Bioerodible matrix for tissue involvement

a bioerodible matrix and tissue technology, applied in the field of medical implants, can solve the problems of short recovery time, few alternatives to reconstruction, and suboptimal volume retention, and achieve the effects of promoting wound healing and soft tissue reconstruction, reducing the potential for malposition or capsular contracture, and improving the effect of tissue replacemen

Inactive Publication Date: 2010-09-30
ALLERGAN INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0010]The matrices may be porous. For example, in some embodiments, the matrices have a porosity of between about 20 microns and about 350 microns. The porous matrices can be seeded with stem cells or progenitor cells prior to or during implantation in the body. When seeded with cells, the matrices may have an enhanced effectiveness in replacement thereof with the patient's own viable tissue.
[0011]There are many potential particular uses of the disclosed matrices. The disclosed matrices can promote wound healing and soft tissue reconstruction or augmentation by providing strength and covering...

Problems solved by technology

This is in part because spontaneous recovery can require a long period of time and pain can continue throughout the repair process.
Women afflicted with breast cancer, congenital defects or damage resulting from trauma have very few alternatives to reconstruc...

Method used

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Embodiment Construction

[0019]Following damage, such as that caused by a surgical incision, skin can benefit from additional support to promote wound healing. Mesh or matrix materials are generally used to provide strength to fascia and soft tissue weakened by surgery or to provide lift to soft tissue for reconstructive or cosmetic purposes including breast reconstruction or mastopexy. Two types of mesh or matrix materials are commonly used surgically for these purposes: synthetic fiber meshes and natural or modified organic or animal derived matrix materials. These currently-used materials, however, still suffer from shortcomings such as suboptimal volume retention, donor site morbidity, and in some instances, continued poor biocompatibility.

[0020]Provided are resorbable matrices to provide strength and covering for incisions and soft tissue reconstruction or augmentation. The disclosed matrices can provide immediate strength to an incision site or soft tissue reconstruction or augmentation site and also ...

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Abstract

Disclosed herein are polyurethane polymer matrices with a porosity of from about 20 microns to about 90 microns that are useful in promoting closure and protection of incision sites; supporting the lower pole position of breast implants; and providing a partial or complete covering of breast implants to provide a beneficial interface with host tissue and to reduce the potential for malpositioning or capsular contracture. The disclosed matrices can be seeded with mammalian cells.

Description

RELATED APPLICATION[0001]This application claims priority to U.S. provisional patent application 61 / 164,344, filed Mar. 27, 2009, the entire disclosure of which is incorporated herein by this reference.FIELD OF THE INVENTION[0002]The present invention generally relates to medical implants for reconstruction, augmentation and / or wound healing and more specifically relates to such implants including a polymer component and a cellular component.BACKGROUND OF THE INVENTION[0003]Often following damage such as a surgical incision, skin can benefit from additional support to promote wound healing. This is in part because spontaneous recovery can require a long period of time and pain can continue throughout the repair process.[0004]Repair of soft tissue defects also is critical following reconstructive and augmentative surgeries. For example, more than 250,000 reconstructive procedures are performed on the breast each year. Women afflicted with breast cancer, congenital defects or damage r...

Claims

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Application Information

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IPC IPC(8): A61F2/12A61K9/00A61K35/12
CPCA61L27/18A61L27/3604A61L27/3804A61L27/3834A61L27/3886A61F2/12A61L27/58A61L27/56C08L75/04C08L67/04A61P17/00A61L27/34A61L2420/06A61L2430/04
Inventor POWELL, THOMAS E.VAN EPPS, DENNIS E.
Owner ALLERGAN INC
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