349 results about "Minimal invasiv" patented technology

The invention relates to the field of disease animal model construction, and particularly discloses a postmenopausal osteoporosis and knee osteoarthritis co-disease animal model construction method which comprises the following steps: selecting a female animal as an experimental subject; the selected female animals are injected with a GnRH agonist, meanwhile, low-calcium feed feeding and oxidative stress stimulation are conducted, and feeding is conducted for a preset time; detecting bone mineral density and bone trabecula parameters of the fed female animals, and screening qualified female animals meeting set standards; performing meniscus tearing operation on the qualified female animal, and implanting sustained release microspheres loaded with inflammatory factors at the torn part during the operation; carrying out weight-bearing training on the female animal after the operation, and continuing for a set time length; and performing health detection on the female animals at different time points. According to the method, through multi-factor collaborative induction of the PMOP, minimally invasive construction of the KOA and multi-dimensional health detection, accurate simulation of a co-disease pathological process and clinical characteristics is realized, and the authenticity and stability of the model are improved.

Described here are systems and methods for accessing Schlemm's canal and for delivering an ocular device, tool, or fluid composition therein. The ocular devices may maintain the patency of Schlemm's canal without substantially interfering with transmural fluid flow across the canal. The fluid composition may be a viscoelastic fluid that is delivered into the canal to facilitate drainage of aqueous humor by disrupting the canal and surrounding trabeculocanalicular tissues. Some systems described here may be configured to cut or tear the trabecular meshwork with the body of an elongate member located within Schlemm's canal. Other tools for disrupting these tissues and minimally invasive methods for treating medical conditions associated with elevated intraocular pressure, including glaucoma, are also described.

The invention belongs to the field of biological medicine research and development, discloses a method and a system for collecting and analyzing auditory electrophysiological data of experimental animals, and is particularly suitable for non-human primates. The method comprises the following steps: delivering a drug to a middle ear cavity through an external auditory canal, and synchronously recording auditory electrophysiological data before and after drug administration; aBR and DPOAE multi-mode detection is adopted, and the frequency range of 4 kHz to 32 kHz is covered; setting anesthesia depth and three-electrode positioning to reduce interference; optimizing the signal-to-noise ratio through noise suppression and dynamic signal superposition; an auditory threshold database is constructed, and a machine learning model is combined to judge an injured part. The system integrates a multi-modal stimulation module, a minimally invasive drug delivery device and a data analysis platform, and supports cross-species data compatibility. The accuracy of otology medicine research is remarkably improved, the surgical operation risk is avoided, and the method is suitable for gene therapy, ototoxicity screening and other scenes.

The invention relates to the technical field of system integration of minimally invasive surgery simulation training equipment, and discloses a multi-module linkage control and multi-dimensional synchronous evaluation first-aid minimally invasive simulation training system which integrates a laparoscope, anesthesia monitoring, a dummy and a control acquisition evaluation unit. The control unit realizes full-process control based on a finite-state machine: executing anesthesia parameter and instrument interlocking verification before an operation, and unlocking an operation permission after passing the verification; during an operation, the simulation person is driven in real time according to instrument operation to generate physiological changes, a critical value is triggered by misoperation to automatically switch an emergency mode, operation response is paused, and resuscitation examination is activated. The acquisition unit marks millisecond-level timestamps for videos, tracks and physiological data by using a unified clock source, and the evaluation unit generates a multi-dimensional report according to the millisecond-level timestamps. Real-time coupling of physiological parameters and operation is achieved through software and hardware closed loops, the clinical process is restored, the problem of module isolation is solved, and cooperation and evaluation accuracy is improved.

The invention relates to a flexible lockable rope-driven mechanical arm system for cardiac resection, which belongs to the technical field of minimally invasive interventional surgical instruments and comprises a flexible mechanical arm component, an end effector component, a near-end connecting seat and a locking component. The flexible mechanical arm assembly is formed by connecting a plurality of guiding discs and a plurality of locking pieces in series, the guiding discs are arranged at intervals, one locking piece is arranged every multiple guiding discs, and the guiding discs are connected with a driving rope in series through a length restraining rod. The near-end connecting base is used for being connected with a catheter sheathing canal or a mechanical arm driving base and providing an inlet for the length restraining rod and the multiple driving ropes. The end effector assembly is used for cardiac muscle resection; according to the flexible mechanical arm assembly, complex three-dimensional path planning in a narrow cardiac cavity and posture locking under a target posture can be achieved, and the positioning precision and posture stability in the myocardial resection process are improved. The end effector assembly includes a telescopic knife and a protective depth limiting structure that reduces the risk of penetrating the ventricular wall and damaging adjacent valves and conduction bundles.

