Gold particles for use in therapy to prevent or reduce capsular contracture

A capsular contracture, gold particle technology, applied in the direction of electrotherapy, radiotherapy, wave energy or particle radiation treatment materials, etc., can solve the problems of expensive, recurrent capsular contracture, slightly effective and so on

Active Publication Date: 2019-12-06
SAFE IMPLANT TECH APS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The methods described above to prevent or reduce capsular contracture are often marginally effective, painful, expensive, and capsular contracture often recurs after removal procedures

Method used

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  • Gold particles for use in therapy to prevent or reduce capsular contracture
  • Gold particles for use in therapy to prevent or reduce capsular contracture

Examples

Experimental program
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Effect test

Embodiment

[0036] Experiments were carried out on ten animals using the animal model "heterotopic heart transplantation to rat neck vessels". The animal model was first described by Heron et al in 1971 [Heron I., A technique for accessory cervical heart transplantation in rabbits and rats], ActaPathol.Microbiol.Scand.[Scandina Via Acta Pathol et Microbiol], [A] 1971;79(4):366-372], after which some modifications were added by Lim et al [Lim S M, Li S Q., Accessory heart graft as surgical model in studies of transplantation immunology [assisted heart transplantation as a surgical model for transplantation immunology research], Ann Acad.Med., Singapore [Singapore Medical College Annals] 1991; 20(4):478-483]. It is an established surgical model for in vivo transplantation immunological studies and has been widely used in the last 20 years.

[0037] According to the present invention, 100 mg of the gold particles disclosed herein have a surface area greater than that of a solid sphere of co...

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PUM

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Abstract

Gold implant having a cross-section in the range of 20-100, preferably in the range of 20-40 [mu]m for use in therapy to prevent or reduce capsular contracture. Further, the invention relates to a method of producing a gold-coated implant.

Description

technical field [0001] The present invention relates to metallic gold and gold embedded or coated on the surface of implants and their use. Furthermore, the invention relates to a method for producing gold-coated implants. Background technique [0002] After a silicone implant is implanted in a human or animal, a fibrous capsule, ie, scar tissue, forms around the implant shell. Capsular contracture is known to be a condition mainly from patients with silicone implants, such as breast implants, but it can also occur with similar implants in other body parts. Capsule formation appears to occur as a result of the formation of tightly woven collagen fibers as a result of the immune system's response to foreign objects that are surgically installed into the body (e.g., breast implants, artificial pacemakers, orthopedic prosthesis). body and dental implants) responses. [0003] Capsular contracture itself is believed to occur when the collagen fiber capsule contracts, tensionin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/04A61L27/30A61L27/54
CPCA61L27/047A61L27/306A61L27/54A61L2300/104A61L2300/41A61F2/0077A61F2/0059A61F2/12A61N5/025A61N1/406A61K41/0052A61L2400/02A61F2210/0038A61F2002/0081A61F2250/0067A61L2300/602A61L2430/04A61L2300/102
Inventor 戈姆·丹舍尔
Owner SAFE IMPLANT TECH APS
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