties with regards to creation of artificial nails on skin surfaces like those made from plasterboard (PVC). These improvements include better flexibility, durability against wear overtime, longer lifespan without losing their effectiveness due to breakage caused through repeated usage compared to traditional methods used today. Additionally, these nanoparticle products provide unique benefits including reduced irritations and odors associated therewith, making them ideal for applications where sensitive areas require protection.

Problems solved by technology

This patented technical problem addressed in this patents relates to finding an ideal filler material made up entirely of Type II Collagen (type 2) without compromising its benefiting effects during medical procedures like surgery. Current commercially available materials lacked specific strength characteristics needed for effective wound healing due to their limited mechanical stability over time.

Method used

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  • Acellular matrix particle product for soft tissue filling and repairing, and preparation method of acellular matrix particle product
  • Acellular matrix particle product for soft tissue filling and repairing, and preparation method of acellular matrix particle product
  • Acellular matrix particle product for soft tissue filling and repairing, and preparation method of acellular matrix particle product

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preparation example Construction

[0045] An embodiment of the present invention provides a method for preparing the above-mentioned acellular matrix particle product, comprising the following steps:

[0046] Step 1, low-temperature homogenization and granulation: turn on the homogenization equipment in advance to cool down the circulating water; then add the chopped acellular matrix, glacial acetic acid and purified water into the hopper, start the homogenization equipment, and open the lower discharge valve to collect the feed liquid ;Cycle 4-6 times as required; Filter the homogenate through screens of different meshes as required to obtain slurry;

[0047] Step 2, adjusting the pH: adjusting the pH of the slurry to 4.0-8.0 with 1-10% NaOH solution to obtain slurry B, that is, non-crosslinked acellular matrix particles;

[0048] Step 3, cross-linking: Insert the gas dispersion head into the bottom of the diluted slurry B, open the gas valve, adjust the gas flow rate to 0.5-2.0 liters per minute, and stir; ad...

Embodiment 1

[0062] This embodiment provides a kind of decellularized matrix particles (non-crosslinked, low crosslinked degree and high crosslinked degree), the preparation method of which comprises the following steps:

[0063] 1. Preparation of acellular matrix: take animal tissues, and prepare acellular matrix (including acellular dermal matrix, acellular peritoneal matrix, acellular pericardium matrix, acellular bladder membrane matrix, etc.).

[0064] 2. Preparation of acellular matrix particles:

[0065] 2.1 Shred: Cut the above-mentioned acellular matrix (wet state) into small pieces;

[0066] 2.2 Low temperature homogenization and granulation:

[0067] According to the size requirements of the prepared particle size, select different technical parameters, first turn on the circulating water to cool down; the shredded acellular matrix, according to 1.0-5.0% acellular matrix (wet weight), 0.1-0.3% glacial acetic acid Put the purified water into the hopper, start the homogenizatio...

Embodiment 2

[0079] This example provides an acellular matrix microparticle product for superficial dermal tissue filling and repair, including 3.5% of acellular matrix microparticles, 0.5% of suspending agent, and the balance is water for injection;

[0080] Based on the total mass of the above-mentioned acellular matrix microparticles, the acellular matrix microparticles consist of the following components in mass percentage: B1 70% and B2 30%.

[0081] The preparation method of the decellularized matrix particle product comprises the following steps:

[0082] Step 1, taking the intermediate products B1 and B2 according to the above mass percentage and mixing them uniformly to obtain the intermediate product C1;

[0083] Step 2, taking the intermediate product C1, suspending agent and water according to the above mass percentage, and mixing them uniformly to obtain the intermediate product D1;

[0084] Step 3, freeze-drying: pour the intermediate product D1 into a freeze-drying tray, an...

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Abstract

The invention provides an acellular matrix particle product for soft tissue filling and repairing, and a preparation method of the acellular matrix particle product. The acellular matrix particle product comprises the following components in percentage by mass: 2.0-10% of acellular matrix particles, 0.1-5.0% of suspending aids and the balance of water for injection, wherein the acellular matrix particles are formed by mixing one or more of non-crosslinked acellular matrix particles, low-crosslinked acellular matrix particles and high-crosslinked acellular matrix particles. The decellularized matrix particle product provided by the invention is good in elasticity, soft in texture and high in resilience force, can form decellularized matrix particle products with different degradation gradients, different degradation time and different space structures according to the preparation technologies of the decellularized matrix particle product, is suitable for filling and repairing soft tissues, including dermal superficial tissues, dermal deep tissues, subcutaneous tissues and the like, and has a good application prospect.

Description

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Claims

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Application Information

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Owner 江苏优创生物医学科技有限公司
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