Method for preparing three-layer core-shell structural gold magnetic nano particles

A gold magnetic nanoparticle, core-shell structure technology, applied in the direction of microsphere preparation, microcapsule preparation, inorganic material magnetism, etc.

Active Publication Date: 2012-11-07
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007]Technical problem solved: general magnetic Fe3O4 nanoparticles are prone to agglomeration, It is oxidized, which is not conducive to direct use in detection; while gold has good biological activity and low fluorescence background, it is a good coating material

Method used

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  • Method for preparing three-layer core-shell structural gold magnetic nano particles
  • Method for preparing three-layer core-shell structural gold magnetic nano particles
  • Method for preparing three-layer core-shell structural gold magnetic nano particles

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Embodiment

[0031] (2) Preparation of gold nanoparticles by reduction of THPC: Add 0.5 mL of 1 M sodium hydroxide solution to 45 mL of water, mix well and add 1 mL of THPC solution with a concentration of 0.8 μM. After the above mixture was stirred at a speed of 800 r / min for 10 min, 2 mL of chloroauric acid solution with a mass fraction of 1% was added (the volume ratio of THPC to chloroauric acid was 1:2), and the stirring was continued for 10 min before standing , to obtain THPC-reduced gold nanoparticles solution with small particle size (concentration is about 9.9 μM). image 3 A gives the assembled Fe 3 o 4 SiO 2 / The transmission electron microscope image of Au gold-magnetic composite nanoparticles, the small black dots on the outer edge are the assembled and adsorbed gold nanoparticles, which are spherical and uniform in size, with a particle size of about 3-5 nm.

[0032] (3) Assembling Fe 3 o 4 SiO 2 particles and gold nanoparticles to obtain Fe 3 o 4 SiO 2 / Au gold mag...

Embodiment 2

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Abstract

The invention discloses a method for preparing three-layer core-shell structural gold magnetic nano particles. The method comprises the following steps of: preparing amino modified core-shell structural Fe3O4 coated SiO2 particles; reducing chloroauric acid by using tetra-hydroxymethyl phosphorus chloride (THPC), wherein the obtained particles carry negative charge and are easily adsorbed to the surfaces of the amino modified Fe3O4 coated SiO2 particles; mixing and stirring suspension of the amino modified Fe3O4 coated SiO2 particles and nano gold suspension, and thus obtaining assembled gold magnetic composite particles Fe3O4 coated SiO2 / Au; and performing multi-step reduction on the surfaces of the THPC reduced nano gold particles which are adsorbed to the surfaces of the Fe3O4 coated SiO2 particles and used as crystal nuclei by using formaldehyde to obtain complete gold shells, and thus obtaining the three-layer core-shell structural gold magnetic nano particles Fe3O4 coated SiO2 coated Au. The prepared particles are uniform in particle diameter distribution and high in dispersibility, stability, magnetic responsibility and biocompatibility.

Description

[0001] Technical field: [0002] The invention belongs to the field of synthesis of nanocomposite materials, and relates to a three-layer core-shell structure gold magnetic nanoparticle Fe 3 o 4 SiO 2 Au and its preparation method, especially related to the combined use of self-assembly technology, seed growth method and colloidal reduction chemical method to prepare gold magnetic nanoparticles Fe with a three-layer core-shell structure coated with a complete gold shell 3 o 4 SiO 2 Au. [0003] Background technique: [0004] Magnetic material is a traditional material with a long history. Studies have shown that when its size enters the nanometer scale, the resulting magnetic nanomaterials will exhibit some special physical phenomena, such as: changes in coercive force, superparamagnetism, and a drop in Curie temperature. Because of these characteristics, magnetic nanoparticles, as an important part of nanomaterials, have become a research hotspot in the fields of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02H01F1/34
Inventor 何农跃江红荣曾新王婷
Owner SOUTHEAST UNIV
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