699 results about "Minimal invasiv" patented technology

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. Additional embodiments herein provide coupling systems for histotripsy including various reservoirs or ultrasound medium containers (UMC) and coupling constraints configured to interface with a reservoir or UMC during a histotripsy procedure.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening / non-target tissues or structures.

Described here are systems and methods for accessing Schlemm's canal and for delivering an ocular device or fluid composition therein. The ocular devices may maintain the patency of Schlemm's canal without substantially interfering with transmural fluid flow across the canal. The fluid composition may be a viscoelastic fluid that is delivered into the canal to facilitate drainage of aqueous humor by disrupting the canal and surrounding trabeculocanalicular tissues. Tools for disrupting these tissues and minimally invasive methods for treating medical conditions associated with elevated intraocular pressure, including glaucoma, are also described.

Described here are systems and methods for accessing Schlemm's canal and for delivering an ocular device, tool, or fluid composition therein. The ocular devices may maintain the patency of Schlemm's canal without substantially interfering with transmural fluid flow across the canal. The fluid composition may be a viscoelastic fluid that is delivered into the canal to facilitate drainage of aqueous humor by disrupting the canal and surrounding trabeculocanalicular tissues. Some systems described here may be configured to cut or tear the trabecular meshwork with the body of an elongate member located within Schlemm's canal. Other tools for disrupting these tissues and minimally invasive methods for treating medical conditions associated with elevated intraocular pressure, including glaucoma, are also described.

The invention relates to the technical field of medical treatment, and particularly discloses a minimally invasive implantable brain-computer interface intracranial multi-mode signal monitoring system, which comprises a flexible probe, a data acquisition module, a data return module and a data analysis module, the flexible probe is embedded into the high-precision microarray electrode and the sensor to collect neural signals in real time; the data acquisition module is used for synchronously acquiring electroencephalogram signals and intracranial pressure of specific parts of the brain; the data return module manages the collected data; and the data analysis module analyzes the electroencephalogram signal and the intracranial pressure data. According to the minimally invasive implantable brain-computer interface intracranial multi-mode signal monitoring system provided by the invention, lumbar puncture enters a cerebrospinal fluid space and is sent to a target spot, so that the infection risk can be effectively reduced, the limitation on the action of a patient is reduced, and the system has the characteristics of real-time performance, directness and accuracy; the method has very important significance and value for evaluating brain injury and brain functional lesion of a patient, prognosis judgment and the like.

The invention relates to the technical field of brain surgery, in particular to a construction method based on a craniocerebral tumor minimally invasive surgery risk assessment model. The method comprises the following steps: acquiring craniocerebral tumor minimally invasive surgery clinical data, including patient iconography data, surgery record data, postoperative complication data and patient basic data; performing data cleaning on the surgical clinical data, and performing standardization processing to unify a data format so as to obtain a standardized clinical data set; and extracting the size, position and shape of the tumor and the relationship between the tumor and surrounding tissues from the standardized clinical data set, and generating a tumor space structure model by using a three-dimensional reconstruction technology. According to the method, main factors influencing the surgical risk are identified through a statistical analysis method, including the contribution degree of each feature to the surgical risk and the interaction between the features, and it is ensured that the evaluation process is more objective and accurate.

The invention discloses a simulation training method and system for a minimally invasive surgery in the obstetrics and gynecology department, and relates to the technical field of virtual reality, and the method comprises the following steps: obtaining related medical data on a patient in the obstetrics and gynecology department, and carrying out the preprocessing of a medical image; the processed two-dimensional image is converted into a three-dimensional model, an operation scene is constructed, and the anatomical model of the patient in the obstetrics and gynecology department and the scene are fused; generating a plurality of operation planning schemes, calculating an operation difficulty coefficient Nd of each operation scheme, and determining an optimal operation scheme according to the size of the operation difficulty coefficient Nd; establishing an interactive interface between the doctor and the virtual operation scene, and recording various indexes of the doctor in the simulated operation process; after the simulated operation is finished, the operation is analyzed, an operation analysis report is generated, and the simulated operation is evaluated and optimized; through virtual reality minimally invasive surgery simulation, the misoperation risk in a real surgery can be reduced, so that the operation error rate in the surgery is reduced.

