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Heparan modified polyurethane/polyethersulfone blended hollow fiber membrane and preparation method thereof

A technology of polyurethane and polyethersulfone, which is applied in the field of heparan-modified polyurethane/polyethersulfone blended hollow fiber membrane and its preparation, which can solve the problems of expensive modified substances, insignificant anticoagulant effect, and complicated preparation process, etc. problem, to achieve the effect of improving blood compatibility, simple preparation method, and easy industrialization

Inactive Publication Date: 2019-02-12
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the currently prepared modified polyethersulfone hollow fiber membrane can improve the blood compatibility of the membrane material to a certain extent, the anticoagulant effect is not obvious. Defects such as low compatibility, secondary bleeding, expensive modified substances used and complicated preparation process still exist

Method used

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  • Heparan modified polyurethane/polyethersulfone blended hollow fiber membrane and preparation method thereof
  • Heparan modified polyurethane/polyethersulfone blended hollow fiber membrane and preparation method thereof
  • Heparan modified polyurethane/polyethersulfone blended hollow fiber membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Add 1% of sulfonated dihydroxypropyl chitosan-modified polyurethane, 17% of polyethersulfone, and 82% of N,N-dimethylformamide into a dissolution kettle equipped with a thermometer, agitator and reflux condensing device, Control the temperature at 70-90°C and stir for 2-20 hours; after the dissolution is complete, let it stand for 10-20 hours to complete the defoaming and obtain the membrane liquid;

[0023] Open the nitrogen valve, control the pressure of the raw material kettle to 0.08MPa, press-filter the spinning, pump the core liquid into the inner hole of the spinneret through the metering pump and extrude it, control the core liquid flow rate to 1.2mL / min, and stabilize the core liquid flow rate , start spinning; control the spinning speed of 1.5mL / min, the film liquid is pressed into the spinneret and extruded from the ring gap, after passing through the air distance of 25cm, it enters the coagulation water bath with a temperature of 30°C to cool and solidify, an...

Embodiment 2

[0025] Add 2% of sulfonated dihydroxypropyl chitosan-modified polyurethane, 18% of polyethersulfone, and 82% of N,N-dimethylformamide into a dissolution kettle equipped with a thermometer, agitator and reflux condensing device, Control the temperature at 70-90°C and stir for 2-20 hours; after the dissolution is complete, let it stand for 10-20 hours to complete the defoaming and obtain the membrane liquid;

[0026] Open the nitrogen valve, control the pressure of the raw material kettle to 0.10MPa, filter the spinning, pump the core liquid into the inner hole of the spinneret through the metering pump and extrude it, control the core liquid flow rate to 1.2mL / min, and stabilize the core liquid flow rate , start spinning; control the spinning speed of 1.3mL / min, the film liquid is pressed into the spinneret and extruded from the ring gap, after passing through the air distance of 25cm, it enters the coagulation water bath with a temperature of 30°C to cool and solidify, and then...

Embodiment 3

[0028] Add 2% of sulfonated dihydroxypropyl chitosan-modified polyurethane, 17% of polyethersulfone, and 81% of N,N-dimethylacetamide into a dissolution kettle equipped with a thermometer, agitator and reflux condensing device, Control the temperature at 70-90°C and stir for 2-20 hours; after the dissolution is complete, let it stand for 10-20 hours to complete the defoaming and obtain the membrane liquid;

[0029] Open the nitrogen valve, control the pressure of the raw material kettle to 0.06MPa, filter the spinning, pump the core liquid into the inner hole of the spinneret through the metering pump and extrude it, control the core liquid flow rate to 1.2mL / min, and stabilize the core liquid flow , start spinning; control the spinning speed of 1.5mL / min, the film liquid is pressed into the spinneret and extruded from the ring gap, after passing through the air distance of 20cm, it enters the coagulation water bath with a temperature of 30°C to cool and solidify, and then wrap...

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Abstract

The invention provides a heparan modified polyurethane / polyethersulfone blended hollow fiber membrane and a preparation method thereof. According to the heparan modified polyurethane / polyethersulfoneblended hollow fiber membrane, heparan modified polyurethane is sulfonated dihydroxypropyl chitosan modified polyurethane; the preparation method comprises the following steps: adding 1 to 10 percentof the sulfonated dihydroxypropyl chitosan modified polyurethane, 8 to 20 percent of polyethersulfone and 80 to 90 percent of a solvent into a dissolving kettle; controlling the temperature to be 70 to 90 DEG C and stirring for 2 to 20 h; after the components are completely dissolved, standing for 10 to 20 h to finish de-foaming, so as to obtain a membrane solution; then preparing the sulfonated dihydroxypropyl chitosan modified polyurethane / polyethersulfone blended hollow fiber membrane by adopting a dry-wet process spinning method. The blended hollow fiber membrane provided by the inventionhas good anticoagulation performance and physicochemical stability; a preparation technology is simple and conditions are moderate and controllable.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a heparin-like modified polyurethane / polyethersulfone blended hollow fiber membrane and a preparation method thereof. Background technique [0002] Polyethersulfone and polyurethane are blood-contact materials with great application potential. However, when unmodified polyethersulfone or polyurethane comes into contact with blood, tiny thrombus and microembolism will still occur, which limits the application of polyurethane and polyethersulfone as blood contact materials in clinical treatment. The invention aims to solve the problems of blood coagulation and thrombus when the existing polyethersulfone and polyurethane hemodialysis membranes are used, and provides a modified polyethersulfone hollow fiber membrane with good blood compatibility and a preparation method thereof. [0003] At present, the conventional method for preparing blood-compatible polyethersulfone hollow fi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/68B01D71/48B01D69/08B01D67/00
CPCB01D67/0006B01D69/08B01D71/48B01D71/68
Inventor 邱运仁王灿
Owner CENT SOUTH UNIV
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