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Prevention of Infection. Cancer treatment with chemotherapy, radiation therapy, surgery, and biologic therapy puts patients at risk for development of infection. Compromised immune function associated with treatment can affect morbidity and mortality.
vaccine
PCT designated stageWO2026104647A1SsRNA viruses negative-senseViral antigen ingredientsPrevention infectionInfectious Disorder
The present disclosure relates to an mRNA molecule encoding a polypeptide comprising an hMPV F protein, or an immunogenic fragment thereof, and a lumazine synthase (LuS) capable of multimerising to form a nanoparticle. Further aspects of the disclosure relate to compositions comprising the mRNA molecule and their use as a vaccine in the prevention of infectious diseases, including those caused by hMPV and RSV.
Owner:ASTRAZENECA AB