Described here are systems and methods for accessing Schlemm's canal and for delivering an ocular device or fluid composition therein. The ocular devices may maintain the patency of Schlemm's canal without substantially interfering with transmural fluid flow across the canal. The fluid composition may be a viscoelastic fluid that is delivered into the canal to facilitate drainage of aqueous humor by disrupting the canal and surrounding trabeculocanalicular tissues. Tools for disrupting these tissues and minimally invasive methods for treating medical conditions associated with elevated intraocular pressure, including glaucoma, are also described.

The utility model discloses a transcatheter intracardiac space occupying resection device which comprises a sheathing canal, a catheter and a guide wire. The occupied space storage mechanism is arranged in the sheath tube and is used for fixing and temporarily storing occupied spaces under the guidance of the sheath tube; and the occupying capturing and cutting mechanism is arranged in the sheath tube, connected with the occupying storage mechanism and used for capturing and cutting occupying. By puncturing the blood vessel, conveying the working guide wire and the working sheathing canal, releasing the capturing system and fixing and cutting the space-occupying lesion in the heart cavity by virtue of the negative pressure system, the minimally invasive and accurate excision of the space-occupying lesion is realized, the operation is simple and convenient, and the risk of tumor dissemination during the space-occupying excision is reduced.

Devices and methods are disclosed for treating tissue with microwave energy. Such devices and methods are able to treat cavities or surface tissue by creating one or more area or volumetric lesions. Also disclosed are flexible, low-profile devices that can be inserted non-invasively or minimally invasively near or into the target tissue as well as microwave antennas designed to generate ablation profiles that can ablate a large area or a large volume of target tissue in a single ablation. The devices include antennas wherein the field profile generated by an antenna is tailored and optimized for a particular clinical application. The antennas use unique properties of microwaves such as interaction of a microwave field with a metallic object and the use of additional shaping elements to shape the microwave field.

The present invention relates to a novel microneedle platform for minimally invasive delivery of therapeutic agents and the modulation of the neuro-immune axis in deep tissue. The present invention also adopts an innovative approach for minimally invasive and precisely controllable treatment of deep cutaneous diseases, conditions, and disorders using said electroconductive MN patch, which has the potential to benefit millions of patients worldwide.

Described here are systems and methods for accessing Schlemm's canal and for delivering an ocular device or fluid composition therein. The ocular devices may maintain the patency of Schlemm's canal without substantially interfering with transmural fluid flow across the canal. The fluid composition may be a viscoelastic fluid that is delivered into the canal to facilitate drainage of aqueous humor by disrupting the canal and surrounding trabeculocanalicular tissues. Tools for disrupting these tissues and minimally invasive methods for treating medical conditions associated with elevated intraocular pressure, including glaucoma, are also described.

The invention relates to application of HGF mRNALNP in preparation of medicine for treating emphysema, and belongs to the field of biomedicine.The HGF mRNALNP is delivered to the lung through a lipid nanoparticle carrier LNP for the first time, experiments prove that the HGF mRNALNP is high in in-vivo expression efficiency, high in lung tissue targeting performance and capable of effectively promoting repair of lung tissue structures of mice with emphysema, and the HGF mRNALNP can be used for preparing medicine for treating emphysema. The method has the characteristics of minimally invasive property and high efficiency.

A mechanical continuous myocardial tissue resection system, comprising: a housing, a resection cavity component, a pull lever component, an axial rotary resection knife component, a tissue locking component, a locking triggering component and an excitation component. The tissue locking component in the system is movably inserted into the resection cavity component and can lock a resection target tissue entering the internal cavity of the resection cavity component from a resection window. The locking triggering component is configured to be capable of locking the tissue locking component and can be triggered to release the locked tissue locking component. The pull lever component is configured to be capable of driving the tissue locking component and locking same with the locking triggering component. The excitation component is configured to be in linkage with the axial rotary resection knife component and the locking triggering component. The system can realize one-time puncture and continuous rotary resection in the state of a minimally invasive incision, thereby achieving precise resection of myocardial tissue.

