Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Optical tissue measurement

A tissue and collagen tissue technology, applied in tissue regeneration, measurement devices, material analysis through optical means, etc., can solve the problem of low yield

Pending Publication Date: 2020-12-04
EDWARDS LIFESCIENCES CORP
View PDF10 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, even with advanced methods, the variability of bovine pericardium results in extremely low yields of usable sheets for heart valve leaflets, averaging less than 2 sheets per sac

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Optical tissue measurement
  • Optical tissue measurement
  • Optical tissue measurement

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0055] Disclosed herein are various embodiments of devices and methods of use that rely on the optical properties and polarized light transmittance of the tissue to measure collagen bundle density and / or collagen bundle orientation in bioprosthetic tissue, such as bovine or porcine pericardium. Collagen bundle orientation and / or collagen bundle density are then used to optimize fabrication of prosthetic valve leaflets. Collagen bundles are made of collagen fibers. Collagen bundle density may be the density of collagen fibers in a bundle and / or the density of collagen bundles of a tissue region. Provided herein are exemplary embodiments of methods of visually and quantitatively measuring collagen bundle orientation and collagen bundle density of tissue samples, and using these measurements to optimize fabrication of heart valve leaflets. In particular, the systems and methods described herein measure the light transmittance of wet bovine pericardial tissue to rapidly determine...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
thicknessaaaaaaaaaa
Login to View More

Abstract

An optical method for determining collagen bundle orientation in bovine pericardium includes the use of a system having a light source which transmits light through a first polarizer, a tissue for making a prosthetic valve leaflet, and a second polarizer, where the light then illuminates a detector plate. The light that illuminates the detector plate is used to determine the orientation of collagen fiber bundles. The orientation of the collagen fiber bundles is used to determine where to cut the leaflet edges.

Description

technical field [0001] This application claims the benefit of U.S. Patent Application No. 62 / 638,581, filed March 5, 2018, the entire disclosure of which is incorporated herein by reference. Background technique [0002] The present application relates to the measurement of the orientation and density of collagen fibers of bioprosthetic tissue for implants, and more particularly to the optical measurement of the orientation and density of collagen fibers of bioprosthetic tissue for prosthetic heart valves. An optically nondestructive method for determining the orientation and density of collagen bundles in bovine pericardial tissue is provided. [0003] US Patent No. 9,498,288 (referred to herein as the "'288 patent") discloses methods of conditioning sheet-like bioprosthetic tissue and is incorporated herein by reference in its entirety. As explained in the background of the '288 patent, medical technology has long enabled open-heart surgery to replace damaged or diseased ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/50A61L31/00A61L31/14
CPCA61L27/3604A61L27/3695A61L27/507A61L31/005A61L31/14A61L27/24A61L27/3625A61L27/3629A61L27/3641A61L27/3691A61L2430/20G01N21/21G01N21/5907G05B19/4097G05B2219/36199G05B2219/45172A61F2/2415
Inventor C·S·马丁内斯
Owner EDWARDS LIFESCIENCES CORP
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com