529 results about "Minimal invasiv" patented technology

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening / non-target tissues or structures.

Described here are systems and methods for accessing Schlemm's canal and for delivering an ocular device or fluid composition therein. The ocular devices may maintain the patency of Schlemm's canal without substantially interfering with transmural fluid flow across the canal. The fluid composition may be a viscoelastic fluid that is delivered into the canal to facilitate drainage of aqueous humor by disrupting the canal and surrounding trabeculocanalicular tissues. Tools for disrupting these tissues and minimally invasive methods for treating medical conditions associated with elevated intraocular pressure, including glaucoma, are also described.

The invention relates to the technical field of medical treatment, and particularly discloses a minimally invasive implantable brain-computer interface intracranial multi-mode signal monitoring system, which comprises a flexible probe, a data acquisition module, a data return module and a data analysis module, the flexible probe is embedded into the high-precision microarray electrode and the sensor to collect neural signals in real time; the data acquisition module is used for synchronously acquiring electroencephalogram signals and intracranial pressure of specific parts of the brain; the data return module manages the collected data; and the data analysis module analyzes the electroencephalogram signal and the intracranial pressure data. According to the minimally invasive implantable brain-computer interface intracranial multi-mode signal monitoring system provided by the invention, lumbar puncture enters a cerebrospinal fluid space and is sent to a target spot, so that the infection risk can be effectively reduced, the limitation on the action of a patient is reduced, and the system has the characteristics of real-time performance, directness and accuracy; the method has very important significance and value for evaluating brain injury and brain functional lesion of a patient, prognosis judgment and the like.

Described here are systems and methods for accessing Schlemm's canal and for delivering an ocular device or fluid composition therein. The ocular devices may maintain the patency of Schlemm's canal without substantially interfering with transmural fluid flow across the canal. The fluid composition may be a viscoelastic fluid that is delivered into the canal to facilitate drainage of aqueous humor by disrupting the canal and surrounding trabeculocanalicular tissues. Tools for disrupting these tissues and minimally invasive methods for treating medical conditions associated with elevated intraocular pressure, including glaucoma, are also described.

The utility model discloses a transcatheter intracardiac space occupying resection device which comprises a sheathing canal, a catheter and a guide wire. The occupied space storage mechanism is arranged in the sheath tube and is used for fixing and temporarily storing occupied spaces under the guidance of the sheath tube; and the occupying capturing and cutting mechanism is arranged in the sheath tube, connected with the occupying storage mechanism and used for capturing and cutting occupying. By puncturing the blood vessel, conveying the working guide wire and the working sheathing canal, releasing the capturing system and fixing and cutting the space-occupying lesion in the heart cavity by virtue of the negative pressure system, the minimally invasive and accurate excision of the space-occupying lesion is realized, the operation is simple and convenient, and the risk of tumor dissemination during the space-occupying excision is reduced.

Devices and methods are disclosed for treating tissue with microwave energy. Such devices and methods are able to treat cavities or surface tissue by creating one or more area or volumetric lesions. Also disclosed are flexible, low-profile devices that can be inserted non-invasively or minimally invasively near or into the target tissue as well as microwave antennas designed to generate ablation profiles that can ablate a large area or a large volume of target tissue in a single ablation. The devices include antennas wherein the field profile generated by an antenna is tailored and optimized for a particular clinical application. The antennas use unique properties of microwaves such as interaction of a microwave field with a metallic object and the use of additional shaping elements to shape the microwave field.

The present invention relates to a novel microneedle platform for minimally invasive delivery of therapeutic agents and the modulation of the neuro-immune axis in deep tissue. The present invention also adopts an innovative approach for minimally invasive and precisely controllable treatment of deep cutaneous diseases, conditions, and disorders using said electroconductive MN patch, which has the potential to benefit millions of patients worldwide.