A surgical system and method for use in implanting a neural device in a minimally invasive manner. The surgical system can include an adjustable cranial guide and various surgical tools that are dimensioned for creating a minimally invasive osteotomy and working within the subdural space.

Disclosed herein are systems, devices, and methods for the removal of objects from the body. The device may be a urethral catheter configured to aspirate kidney stones from the urinary tract through one or more aspiration ports at the distal face or along a lateral side of the catheter. The catheter may include one or more irrigation ports at the distal face or along the lateral side of the catheter for dislodging kidney stones. The device may be steerable. The spatial arrangement of the one or more irrigation ports with respect to the one or more aspiration ports may vary. The device may include an irrigation tube and / or a shield member configured to spatially confine the kidney stones adjacent the catheter. Various temporal patterns of aspiration and irrigation are disclosed for optimizing removal of kidney stones.

A method for performing spinal surgery may include forming an access corridor through an aspect of a facet joint of a patient between an inferior articular process of a vertebra and a superior articular process of a vertebra, wherein at least an aspect of the inferior articular process is preserved on a medial side of the access corridor and at least an aspect of the superior articular process is preserved on a lateral side of the access corridor.

The invention provides a postoperative monitoring device based on an implant and a system thereof, which adopt an injectable, wireless and completely degradable ultrasonic sensor to realize real-time, continuous and non-invasive monitoring of a physiological environment (pressure, temperature and pH) around a metal internal fixture (such as a bone lamella and an intramedullary nail). The size of the sensor is 2 * 2 * 2mm < 3 >, and the sensor adopts a dual-network hydrogel matrix and a periodically arranged air column structure, is implanted into a body in a minimally invasive manner, and is naturally degraded within 4-5 weeks after an operation. The system further comprises a data processing unit and a user interface which are used for displaying monitoring data and early warning information. According to the method, the limitation of a traditional monitoring method is overcome, the monitoring accuracy and reliability are improved, the medical cost and the pain of a patient are reduced, and the method has wide clinical application prospects and social and economic values.

The invention relates to the field of disease animal model construction, and particularly discloses a postmenopausal osteoporosis and knee osteoarthritis co-disease animal model construction method which comprises the following steps: selecting a female animal as an experimental subject; the selected female animals are injected with a GnRH agonist, meanwhile, low-calcium feed feeding and oxidative stress stimulation are conducted, and feeding is conducted for a preset time; detecting bone mineral density and bone trabecula parameters of the fed female animals, and screening qualified female animals meeting set standards; performing meniscus tearing operation on the qualified female animal, and implanting sustained release microspheres loaded with inflammatory factors at the torn part during the operation; carrying out weight-bearing training on the female animal after the operation, and continuing for a set time length; and performing health detection on the female animals at different time points. According to the method, through multi-factor collaborative induction of the PMOP, minimally invasive construction of the KOA and multi-dimensional health detection, accurate simulation of a co-disease pathological process and clinical characteristics is realized, and the authenticity and stability of the model are improved.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening / non-target tissues or structures.

The invention belongs to the field of interbody fusion cages in medical instruments, and particularly discloses an expansion type interbody fusion cage applied to minimally invasive spine surgery, which comprises a front-end extrusion block, an internal thread column is connected to the rear part of the front-end extrusion block, and the upper and lower surfaces of the front-end extrusion block are in contact with the inner sides of the front ends of an upper support plate and a lower support plate respectively; upper side edge plates are hinged to the two sides of the upper supporting plate, lower side edge plates are hinged to the two sides of the lower supporting plate, a limiting block is installed on the lower supporting plate, a connecting sliding block is installed below the upper supporting plate, and rear end extrusion blocks which are the same as the front end extrusion blocks in shape and symmetrical in position are installed on the inner sides of the rear ends of the upper supporting plate and the lower supporting plate. An adjusting hole is formed in the center of the rear end extrusion block, a hexagon socket screw is installed in the adjusting hole, a sliding hole is formed in the upper supporting plate, and an oblique nail is installed in the sliding hole. The contact area between the fusion cage and the intervertebral space can be increased, the stability of the fusion cage is improved, and the purposes of recovering the intervertebral space height and expanding the intervertebral foramen are achieved.