The invention discloses a magnetic positioning type balloon and CT fusion navigation system for a pericardial interventional operation, and belongs to the technical field of medical surgical navigation and minimally invasive interventional instruments. The problems that in the prior art, the visual field of an endoscope is not clear due to pericardial fluid, and a preoperative CT three-dimensional model and an intraoperative magnetic positioning space are difficult to rapidly and accurately register are solved. According to the balloon type pericardium endoscope, the liquid is injected into the balloon to drain pericardium liquid, and a clear pericardium wall tissue image is collected; the position and the posture of an image sensor in the endoscope in a magnetic positioning space are determined; setting an in-vitro mark point on the body of the target person; constructing a three-dimensional model of the heart and pericardium region by collecting CT data of the target person containing the in-vitro mark points; calculating a registration transformation matrix between the two spaces; mapping the real-time position and posture of the balloon type pericardium endoscope into the three-dimensional model of the heart area; and generating and outputting a navigation image fusing the three-dimensional model of the heart area and the real-time position of the endoscope. The invention is suitable for the technical field of medical machinery.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are histotripsy and / or ultrasound transducer arrays, and associated systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. The transducer arrays provided herein can be individually tuned such that transducer arrays with different sizes, focal lengths, or transducer element sizes may work at a desired operating frequency with the same signal generator.

The invention discloses a construction method of a malignant pleural effusion prediction model, a marker combination and application, equipment and a medium. The construction method comprises the following steps: S1, obtaining characteristics of a biomarker combination; the biomarker combination is composed of three biomarkers of NGAL, CEA and CA50; s2, based on the characteristics of the biomarker combination, adopting Logistic regression analysis to respectively construct regression models corresponding to the three biomarkers, and respectively outputting parameters alpha NGAL, beta NGAL, alpha CEA, beta CEA, alpha CA50 and beta CA50; and S3, based on the output parameters in the step S2, adopting Bayesian analysis to construct a malignant pleural effusion prediction model. The method can be used for predicting the MPE probability in the pleural effusion patient, the identification and prediction accuracy is high, and compared with pleural biopsy and thoracoscopic sampling biopsy, the method has the advantages of being rapid, minimally invasive and the like.

The invention relates to a minimally invasive implantable frontal lobe brain-computer interface method and device, and the method comprises the steps: constructing an individualized brain three-dimensional model according to CT and MRI image data of a patient, presetting an optimal nasal implantation path, and carrying out the implantation of the patient through a nose under the dual guidance of a nasal endoscope and a three-dimensional navigation system, constructing a skull base passage through minimally invasive trimming of a nasal cavity / paranasal sinus structure, and performing real-time matching and overlapping on an endoscope view and the three-dimensional model by using a rigid body transformation algorithm to display the position of a surgical instrument; windowing at a preset target point, implanting the flexible electrode array into a target brain region according to a planned depth and angle through a controllable propulsion mechanism, and establishing a neural signal acquisition or stimulation interface; intelligent mode recognition is carried out on the collected neural signals, the intention or brain state of the user is decoded, and corresponding neural stimulation or feedback signals are generated. According to the method, accurate, safe and minimally invasive clinical intervention is realized through a full-chain technical scheme of individualized planning, real-time navigation, minimally invasive implantation and biological integration, and the application value of a brain-computer interface technology is remarkably improved.

The invention provides a puncture guide wire with foresight detection and penetration functions and an intelligent intervention system, and belongs to the technical field of medical minimally invasive intervention instruments. The energy conversion assembly is innovatively integrated at the head end of the puncture guide wire, and the dual functions of A-type ultrasonic foresight detection and ablation are achieved through electric or optical path driving. The system supports two implementation modes: in an electroacoustic mode, a piezoelectric micro-electro-mechanical system is used for realizing ultrasonic transceiving and ablation; in the opto-acoustic mode, ultrasonic waves are generated by utilizing the opto-acoustic effect of the optical fiber, echoes are detected by utilizing optical interference, and ablation is performed by utilizing high-energy laser or ultrasonic waves. According to the invention, blood vessel, heart and occlusion lesions are identified based on a waveform fingerprint algorithm of time domain echoes, and a high-energy mode can be dynamically switched to assist in penetrating tissues. The problems that in an existing minimally invasive interventional operation, in-vitro image guiding precision is insufficient, a traditional IVUS / ICE catheter is too large in size and high in cost, and a traditional guide wire lacks active detection and auxiliary penetrating capacity when facing complex lesions are solved.

