14 results about "Capsular contracture" patented technology

The degradable breast prosthesis shaping net bag with the heterogeneous hierarchical porous structure is composed of the large-aperture structure layer and the micro-aperture structure layer, the large-aperture structure layer and the micro-aperture structure layer are formed by combining degradable fibers in a staggered mode, the degradable breast prosthesis shaping net bag and the breast prosthesis are perfectly conformal, and the mechanical property and the tissue adhesion property needed by the net bag are provided; the two cooperate to realize the integration function of the prosthesis and the tissue, and an additional suture fixing device is not needed; the overall shape of the net bag is designed to be the hemispherical upper cover and the lower end cover edge, the process of adding the net bag and a prosthesis is simplified, the operation efficiency is improved, the net bag has excellent mechanical performance and shaping capacity, the micropore structure is beneficial to adhesion and immigration of cells, rejection reaction of a body is reduced, the incidence rate of capsular contracture is remarkably reduced, and the net bag is suitable for popularization and application. The invention has the characteristics of hierarchical porous structure design, mechanical shaping capability customization and capsule contracture prevention, and provides an innovative breast prosthesis shaping and biological performance improvement scheme for breast cancer patients.

The instant invention relates to a process for the preparation of a pharmaceutical composition in sustained-release tablet form comprising from 600 milligrams to 2400 milligrams of Pirfenidone (PFD), in such a way that the drug is bioavailable during an extended period of time of 12 hours from its administration. In this way, the anti-fibrotic and anti-inflammatory action of the drug Pirfenidone is optimized. Moreover, the instant invention offers advantages and a higher therapeutic efficacy compared to other pharmaceutical forms of Pirfenidone for oral administration and its therapeutic application in the regression of chronic renal failure secondary to primary glomerulosclerosis; it shows a better activity with regard to the reduction and / or regression of deleterious effects in breast capsular contracture observed after the surgical implantation of breast implants in humans and has an important anti-TNF-α and anti-TGF-β1 action for the treatment of hepatic fibrosis.

The invention discloses a composite amnion for improving contracture after tissue repair and a preparation method of the composite amnion. The composite membrane comprises a recombinant humanized collagen nanofiber membrane located in the middle layer and human decellularized amniotic membranes attached to the two faces of the nanofiber membrane. The composite membrane is prepared by preparing a recombinant humanized collagen nanofiber membrane through an electrostatic spinning technology and pressing the recombinant humanized collagen nanofiber membrane and a human decellularized amniotic membrane. The composite membrane has excellent mechanical properties and biological activity. Animal experiment results show that the composite film can effectively inhibit capsule contracture induced by radiotherapy, and the comprehensive effect of the composite film is obviously superior to that of a single-component material in the aspects of inflammation resistance, fibrosis resistance, degradation speed delaying, capsule compliance improving and the like. The composition can be used for improving the capsule contracture of the breast prosthesis, especially the capsule contracture induced by radiotherapy.

Disclosed are a tissue expander for breast reconstruction comprising an MMP sensor and thus being capable of real-time capsular contracture monitoring and treatment, and a patient information system linked thereto. According to these, a patient or medical staff can easily check and evaluate capsular contracture, which may occur when wearing a tissue expander for breast reconstruction, and whether inflammation, a side effect, or the like is caused thereby, even outside the human body in real time. Accordingly, before or when capsular contracture occurs, effective treatment and response are possible.

Biodegradable antimicrobial films with improved surface and handling properties are provided that are solid at room temperature and substantially liquefy in situ after implantation into a mammal, such as a human patient. Methods of using the films to cover a medical device, such as a breast implant, prior to insertion into a subject are also provided. The biodegradable films may contain a drug to reduce inflammation or capsular contracture. Methods of making biodegradable films are also provided.

The invention provides a degradable breast patch used for covering an implant prosthesis, the surface of the implant prosthesis comprises a first area used for being away from pectoral muscles and a second area used for being positioned to the pectoral muscles, the breast patch is used for at least covering the first area, the part used for covering the first area is a first forming patch, and the part used for covering the second area is a second forming patch. The overall contour of the support is of a curved surface structure and comprises an inner surface contour surface and an outer surface contour surface, the internal structure of the support comprises a support body with a plurality of meshes, and any mesh is communicated with other meshes in the X-axis, Y-axis and Z-axis directions of the mesh; a plurality of submicron fibers penetrate through any mesh, and any submicron fiber extends from the outer surface contour surface to the central axis of the inner surface contour surface. Through the synergistic effect of the three-dimensional space pore structure and the penetrating mesh oriented submicron fibers, a regeneration tissue layer matched with the biomechanical property of a natural breast fat layer is finally formed on the surface of the prosthesis, and therefore continuous inhibition of capsule contracture and long-term stable fixation of the prosthesis are achieved.

Methods and products for treating capsular contractures of breast implants including (1) obtaining a platelet-rich plasma (PRP) or platelet-rich fibrin (PRF) fraction from a patient who exhibits capsular contracture of a breast implant; and (2) applying the PRP or PRF fraction to said capsular contracture, thereby relaxing the capsular contracture.

The present invention relates to a breast reconstruction tissue expander capable of real-time monitoring and treatment of capsular contracture including an MMP sensor, and a patient information system associated therewith. According to the present invention, patients or medical staff can easily check and evaluate in real-time, even from outside the human body, the presence of capsular contracture that may occur when wearing the breast reconstruction tissue expander, as well as the resulting inflammation or side effects. Consequently, effective treatment and response become possible before or when capsular contracture occurs.

Breast prostheses that are anti-biofilm implantable biomaterial devices that optionally can elute therapeutic ions such as magnesium, silver, copper and / or zinc. In certain embodiments, the devices are hydrophilic and include a capsular contracture reducing or inhibiting agent.

There is provided a soft tissue implant pocket which reduces the incidence of capsular contracture. The pocket is manufactured from a biodegradable, biocompatible polyurethane foam. The polyurethane contains biodegradable polyols and the foam has a pore size configured for cellular infiltration. The soft tissue implant pocket find use in, for example, breast augmentation and reconstruction.

Methods and products for treating capsular contractures of breast implants including (1) obtaining a platelet-rich plasma (PRP) or platelet-rich fibrin (PRF) fraction from a patient who exhibits capsular contracture of a breast implant; and (2) applying the PRP or PRF fraction to said capsular contracture, thereby relaxing the capsular contracture.

Disclosed is a degradable breast prosthesis shaping mesh (10) having a heterogeneous hierarchical porous structure, comprising a macroporous structure layer (100) and a microporous structure layer (200). The macroporous structure layer (100) and the microporous structure layer (200) are formed by alternately arranging and combining degradable fibers to conform to a breast prosthesis, thereby providing the mechanical properties and tissue adhesion properties required by the mesh (10). The macroporous structure layer and the microporous structure layer cooperate to achieve the function of integrating the prosthesis with the tissue, without the need for an additional suturing fixation device. The overall shape of the mesh (10) is designed as a hemispherical upper cover (11) and a lower end cover rim (12), thereby simplifying the assembly process with the prosthesis and improving the surgical efficiency. The mesh (10) possesses excellent mechanical properties and shaping ability. Moreover, a microporous structure facilitates the adhesion and migration of cells, reduces the rejection reaction of the body, and significantly reduces the incidence of capsular contracture.

Methods and products for treating capsular contractures of breast implants including (1) platelet-rich fibrin (PRF) fraction from a patient who exhibits capsular contracture of a breast implant; and (2) applying the PRF fraction to said capsular contracture, thereby relaxing the capsular contracture.