The invention discloses a method for promoting diabetic fracture healing by using bone marrow mesenchymal stem cell exosomes, which comprises the following steps: separating MSCs (mesenchymal stem cells) from the bone marrow of a diabetic patient, culturing and extracting the exosomes; the method comprises the following steps: extracting an exosome from a bone fracture part, performing quantitative analysis on the extracted exosome, injecting the exosome into the bone fracture part in a manner of intravenous injection, local injection or minimally invasive injection, continuously treating, promoting proliferation and differentiation of osteoblasts by miRNA or mRNA in the exosome through targeting cells, enhancing angiogenesis, and further accelerating fracture healing. According to the exosome, proliferation and differentiation of osteoblasts are promoted through miRNA or mRNA in the exosome, the synthesis capacity of bone matrixes of the osteoblasts is enhanced, so that fracture healing is accelerated, meanwhile, the exosome provides necessary blood supply for fracture healing by adjusting vascular endothelial cells and promoting angiogenesis, and the repair capacity of fracture parts is effectively improved.

A system and method for the installation and operation of a cardiac assist device. Flexible guides are advanced into a prepared space using minimally invasive techniques. A heart pump construct is advanced into position in the pericardial area along the flexible guides. Once in position, the heart pump construct is activated while still engaged with the flexible guides. The flexible guides provide structural integrity to the heart pump construct needed in order for the heart pump construct to function properly. The forces supplied to the heart by the heart pump construct are affected by the presence of the flexible guides. The structure of the flexible guides, the position of the flexible guides and the structure of the heart pump construct are customized to supply the forces needed by a particular heart in order to assist the heart in pumping more efficiently.

The invention provides a negative pressure guide sheath for urinary minimally invasive intervention, which comprises a tube body, a tube seat and a negative pressure joint, and the tube body longitudinally extends from the near end to the far end; the tube base is arranged at the near end of the tube body, and the tube base and the tube body jointly define a channel penetrating through the near end and the far end. The negative pressure joint is arranged on the side wall of the tube seat and is communicated with the channel; the pressure regulating assembly is arranged at the near end of the tube seat, the pressure regulating assembly comprises an axially through gas passage, the pressure regulating assembly has a closed state and a pressure relief state, and when the pressure regulating assembly is in the closed state, after an external instrument enters the passage from the near end of the tube seat, a closed space is formed in a body cavity of a patient and the passage; and when the pressure regulating assembly is in a pressure relief state, external gas enters the channel through the gas passage.

The utility model relates to the medical field, and discloses a pair of clamping circular forceps made of auricular cartilage and cartilage membrane composites, which comprises a rod A (1) and a rod B (2), the inner side of the top end of the rod A (1) is flatly welded with the inner side of the top end of the rod B (2), a rotating module (3) is connected to one side of the center of the lower end face of the rod B (2), and a bottom plate (5) is connected to one side of the center of the lower end face of the rod A (1). A plurality of concentric circles (4) are engraved in the center of the upper end face of the bottom plate (5); an obtuse angle of 130-140 degrees is formed between the rotating module (3) and the rod B (2), and an obtuse angle of 130-140 degrees is also formed between the bottom plate (5) and the rod A (1); when the rod A (1) and the rod B (2) are closed, the rotating module (3) is just arranged on the upper side of the bottom plate (5) in parallel; the utility model discloses meet the requirement of otologic surgery better clamping cartilage and chondromater compound, guarantee the safety and the stability of surgery, be favorable for reducing otologic graft manufacturing difficulty, be favorable for promoting the development of otologic endoscope minimally invasive surgery, save the surgery time, improve the surgery efficiency.

Described here are systems and methods for accessing Schlemm's canal and for delivering an ocular device, tool, or fluid composition therein. The ocular devices may maintain the patency of Schlemm's canal without substantially interfering with transmural fluid flow across the canal. The fluid composition may be a viscoelastic fluid that is delivered into the canal to facilitate drainage of aqueous humor by disrupting the canal and surrounding trabeculocanalicular tissues. Some systems described here may be configured to cut or tear the trabecular meshwork with the body of an elongate member located within Schlemm's canal. Other tools for disrupting these tissues and minimally invasive methods for treating medical conditions associated with elevated intraocular pressure, including glaucoma, are also described.