The invention discloses a minimally invasive degradable reduction device for thoracolumbar vertebral fracture, and relates to the technical field of medical instruments. The mounting mechanism is mounted on the outer wall of the connecting rod in a sleeving manner; the pedicle screw is movably inserted into the middle of the top end of the mounting mechanism; an implantation mechanism; through cooperative work of the connecting rod, the mounting mechanism, the pedicle screw and the connecting mechanism, the whole reduction device adapts to minimally invasive approach modes such as percutaneous puncture and can be implanted into the body of a patient through a percutaneous puncture channel, a skin incision of the minimally invasive approach is small, damage to surrounding tissue is greatly reduced, and the reduction effect is good. Due to the layered design of the screw body in the pedicle screw, bone tissue ingrowth is promoted while the supporting strength is kept, and the reduction device is made of degradable materials, can be gradually degraded along with fracture healing after an operation and is metabolized and absorbed by an organism, and does not need to be taken out through a secondary operation, so that physical and mental pain of a patient is relieved; and the medical cost and the potential risk of the secondary operation are also reduced.

The present disclosure is directed to neural interface devices and methods that accesses the subarachnoid space to enable minimally invasive modulation and recording of neural structures. Exemplary embodiments may comprise an implantable pulse generator and a microelectrode catheter. In particular embodiments, the microelectrode catheter comprises one or more stimulating and recording electrodes. Exemplary embodiments may also include methods comprising performing a lumbar puncture to access the spinal subarachnoid space and advancing microcatheter through the spinal subarachnoid space.

The invention relates to the technical field of medical instruments, and discloses an intervention pump conveying device which comprises an expansion assembly, a conveying assembly and a pushing assembly, and the conveying assembly comprises a front end assembly and a rear end assembly which are detachably and fixedly connected; the expansion assembly is detachably and fixedly connected with the front end assembly, the front end assembly and the rear end assembly are connected to form an intervention channel allowing the pushing assembly to carry the intervention pump to penetrate through, and the pushing assembly is provided with a pushing channel allowing a pump line of the intervention pump to penetrate through in the axial direction. The pushing assembly can fix or loosen a pump line of the intervention pump so as to achieve pushing and releasing of the intervention pump. The invention further discloses another conveying method of the interventional pump. By constructing a split type collaborative structure, accurate pushing and stable releasing of the interventional pump are achieved, mechanical invasion and occupation to punctured blood vessels are reduced, the risk of complications such as thrombosis and bleeding is reduced, the surgical operation process is simplified, and the minimally invasive property and safety of interventional therapy are improved.

The utility model discloses a kind of visual microinvasive injectors for living body cultivation gall, belong to the technical field of pharmaceutical manufacturing.A kind of visual microinvasive injector for living body cultivation gall, including upper shell, lower shell, limit ring, sealing plate, bottom plate, sealing ring, buckles and support block, the upper shell is sleeved in the surface of lower shell and limit ring, the limit ring is sleeved in the surface of injector barrel, limit ring one end extends to the outside of upper shell, and the other end is penetrated to the inside of lower shell.The utility model is designed as integrally-formed injector, minimally invasive surgery and visualization technology are integrated, simplify surgical procedure, even non-professional technical personnel can quickly master operation method.Integrally-formed design reduces different tools needed to switch or use in cooperation in surgery, reduces surgery time, reduces operation complexity, improves surgery efficiency and safety.

Methods and devices for reducing visceral fat within the mesenteric structure of the body by cooling visceral fat within the mesentery while leaving arteries, veins, nerves and lymph nodes within the mesentery, and the mesentery membrane, undamaged, and thereafter allowing natural processes of the body to eliminate the cooled visceral fat from the body. The system comprises a pair of flat-faced cooling probes configured for insertion into the abdomen and placement on opposite sides of a section of mesentery for application of cooling power to the mesentery, at temperatures in a range which kills visceral fat cells but does not harm other tissue.

1. The name of the design product: Z-shaped probe knife. 2. The use of the design product: used for minimally invasive tenosynovectomy and nerve release surgery. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

The application discloses a deep intracranial tissue suturing and ligature instrument, which can realize suturing and ligature of deep human tissues (especially intracranial surgery). The instrument can realize suturing and ligature of deep tissues in minimally invasive treatment in clinical surgery, and can solve the problems of small operation space, difficult suturing and easy damage to surrounding tissues in traditional surgery. The operation includes two parts of suturing and steering, and the suturing operation is completed by two interchangeable needle holding levers. A universal joint device held by the rear lever can be adjusted in direction according to different requirements, and is used for coping with various complex situations.