A mechanical continuous myocardial tissue resection system, comprising: a housing, a resection cavity component, a pull lever component, an axial rotary resection knife component, a tissue locking component, a locking triggering component and an excitation component. The tissue locking component in the system is movably inserted into the resection cavity component and can lock a resection target tissue entering the internal cavity of the resection cavity component from a resection window. The locking triggering component is configured to be capable of locking the tissue locking component and can be triggered to release the locked tissue locking component. The pull lever component is configured to be capable of driving the tissue locking component and locking same with the locking triggering component. The excitation component is configured to be in linkage with the axial rotary resection knife component and the locking triggering component. The system can realize one-time puncture and continuous rotary resection in the state of a minimally invasive incision, thereby achieving precise resection of myocardial tissue.

A surgical system and method for use in implanting a neural device in a minimally invasive manner. The surgical system can include an adjustable cranial guide and various surgical tools that are dimensioned for creating a minimally invasive osteotomy and working within the subdural space.

Disclosed herein are systems, devices, and methods for the removal of objects from the body. The device may be a urethral catheter configured to aspirate kidney stones from the urinary tract through one or more aspiration ports at the distal face or along a lateral side of the catheter. The catheter may include one or more irrigation ports at the distal face or along the lateral side of the catheter for dislodging kidney stones. The device may be steerable. The spatial arrangement of the one or more irrigation ports with respect to the one or more aspiration ports may vary. The device may include an irrigation tube and / or a shield member configured to spatially confine the kidney stones adjacent the catheter. Various temporal patterns of aspiration and irrigation are disclosed for optimizing removal of kidney stones.

The invention provides a postoperative monitoring device based on an implant and a system thereof, which adopt an injectable, wireless and completely degradable ultrasonic sensor to realize real-time, continuous and non-invasive monitoring of a physiological environment (pressure, temperature and pH) around a metal internal fixture (such as a bone lamella and an intramedullary nail). The size of the sensor is 2 * 2 * 2mm < 3 >, and the sensor adopts a dual-network hydrogel matrix and a periodically arranged air column structure, is implanted into a body in a minimally invasive manner, and is naturally degraded within 4-5 weeks after an operation. The system further comprises a data processing unit and a user interface which are used for displaying monitoring data and early warning information. According to the method, the limitation of a traditional monitoring method is overcome, the monitoring accuracy and reliability are improved, the medical cost and the pain of a patient are reduced, and the method has wide clinical application prospects and social and economic values.

The invention relates to the field of disease animal model construction, and particularly discloses a postmenopausal osteoporosis and knee osteoarthritis co-disease animal model construction method which comprises the following steps: selecting a female animal as an experimental subject; the selected female animals are injected with a GnRH agonist, meanwhile, low-calcium feed feeding and oxidative stress stimulation are conducted, and feeding is conducted for a preset time; detecting bone mineral density and bone trabecula parameters of the fed female animals, and screening qualified female animals meeting set standards; performing meniscus tearing operation on the qualified female animal, and implanting sustained release microspheres loaded with inflammatory factors at the torn part during the operation; carrying out weight-bearing training on the female animal after the operation, and continuing for a set time length; and performing health detection on the female animals at different time points. According to the method, through multi-factor collaborative induction of the PMOP, minimally invasive construction of the KOA and multi-dimensional health detection, accurate simulation of a co-disease pathological process and clinical characteristics is realized, and the authenticity and stability of the model are improved.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening / non-target tissues or structures.

A system and method for the installation and operation of a cardiac assist device. Flexible guides are advanced into a prepared space using minimally invasive techniques. A heart pump construct is advanced into position in the pericardial area along the flexible guides. Once in position, the heart pump construct is activated while still engaged with the flexible guides. The flexible guides provide structural integrity to the heart pump construct needed in order for the heart pump construct to function properly. The forces supplied to the heart by the heart pump construct are affected by the presence of the flexible guides. The structure of the flexible guides, the position of the flexible guides and the structure of the heart pump construct are customized to supply the forces needed by a particular heart in order to assist the heart in pumping more efficiently.

The invention provides a negative pressure guide sheath for urinary minimally invasive intervention, which comprises a tube body, a tube seat and a negative pressure joint, and the tube body longitudinally extends from the near end to the far end; the tube base is arranged at the near end of the tube body, and the tube base and the tube body jointly define a channel penetrating through the near end and the far end. The negative pressure joint is arranged on the side wall of the tube seat and is communicated with the channel; the pressure regulating assembly is arranged at the near end of the tube seat, the pressure regulating assembly comprises an axially through gas passage, the pressure regulating assembly has a closed state and a pressure relief state, and when the pressure regulating assembly is in the closed state, after an external instrument enters the passage from the near end of the tube seat, a closed space is formed in a body cavity of a patient and the passage; and when the pressure regulating assembly is in a pressure relief state, external gas enters the channel through the gas passage.