The invention discloses a spine minimally invasive endoscopic reduction type fusion cage, and belongs to the technical field of medical equipment.The spine minimally invasive endoscopic reduction type fusion cage comprises an upper base and a lower base, the upper base is slidably connected to the upper portion of the lower base, an upper inclined plate is arranged at the bottom of the upper base, and a lower inclined plate is arranged at the top of the lower base; the inclined face of the upper inclined plate is attached to the inclined face of the lower inclined plate, side expanding mechanisms are symmetrically and rotationally connected to the two sides of the lower base, a top expanding mechanism is slidably connected to the front side of the lower base, a threaded rod is rotationally connected to the lower base, and the upper base is in threaded connection with the threaded rod. And the threaded rod rotates to drive the upper base to slide above the lower base. The device can be implanted through a small incision in a folded state, can be expanded after entering the intervertebral space, not only can be lifted in the vertical direction and well support the intervertebral space, but also can be unfolded in a fan shape in the horizontal plane and well matched with the anatomical structure of the intervertebral space.

The invention discloses a minimally invasive flexible piezoelectric-triboelectric hybrid nanometer nerve stimulation device and application thereof.The middle layer of the nerve stimulation device is a PVDF / TMCM-MnCl3 composite nanofiber membrane, Au electrodes are evaporated on the two faces of the PVDF / TMCM-MnCl3 composite nanofiber membrane, two gold wire or copper wire electrodes are connected with the Au electrodes respectively, and the two gold wire or copper wire electrodes are connected with the Au electrodes respectively. The surface of the Au electrode is subjected to primary packaging by adopting a PU waterproof film, and the surface of the PU waterproof film is subjected to secondary packaging by adopting PDMS. The nerve stimulation device is used for conventional treatment of SIRS. The vagus nerve stimulator can generate an adjustable current up to 0.85 mA under programmable ultrasonic driving, and can be directly used for VNS. The PTNG is ultrasonically driven in vitro to assist the VNS in treating lipopolysaccharide-induced SIRS rats, release of inflammatory factors such as TNF-alpha, IFN-gamma and IL-1beta can be effectively reduced, cytokine storm is relieved, and multi-organ tissue damage and dysfunction are relieved, so that the survival hope is improved.

The invention discloses injectable and degradable composite drug-loading hydrogel as well as a preparation method and application thereof. The injectable and degradable composite drug-loading hydrogel comprises sodium alginate hydrogel, piezoelectric nanofibers and triamcinolone acetonide and / or ropivacaine, wherein the piezoelectric nanofibers and the triamcinolone acetonide and / or the ropivacaine are loaded on the sodium alginate hydrogel; the piezoelectric nanofibers are poly-L-lactic acid nanofibers. Through the synergistic effect of controllable release of the medicine and piezoelectric stimulation, the dual effects of continuous analgesia and neural restoration are achieved in the PHN treatment process, more effective treatment selection is provided for a PHN patient, complications caused by a traditional implantable electrode can be avoided, a more minimally invasive, convenient and safe treatment mode can be provided for the patient, and the treatment effect is good. And a theoretical basis is provided for future clinical practice.

The invention belongs to the field of biological medicine research and development, discloses a method and a system for collecting and analyzing auditory electrophysiological data of experimental animals, and is particularly suitable for non-human primates. The method comprises the following steps: delivering a drug to a middle ear cavity through an external auditory canal, and synchronously recording auditory electrophysiological data before and after drug administration; aBR and DPOAE multi-mode detection is adopted, and the frequency range of 4 kHz to 32 kHz is covered; setting anesthesia depth and three-electrode positioning to reduce interference; optimizing the signal-to-noise ratio through noise suppression and dynamic signal superposition; an auditory threshold database is constructed, and a machine learning model is combined to judge an injured part. The system integrates a multi-modal stimulation module, a minimally invasive drug delivery device and a data analysis platform, and supports cross-species data compatibility. The accuracy of otology medicine research is remarkably improved, the surgical operation risk is avoided, and the method is suitable for gene therapy, ototoxicity screening and other scenes.