The invention relates to a brain-computer interface system which comprises a flexible electrode array, a receiving device, a flexible connecting wire and external equipment, wherein the flexible electrode array is implanted into a meninx middle artery in a minimally invasive manner through a superficial temporal artery puncture and a vascular intervention procedure; the receiving device is embedded under the skin of a head and is provided with a signal transmitter; the external equipment is provided with a signal receiver. A flexible electrode array is implanted in an anterior branch or posterior branch of a main branch of a middle meninx artery through a superficial temporal artery intravascular minimally invasive technology, the number of electrodes and the array are arranged according to needs, and a receiving device buried in the subcutaneous part of the head is electrically connected with the flexible electrode array implanted in the middle meninx artery. Craniotomy is not needed, operative complications are avoided, minimally invasive implantation reaches the surface of the cerebral cortex, operation of a doctor is easier, the operation time is shortened, and the comfort level of a patient is improved.

The invention relates to a touch fluid neuron specific tracing imaging agent, a preparation method and application, and belongs to the technical field of nuclear medicine imaging, the tracing imaging agent is composed of a nerve tracer agent horseradish peroxidase (HRP), zirconium-89 isotope chelated by deferoxamine and a pharmaceutically acceptable carrier, the effective tracking window of the tracer agent is prolonged to 120 hours, and the effective tracking window of the tracer agent is prolonged to 120 hours. The multi-stage synaptic transfer period of the fluid touching neuron can be completely covered; the spatial resolution is improved by 5-8 times compared with that of traditional FDG-PET, and a fluid touching neuron cluster can be accurately presented; the in-vitro serum stability is excellent, the radiochemical purity is still larger than or equal to 80.5% within 120 hours, PET / MRI bimodal imaging can be adapted, drug administration is conducted through lateral ventricle minimally invasive injection, the probe is suitable for various animal models such as mice, rats and non-human primates, in-vivo dynamic tracing of sympathetic fluid neuron trans-synapses can be achieved on the premise that no tissue damage exists, and the probe has a good application prospect. And a key technical tool is provided for neural circuit analysis, neuroscience basic research and preclinical research of neurodegenerative diseases.

The present technology provides systems, devices, and methods for forming blebs to treat ocular hypertension or glaucoma. In some embodiments, a minimally invasive bleb formation device comprises an introducer sheath having a lumen extending longitudinally therethrough. The lumen has a distal end aperture insertable adjacent to a target tissue. The device further includes a wire positionable within the lumen of the introducer sheath. The wire has a first end portion, a second end portion, and an intermediate region between the first end portion and the second end portion. At least a segment of the intermediate portion is configured to extend through the distal end aperture to form a wire loop. The wire loop is moveable between a plurality of positions and is configured to disrupt and cauterize the target tissue.

The invention discloses a laparoscopic cholecystectomy superfine auxiliary instrument and relates to the technical field of medical instruments, the laparoscopic cholecystectomy superfine auxiliary instrument comprises a handle, a superfine puncture part and a head, the superfine puncture part comprises an outer sleeve and a puncture needle, the two ends of the outer sleeve are connected with the handle and the head respectively, the puncture needle is arranged in the outer sleeve, and the front end of the puncture needle is provided with a puncture tip; the handle controls the puncture needle to slide back and forth so as to control the opening and closing of the head part. According to the scheme, ultramicro-invasive puncture is achieved through the detachable head and the superfine puncture part, firstly, the superfine puncture part can conduct ultramicro-invasive opening on the abdomen of a patient through the puncture tip at the front end of the puncture needle, so that the superfine puncture part enters the abdominal cavity of the patient, and then the superfine puncture part penetrates out of the body of the patient under the guide of a converter of an umbilical laparoscope opening; the head assembly is accurately completed under in-vitro direct vision, then the head assembly is returned to the abdomen of a patient to complete an operation, and under the condition that the opening and closing distance and the clamping force of the head are proper, ultramicro-wound trepanning is completed, postoperative scars are eliminated, and the pain of the patient is relieved.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening / non-target tissues or structures.

Described herein are devices, systems, and methods for applying a tension force to various tissues. The devices may be delivered in a minimally invasive fashion and used to manipulate tissues in the nose, car, and throat. Force may be maintained by the devices for a time period that allows shaping, compression, or approximation of tissues.

