Application of microgroove forming mold in preparation of silicone rubber with microgroove pattern on surface

A technology of forming molds and micro-grooves, applied in the field of medical materials, can solve the problems of easy formation of capsule, displacement of prosthesis contracture, rupture, etc., to increase water contact angle, reduce capsule contracture, and reduce hydrophilicity Effect

Inactive Publication Date: 2015-11-04
THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the strong hydrophobicity of the surface of silicone rubber, the compatibility of tissue cells is poor, and it is easy to form a capsule, resulting in contracture and displacement of the prosthesis, and it is also easy to cause infection and rupture

Method used

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  • Application of microgroove forming mold in preparation of silicone rubber with microgroove pattern on surface
  • Application of microgroove forming mold in preparation of silicone rubber with microgroove pattern on surface
  • Application of microgroove forming mold in preparation of silicone rubber with microgroove pattern on surface

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Preparation of ordinary silicone rubber and silicone rubber with micro-groove patterns on the surface

[0026] The structure diagram of the micro groove forming die is as follows figure 1 As shown, the concave mold 1 is included, and the bottom of the concave mold 1 is provided with microscopic protrusions 2 for forming micro grooves. The microscopic protrusions 2 can be distributed in columns or rows, and of course it can be in any direction, that is, with the concave mold 1 The length and width directions of the dimples are not parallel. In this embodiment, they are preferably parallel to the width direction of the die 1, that is, they are distributed in a row, which is convenient for processing; in order to achieve a better molding effect, after experiments, the microscopic protrusions should be in a certain shape. The effect of the regular distribution of period T and H peaks will be better, among which the optimal peak value H is 4-6 μm, and the period T ...

Embodiment 2

[0030] Embodiment 2 SR and P-SR physical and chemical performance detection

[0031] Cut the material into 1cm×1cm squares, soak them in a beaker filled with 75% alcohol, place them in an ultrasonic cleaner, set parameters: power 20w, time 5min. After cleaning, place them in a constant temperature incubator at 37°C to dry, and measure the water contact angle after completely drying and cooling. The measurement environment room temperature is 28°C and the humidity is 65%. In order to measure the data accurately as soon as possible, the time used is generally within 30S. Place the test material flat on the stage of the water contact angle measuring instrument, use deionized water as the medium, randomly select 3 different parts on the SR surface, and select 3 different micro-groove areas on the P-SR, and measure 3 data point, and finally calculate the average value of the two groups of samples, the result is as follows Figure 4 As shown, the water contact angle of SR is small...

Embodiment 3

[0032] Example 3 SR and P-SR Cytocompatibility Test

[0033] Human dermal fibroblasts were used for testing, and the culture medium was DMEM culture medium containing 10% fetal bovine serum. First, the cytoskeleton structure of fibroblasts on SR and P-SR was tested by immunofluorescence method, and the specific steps were as follows:

[0034] (1) Inoculate human dermal fibroblasts in 24-well plates covered with SR and P-SR materials, inoculate 4×10 4 cells / well in 5% CO 2 , 37 ℃ constant temperature incubation for 48h;

[0035] (2) Discard the stock solution, wash with PBS 2-3 times; fix cells: 3.7% formaldehyde, 15 min; punch: 0.1% Triton X-100 / PBS, 15 min; seal: 5% goat serum, room temperature for 15 min; incubate the cytoskeleton: Actin-Tracker Green, room temperature for 1h in the dark; wash once with PBS in the dark; incubate the nuclei with Hoechst33342 for 5min;

[0036] (3) Mount the slide with 50% glycerol, and check the skeleton structure layout of the cells on th...

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Abstract

The invention discloses an application of a microgroove forming mold in preparation of silicone rubber with a microgroove pattern on the surface. The microgroove forming mold comprises a female mold, wherein microcosmic bulges used for microgroove forming and arranged in rows or lines are arranged at the bottom of the female mold, the microcosmic bulges are distributed according to the rules that the peak value ranges from 4 mu m to 6 mu m and the period ranges from 5 mu m to 7 mu m, and the depth of the female mold ranges from 0.4 mm to 0.6 mm. The silicone rubber surface is modified by the microgroove forming mold into a structure with the microgroove pattern, the water contact angle of the silicone rubber is increased, the hydrophilicity of the silicone rubber is reduced, growth behaviors of cells on the silicone rubber surface are further affected, the growth direction and space distribution of the cells on the material surface are further affected, finally, the incidence of capsular contracture is reduced, and a novel solution is provided for preparation of implant materials more applicable to clinical application.

Description

technical field [0001] The invention belongs to the field of medical materials, and in particular relates to the application of a micro-groove forming die in preparing silicone rubber with micro-groove patterns on the surface. Background technique [0002] Implantation surgery using biomaterial soft tissue substitutes is an important method for the treatment of soft tissue defects and deformities. Currently, silicone rubber (SR), expanded polytetrafluoroethylene (ePTFE), and high-density polyethylene (Medpor) are commonly used in clinical treatment. Among them, silicone rubber is the most commonly used clinically. It has the advantages of stable chemical properties, easy shaping, easy cleaning and disinfection, and good economic performance. However, due to the strong hydrophobicity of the surface of silicone rubber, the compatibility of tissue cells is poor, and it is easy to form a capsule, resulting in contracture and displacement of the prosthesis, and it is also easy t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C33/42B29C39/02B29C39/26
Inventor 雷泽源樊东力李维娟石小花
Owner THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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