The invention provides a preparation method of
xanthan gum copolymer nano micelles. The preparation method comprises the following steps that after degradation, dynamic
viscosity of
xanthan gum with concentration of 0.5w% is reduced to 110 mPa s, then after dried, crushed and screened, the
xanthan gum is dissolved in N, N-dimethyformamide, a N, N-dimethyformamide solution of 2-bromoisobutyryl
bromide is added, a small amount of
triethylamine is added for reaction, after obtaining brominated xanthan gum through a method of
precipitation, the brominated xanthan gum is dissolved into N, N-
dimethylformamide, diacetone-acryloamide is added, under the condition of no
oxygen, tri[2-(dimethylamino)ethyl]amine and
cuprous chloride are added to be reacted, a xanthan gum
copolymer is obtained througha method of
precipitation, and dissolved in a polarity
organic solvent to obtain a
copolymer mother solution, stirring is conducted and water is dropped into the copolymer mother solution until a
micelle solution is formed, and through
dialysis, the xanthan gum copolymer nano micelles are obtained. According to the preparation method, the prepared xanthan gum copolymer nano micelles have good morphological regularity, good
biocompatibility and stable performance as an anti-
cancer drug carrier.