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Filming support

A covered stent and film-covered technology, which is applied in the field of medical devices, can solve problems such as inability to completely cover the lesion, inflammatory response, unfavorable endothelialization and healing, etc., to effectively treat aneurysm diseases, promote tissue and blood vessel ingrowth, and achieve good results. The effect of blood compatibility

Inactive Publication Date: 2016-02-03
UNIV OF SHANGHAI FOR SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the former has poor biocompatibility and cannot be degraded by the human body, and it will cause serious inflammatory reactions when implanted in the human body; the latter has better biocompatibility, but poor mechanical properties, and the surface porosity is low, so it is difficult to Facilitate cell attachment and proliferation and delay endothelialization and healing of lesions
The structural strength of the single-layer film is poor, and the film is easily damaged during the process of crimping, releasing, and bending of the stent graft. In addition, due to the single-layer film pore structure, the film will be stretched when the stent is released. , the void structure is deformed so that the phenomenon of axial shortening is prone to occur, which eventually leads to the inability to completely cover the lesion, etc.

Method used

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Embodiment Construction

[0019] see figure 1 , figure 2 , with reference to image 3 . The stent graft of the present invention comprises a support structure 1 and a membrane 2 coated on the support structure. The covering membrane 2 is composed of at least two layers of allogeneic acellular tissue matrix membranes superimposed, and the two adjacent layers of allogenic acellular tissue matrix membranes are combined by suturing, bonding or by the covering force of the covering membrane itself. The smooth surface of each layer of matrix membrane faces the support structure and the rough surface faces outward; two adjacent layers of matrix membrane are arranged in such a way that the growth direction of collagen fiber bundles intersects to form a certain angle, and the intersection angle is 0-90 degrees but not zero. image 3 where θ is the intersection angle.

[0020] Among the at least two layers of allogeneic decellularized tissue matrix membranes, except for the innermost matrix membrane, the ot...

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Abstract

A filming support comprises a supporting structure and a film covering the supporting structure, wherein the film is composed of at least two stacked layers of allogeneic acellular tissue base film, the smooth side of each layer of the base film faces the supporting structure while the rough side faces out; the adjacent two layers of base film are arranged by crossing at a certain angle along a growth direction of a collagen bundle. In the at least two layers of the allogeneic acellular tissue base film, all base film is provided with a plurality of through holes expect for the innermost layer, and the hole diameter increases gradually from the inner layer to the outer layer. The use of the filming support is effective in reducing the formation of thrombus and endotheliosis, in enhancing film strength and reducing the axial tension of the film during the release of the filming support, and in adhering endothelial cells to promote cell differentiation to promote the ingrowth of tissues and vessels, and quickening the endothelialization of lesion areas of arterial aneurysm to give better effect in treating arterial aneurysm.

Description

technical field [0001] The invention relates to medical equipment, in particular to a covered stent. Background technique [0002] Aneurysm is caused by the partial weakening of the arterial wall due to disease, injury or congenital factors. Under the impact of blood flow, the weak point of the arterial wall protrudes outwards and gradually expands to form. Round, oval, or prismatic cystic enlargement. An aneurysm is a potentially life-threatening condition in which the aneurysm grows continuously under the impact of blood flow, compressing surrounding organs or tissues and causing symptoms. Rapid bleeding occurs when an aneurysm ruptures due to increased blood pressure or other factors. Aneurysms can occur in different parts of the body, the most common being abdominal aortic aneurysms and intracranial aneurysms. In order to avoid the high risk of surgery, endovascular interventional therapy has gradually become the main method for treating aneurysms. Endovascular interv...

Claims

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Application Information

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IPC IPC(8): A61F2/07
Inventor 胡方遒谷雪莲祈勇祥
Owner UNIV OF SHANGHAI FOR SCI & TECH
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