Described here are systems and methods for accessing Schlemm's canal and for delivering an ocular device, tool, or fluid composition therein. The ocular devices may maintain the patency of Schlemm's canal without substantially interfering with transmural fluid flow across the canal. The fluid composition may be a viscoelastic fluid that is delivered into the canal to facilitate drainage of aqueous humor by disrupting the canal and surrounding trabeculocanalicular tissues. Some systems described here may be configured to cut or tear the trabecular meshwork with the body of an elongate member located within Schlemm's canal. Other tools for disrupting these tissues and minimally invasive methods for treating medical conditions associated with elevated intraocular pressure, including glaucoma, are also described.

The invention discloses a minimally invasive flexible piezoelectric-triboelectric hybrid nanometer nerve stimulation device and application thereof.The middle layer of the nerve stimulation device is a PVDF / TMCM-MnCl3 composite nanofiber membrane, Au electrodes are evaporated on the two faces of the PVDF / TMCM-MnCl3 composite nanofiber membrane, two gold wire or copper wire electrodes are connected with the Au electrodes respectively, and the two gold wire or copper wire electrodes are connected with the Au electrodes respectively. The surface of the Au electrode is subjected to primary packaging by adopting a PU waterproof film, and the surface of the PU waterproof film is subjected to secondary packaging by adopting PDMS. The nerve stimulation device is used for conventional treatment of SIRS. The vagus nerve stimulator can generate an adjustable current up to 0.85 mA under programmable ultrasonic driving, and can be directly used for VNS. The PTNG is ultrasonically driven in vitro to assist the VNS in treating lipopolysaccharide-induced SIRS rats, release of inflammatory factors such as TNF-alpha, IFN-gamma and IL-1beta can be effectively reduced, cytokine storm is relieved, and multi-organ tissue damage and dysfunction are relieved, so that the survival hope is improved.

The invention belongs to the field of biological medicine research and development, discloses a method and a system for collecting and analyzing auditory electrophysiological data of experimental animals, and is particularly suitable for non-human primates. The method comprises the following steps: delivering a drug to a middle ear cavity through an external auditory canal, and synchronously recording auditory electrophysiological data before and after drug administration; aBR and DPOAE multi-mode detection is adopted, and the frequency range of 4 kHz to 32 kHz is covered; setting anesthesia depth and three-electrode positioning to reduce interference; optimizing the signal-to-noise ratio through noise suppression and dynamic signal superposition; an auditory threshold database is constructed, and a machine learning model is combined to judge an injured part. The system integrates a multi-modal stimulation module, a minimally invasive drug delivery device and a data analysis platform, and supports cross-species data compatibility. The accuracy of otology medicine research is remarkably improved, the surgical operation risk is avoided, and the method is suitable for gene therapy, ototoxicity screening and other scenes.

The invention belongs to the technical field of biological medicines, and particularly relates to a microneedle of a drug with a short half-life period as well as a preparation method and application of the microneedle. The bipolar controllable release microneedle is provided for drugs with short half-life periods, long-acting percutaneous minimally invasive drug delivery is achieved, the convenience and comfort of a patient in drug use are greatly improved, controllable plasma concentration maintaining time can be achieved by adjusting the proportion of the first-stage release phase and the second-stage release phase, and the personalized analgesic drug delivery requirement is met. Besides, by taking an opioid analgesic administration strategy as an entry point, the precise controllable two-stage release microneedle of the biphasic matrix carried medicine is innovatively provided, a new dosage form is developed for the opioid analgesic medicine, and compared with an existing intravenous injection administration mode, the analgesic time can be prolonged by 24 times, and the analgesic effect of the medicine is greatly improved.