This invention discloses the application of platelet-reactive protein-4 (THBS4) in the diagnosis and treatment of endometriosis. Through bioinformatics integration analysis, clinical sample validation, and in vitro and in vivo experiments, this invention confirms that THBS4 is significantly highly expressed in both ectopic lesions and peripheral blood of patients with endometriosis, and its expression level is positively correlated with disease severity. The area under the receiver operating characteristic (AUC) curve for THBS4 alone in diagnosing endometriosis is 0.930, significantly superior to cancer antigen 125 (CA125); the AUC for the combined diagnosis of THBS4 and CA125 reaches 0.968. Simultaneously, silencing the THBS4 gene effectively inhibits the proliferation, migration, and invasion of human endometrial stromal cells, and significantly reduces the volume and fibrosis area of ​​ectopic lesions in a mouse model of endometriosis. This invention provides a highly sensitive and specific new biomarker for the non-invasive or minimally invasive early diagnosis of endometriosis, and provides new targets and candidate drugs for non-hormone-dependent targeted therapy.

This document relates to the apparatus and methods used in the minimally invasive creation of arteriovenous fistula (AVF). In particular, the invention relates to the creation of an AVF using catheters and an alignment methodology that is based upon detection of asymmetric electric fields. The invention finds particular application in vascular access (VA) in the hemodialysis (HD) population.

The Extractor-Injector-Introducer Kit (EIIK) is a modular surgical system designed for minimally invasive extraction, injection, and instrument introduction to delicate tissue sites, including the brain. The kit includes a steerable radiofrequency (RF) needle (10), a sequence of concentric dilator tubes (20, 22, 24), an extractor tube (30) with a distal cutting element (32), and an injector tube (40) with a delivery lumen (42). The RF needle (10) may be coupled to an RF generator (14) for controlled ablation. The system provides safe, guided access with reduced trauma to surrounding tissue.

The application provides a guide plate for minimally invasive surgery, and relates to the technical field of skull minimally invasive surgery, and comprises a personalized customization piece, which is customized based on three-dimensional data of a patient, is suitable for being attached and worn on a target part of the patient, and is provided with a first connecting part; a standardized connecting piece, which is made of a material that is not easy to deform under high-temperature sterilization, is provided with a second connecting part for forming a detachable connection with the first connecting part, and is provided with a third connecting part; and a personalized guide piece, which is made of a material that is not easy to deform under high-temperature sterilization, is provided with a guide channel for guiding a medical implanting instrument to pass through, is provided with a fourth connecting part for forming a detachable connection with the third connecting part, and is located on an implanting path planned before surgery after the fourth connecting part is connected with the third connecting part. The manufacturing cost of the guide plate is reduced, and the good accuracy of the guide plate is ensured.

The invention provides devices, systems and methods for tissue approximation and repair at treatment sites. The devices, systems and methods of the invention will find use in a variety of therapeutic procedures, including endovascular, minimally-invasive, and open surgical procedures, and can be used in various anatomical regions, including the abdomen, thorax, cardiovascular system, heart, intestinal tract, stomach, urinary tract, bladder, lung, and other organs, vessels, and tissues. The invention is particularly useful in those procedures requiring minimally-invasive or endovascular access to remote tissue locations, where the instruments utilized must negotiate long, narrow, and tortuous pathways to the treatment site. In addition, many of the devices and systems of the invention are adapted to be reversible and removable from the patient at any point without interference with or trauma to internal tissues.

The application discloses a plugging device and relates to the technical field of medical devices. The plugging device comprises a plugging body, an elastic connecting piece and a hanging component. The plugging body is adapted to the shape of a target plugging area. One end of the elastic connecting piece is arranged on the plugging body. One end of the hanging component is connected with the other end of the elastic connecting piece, and the hanging component is adapted to be hung on the tissue of the target plugging area. The plugging device for cauliflower-shaped left atrial appendages is made of degradable materials, can be implanted into the left atrial appendages of a patient through a minimally invasive catheter intervention operation to realize plugging of the left atrial appendages, can guide the climbing of the endothelial tissue in the left atrium, and can realize complete degradation of the device in the human body after endothelialization. Finally, the plugging effect is realized by the patient's autologous tissue, the formation and shedding of thrombus embolus in the left atrial appendages are effectively prevented, and the risk of stroke is greatly reduced.

The present application relates to a kind of minimally invasive surgery executor end coordinate positioning method based on current field navigation, belong to surgical navigation positioning technical field, comprising the following steps: S1: assume an initial current source vector, obtain the distribution of rough conductivity, obtain the potential distribution at this time by positive problem calculation process, and judge whether residual is less than the set exit threshold value;S2: calculate Jacobian matrix;S3: calculate the current source vector of next time;S4: obtain the potential distribution at this time by positive problem calculation process, and compare the measured potential distribution and calculate residual;S5: after changing current electrode pair, repeat steps S1-S4 until all current electrode pairs are traversed, calculate whether total residual is less than the set exit threshold value;If not less than exit threshold value, repeat steps S2-S5;If greater than exit threshold value, stop calculation, the current source vector at this time is the current source vector approximate solution that meets the condition.