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Breast repair patch and preparation method thereof

A technology for repairing tablets and breasts, applied in coatings, medical science, prostheses, etc., can solve problems such as shedding, affecting product appearance quality, and tissue preservation solution contamination

Inactive Publication Date: 2017-12-01
SHAANXI RUISHENG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, in the prior art, because the collagen fiber bundles on the rough surface of the biofilm tissue are easy to dissociate and fall off, especially when it is placed in the tissue preservation solution for preservation, the dissociation and floating of the collagen fiber bundles are more difficult. Seriously, it will even fall off, which seriously affects the appearance quality of the product, and will pollute the tissue preservation solution, which is not conducive to the preservation of the tissue preservation solution. At the same time, when the biofilm tissue is applied to breast repair, it is usually used The smooth surface of the biofilm tissue faces the prosthesis, and the rough surface faces the chest tissue. The physical and chemical properties of the bonding interface between the loose layer surface and the base tissue directly affect the ingrowth of the base tissue and postoperative recovery. In the prior art, there is no literature report that can further promote the adhesion, immigration and growth of breast tissue cells on the surface of the loose layer, so as to further reduce the occurrence of capsular contracture and reduce the phenomenon of breast stiffness and pain in patients

Method used

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  • Breast repair patch and preparation method thereof
  • Breast repair patch and preparation method thereof
  • Breast repair patch and preparation method thereof

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preparation example Construction

[0038] On the other hand, the embodiment of the present invention provides a kind of preparation method of breast repair sheet as mentioned above, see image 3 ,include:

[0039] Step 1) performing decellularization treatment on the mammalian membrane tissue to obtain the decellularized membrane tissue, and the membrane tissue has a double-layer structure with a dense layer and a loose layer;

[0040] Wherein, there are various methods for decellularizing the mammalian membrane tissue; for example, it can be decellularized by treatment with alkaline solution, or decellularized by enzymatic hydrolysis. Here, the decellularization method of mammalian membrane tissue is not limited, as long as the obtained membrane tissue has a double-layer structure with a dense layer and a loose layer.

[0041] Wherein, the source and acquisition method of the mammalian membrane tissue are not limited. Exemplarily, mammalian membrane tissue is obtained commercially.

[0042] Preferably, the ...

Embodiment 1

[0075] In Example 1, bovine pericardium was used as the raw material, and breast repair tablets were prepared according to the following steps.

[0076] Step 1. Tissue pretreatment: Wash the purchased bovine pericardium with pure water to remove surface impurities, dirt, fat and other connective tissues, cut off damaged tissue and irregular parts, and finally clean it with pure water.

[0077] Step 2, decellularization: the bovine pericardium cleaned in step 1 was treated with a sodium hydroxide solution with a concentration of 0.1mol / L for 60 minutes, and then washed 5 times with phosphate buffered saline for 10 minutes each time. When the pH returned to 6.0-8.0, wash with purified water 3 times for 10 minutes each time.

[0078] Step 3, degreasing: the decellularized bovine pericardium was shaken with 5 times the amount of isopropanol for 5 hours, and then washed 15 times with 15 times the amount of pure water, 10 minutes each time.

[0079] Step 4, cross-linking: put the bov...

Embodiment 2

[0084] Using porcine pericardium as raw material, the breast repair sheet was prepared according to the following method.

[0085] After tissue pretreatment, decellularization, degreasing, and cross-linking according to the method in Example 1, the pig pericardium was placed on the suction machine with the rough side facing up, and then the prepared collagen solution with a concentration of 1.0 mg / ml Evenly coated on the surface of the loose layer of porcine pericardium by negative pressure suction, the area of ​​the loose layer coated with per milliliter of collagen solution is 2.0cm 2 , the coating thickness of the collagen solution is 1.0 mm; after the coating is completed, it is placed in a vacuum drying oven at 50° C. for 0.5 h; after that, it is stored in a liquid state and packaged for sterilization.

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Abstract

The invention relates to the field of tissue engineering technology, and in particular to a breast repair patch and a preparation method thereof. Problems in the prior that collagen bundles on the surface of a loose layer become free, floating and even falling off are solved; appearance quality of the finished product (the breast repair patch) is improved and service cycle of tissue preservation liquid and preservation cycle of the finished product are prolonged; and meanwhile, the breast repair patch, when used, can facilitate adhesion and fixation of the membrane tissue loose layer, accelerate in-growth and migration of breast cells and tissues, induce generation of new tissues and greatly relieve such symptoms as hard breasts, pain and the like after an operation. According to the embodiment, the breast repair patch provided by the invention comprises a mammal membrane tissue which comprises a dense layer and the loose layer and a collagen coating which is formed on the surface of the loose layer.

Description

technical field [0001] The invention relates to the technical field of tissue engineering, in particular to a breast repair sheet and a preparation method thereof. Background technique [0002] In recent years, with the advancement of science and technology, the improvement of living standards and social civilization, the number of people undergoing breast plastic surgery is gradually increasing, and the patients come from all walks of life. [0003] Breast plastic surgery mainly includes: breast augmentation with breast prosthesis, breast sagging correction, areola plastic surgery, breast repair and breast reconstruction for patients with Ogilvy extraction; the common feature of these breast plastic surgery is that the breast prosthesis needs to be transplanted After the breast prosthesis is implanted in the patient's body, complications such as prosthesis displacement, shedding, and capsular contracture often occur due to the body's rejection of foreign bodies. [0004] A...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/34A61L27/50A61L27/58
CPCA61L27/34A61L27/3604A61L27/3629A61L27/3687A61L27/3691A61L27/50A61L27/58A61L2300/252A61L2300/412A61L2430/04A61L2430/40
Inventor 张锐利
Owner SHAANXI RUISHENG BIOTECH
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