Apparatus, systems, and methods provide access to the renal pelvis of a kidney to treat renal nerves embedded in tissue surrounding the renal pelvis. Access to the renal pelvis may be via the urinary tract or via minimally invasive incisions through the abdomen and kidney tissue. Treatment is effected by exchanging energy, typically delivering heat or extracting heat through a wall of the renal pelvis, or by delivering active substances to ablate a thin layer of tissue lining at least a portion of the renal pelvis to disrupt renal nerves within the tissue lining of the renal pelvis.

The invention relates to the technical field of system integration of minimally invasive surgery simulation training equipment, and discloses a multi-module linkage control and multi-dimensional synchronous evaluation first-aid minimally invasive simulation training system which integrates a laparoscope, anesthesia monitoring, a dummy and a control acquisition evaluation unit. The control unit realizes full-process control based on a finite-state machine: executing anesthesia parameter and instrument interlocking verification before an operation, and unlocking an operation permission after passing the verification; during an operation, the simulation person is driven in real time according to instrument operation to generate physiological changes, a critical value is triggered by misoperation to automatically switch an emergency mode, operation response is paused, and resuscitation examination is activated. The acquisition unit marks millisecond-level timestamps for videos, tracks and physiological data by using a unified clock source, and the evaluation unit generates a multi-dimensional report according to the millisecond-level timestamps. Real-time coupling of physiological parameters and operation is achieved through software and hardware closed loops, the clinical process is restored, the problem of module isolation is solved, and cooperation and evaluation accuracy is improved.

The invention relates to a flexible lockable rope-driven mechanical arm system for cardiac resection, which belongs to the technical field of minimally invasive interventional surgical instruments and comprises a flexible mechanical arm component, an end effector component, a near-end connecting seat and a locking component. The flexible mechanical arm assembly is formed by connecting a plurality of guiding discs and a plurality of locking pieces in series, the guiding discs are arranged at intervals, one locking piece is arranged every multiple guiding discs, and the guiding discs are connected with a driving rope in series through a length restraining rod. The near-end connecting base is used for being connected with a catheter sheathing canal or a mechanical arm driving base and providing an inlet for the length restraining rod and the multiple driving ropes. The end effector assembly is used for cardiac muscle resection; according to the flexible mechanical arm assembly, complex three-dimensional path planning in a narrow cardiac cavity and posture locking under a target posture can be achieved, and the positioning precision and posture stability in the myocardial resection process are improved. The end effector assembly includes a telescopic knife and a protective depth limiting structure that reduces the risk of penetrating the ventricular wall and damaging adjacent valves and conduction bundles.

The invention discloses an intracranial hematoma minimally invasive removal orientator and a positioning method, and relates to the technical field of medical instruments. The device body comprises a fixing assembly used for stable positioning, a clamping assembly connected with the device body, a guiding device connected with the clamping assembly and a limiting assembly connected with the guiding device. After the device body, the clamping assembly and the puncture frame are positioned and clamped, a proper puncture needle is selected to penetrate into a hole of the puncture frame, the selected puncture needle is stably inserted into the skull along a set route, a strain gauge sensor detects the initial positioning position in real time, and when the error exceeds the distance of 1-2 mm, an alarm is given in time through an alarm, so that the puncture needle is prevented from being damaged. And a surgical operator is reminded of the positioning error exceeding the allowable range of the current puncture operation.

The invention discloses a magnetic positioning type balloon and CT fusion navigation system for a pericardial interventional operation, and belongs to the technical field of medical surgical navigation and minimally invasive interventional instruments. The problems that in the prior art, the visual field of an endoscope is not clear due to pericardial fluid, and a preoperative CT three-dimensional model and an intraoperative magnetic positioning space are difficult to rapidly and accurately register are solved. According to the balloon type pericardium endoscope, the liquid is injected into the balloon to drain pericardium liquid, and a clear pericardium wall tissue image is collected; the position and the posture of an image sensor in the endoscope in a magnetic positioning space are determined; setting an in-vitro mark point on the body of the target person; constructing a three-dimensional model of the heart and pericardium region by collecting CT data of the target person containing the in-vitro mark points; calculating a registration transformation matrix between the two spaces; mapping the real-time position and posture of the balloon type pericardium endoscope into the three-dimensional model of the heart area; and generating and outputting a navigation image fusing the three-dimensional model of the heart area and the real-time position of the endoscope. The invention is suitable for the technical field of medical machinery.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are histotripsy and / or ultrasound transducer arrays, and associated systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. The transducer arrays provided herein can be individually tuned such that transducer arrays with different sizes, focal lengths, or transducer element sizes may work at a desired operating frequency with the same signal generator.

The invention discloses a construction method of a malignant pleural effusion prediction model, a marker combination and application, equipment and a medium. The construction method comprises the following steps: S1, obtaining characteristics of a biomarker combination; the biomarker combination is composed of three biomarkers of NGAL, CEA and CA50; s2, based on the characteristics of the biomarker combination, adopting Logistic regression analysis to respectively construct regression models corresponding to the three biomarkers, and respectively outputting parameters alpha NGAL, beta NGAL, alpha CEA, beta CEA, alpha CA50 and beta CA50; and S3, based on the output parameters in the step S2, adopting Bayesian analysis to construct a malignant pleural effusion prediction model. The method can be used for predicting the MPE probability in the pleural effusion patient, the identification and prediction accuracy is high, and compared with pleural biopsy and thoracoscopic sampling biopsy, the method has the advantages of being rapid, minimally invasive and the like.

A minimally invasive occlusion device is disclosed. The minimally invasive occlusion device includes a first link having a first end and a second end, a second link having a first end and a second end; the first end of the second link connected to the first end of the first link by a compensating coupler. Another minimally invasive occlusion device may include a delivery frame or a shaft having an articulating cradle coupled to the shaft. A method of occluding tissue is also disclosed. The method of occluding tissue includes placing a first link of an occlusion device laterally at a base of tissue, placing a second link of an occlusion device on an opposing side of the base of tissue, substantially parallel with the first link, and securing the first link and the second link to fully occlude the base of tissue.

The present invention belongs to the field of medical devices and discloses a pulsed electric field ablation device and its use method, comprising: an ablation catheter having a hollow body with two open ends, a curved end tube and a lumen, and 2N electrodes spaced along the length of the curved end tube, where N is a positive integer and adjacent electrodes have opposite polarities. The present invention can achieve minimally invasive treatment of myocardial bridges, particularly for myocardial bridges with a coronary artery diameter of 2mm or greater. The device can be combined with an intravascular ultrasound catheter (IVUS) for treatment, providing a precise, efficient, and minimally side-effected solution to the clinical problem of myocardial bridges.

The invention relates to a minimally invasive implantable frontal lobe brain-computer interface method and device, and the method comprises the steps: constructing an individualized brain three-dimensional model according to CT and MRI image data of a patient, presetting an optimal nasal implantation path, and carrying out the implantation of the patient through a nose under the dual guidance of a nasal endoscope and a three-dimensional navigation system, constructing a skull base passage through minimally invasive trimming of a nasal cavity / paranasal sinus structure, and performing real-time matching and overlapping on an endoscope view and the three-dimensional model by using a rigid body transformation algorithm to display the position of a surgical instrument; windowing at a preset target point, implanting the flexible electrode array into a target brain region according to a planned depth and angle through a controllable propulsion mechanism, and establishing a neural signal acquisition or stimulation interface; intelligent mode recognition is carried out on the collected neural signals, the intention or brain state of the user is decoded, and corresponding neural stimulation or feedback signals are generated. According to the method, accurate, safe and minimally invasive clinical intervention is realized through a full-chain technical scheme of individualized planning, real-time navigation, minimally invasive implantation and biological integration, and the application value of a brain-computer interface technology is remarkably improved.

Described here are systems and methods for accessing Schlemm's canal and for delivering an ocular device or fluid composition therein. The ocular devices may maintain the patency of Schlemm's canal without substantially interfering with transmural fluid flow across the canal. The fluid composition may be a viscoelastic fluid that is delivered into the canal to facilitate drainage of aqueous humor by disrupting the canal and surrounding trabeculocanalicular tissues. Tools for disrupting these tissues and minimally invasive methods for treating medical conditions associated with elevated intraocular pressure, including glaucoma, are also described.