68 results about "Minimal invasiv" patented technology

The present disclosure is directed to neural interface devices and methods that accesses the subarachnoid space to enable minimally invasive modulation and recording of neural structures. Exemplary embodiments may comprise an implantable pulse generator and a microelectrode catheter. In particular embodiments, the microelectrode catheter comprises one or more stimulating and recording electrodes. Exemplary embodiments may also include methods comprising performing a lumbar puncture to access the spinal subarachnoid space and advancing microcatheter through the spinal subarachnoid space.

The invention relates to a brain-computer interface system which comprises a flexible electrode array, a receiving device, a flexible connecting wire and external equipment, wherein the flexible electrode array is implanted into a meninx middle artery in a minimally invasive manner through a superficial temporal artery puncture and a vascular intervention procedure; the receiving device is embedded under the skin of a head and is provided with a signal transmitter; the external equipment is provided with a signal receiver. A flexible electrode array is implanted in an anterior branch or posterior branch of a main branch of a middle meninx artery through a superficial temporal artery intravascular minimally invasive technology, the number of electrodes and the array are arranged according to needs, and a receiving device buried in the subcutaneous part of the head is electrically connected with the flexible electrode array implanted in the middle meninx artery. Craniotomy is not needed, operative complications are avoided, minimally invasive implantation reaches the surface of the cerebral cortex, operation of a doctor is easier, the operation time is shortened, and the comfort level of a patient is improved.

This invention discloses the application of platelet-reactive protein-4 (THBS4) in the diagnosis and treatment of endometriosis. Through bioinformatics integration analysis, clinical sample validation, and in vitro and in vivo experiments, this invention confirms that THBS4 is significantly highly expressed in both ectopic lesions and peripheral blood of patients with endometriosis, and its expression level is positively correlated with disease severity. The area under the receiver operating characteristic (AUC) curve for THBS4 alone in diagnosing endometriosis is 0.930, significantly superior to cancer antigen 125 (CA125); the AUC for the combined diagnosis of THBS4 and CA125 reaches 0.968. Simultaneously, silencing the THBS4 gene effectively inhibits the proliferation, migration, and invasion of human endometrial stromal cells, and significantly reduces the volume and fibrosis area of ​​ectopic lesions in a mouse model of endometriosis. This invention provides a highly sensitive and specific new biomarker for the non-invasive or minimally invasive early diagnosis of endometriosis, and provides new targets and candidate drugs for non-hormone-dependent targeted therapy.

The invention provides devices, systems and methods for tissue approximation and repair at treatment sites. The devices, systems and methods of the invention will find use in a variety of therapeutic procedures, including endovascular, minimally-invasive, and open surgical procedures, and can be used in various anatomical regions, including the abdomen, thorax, cardiovascular system, heart, intestinal tract, stomach, urinary tract, bladder, lung, and other organs, vessels, and tissues. The invention is particularly useful in those procedures requiring minimally-invasive or endovascular access to remote tissue locations, where the instruments utilized must negotiate long, narrow, and tortuous pathways to the treatment site. In addition, many of the devices and systems of the invention are adapted to be reversible and removable from the patient at any point without interference with or trauma to internal tissues.

The present application relates to vitrectomy technical field, specifically disclose a kind of accurate oil exchange method and its control system in minimally invasive vitrectomy, to the problems of mutual interference, intraocular pressure fluctuation, artificial push and team cooperation caused by the same channel shared by silicon oil injection and perfluorocarbon liquid suction in prior art, the present application is physically connected by three-way component silicon oil catheter and the silicon oil perfusion control interface of vitrectomy equipment, using gas-liquid exchange air pump to provide continuous stable air pressure power source, to drive silicon oil injection with constant working pressure;At the same time, by the single manual control of surgeon suction path, according to visual observation real-time adjustment suction speed, realize the independent double-channel control and dynamic balance of silicon oil injection and perfluorocarbon liquid suction.The present application is based on the high viscosity of silicon oil and the stable voltage characteristics of air pressure power source, significantly improves the accuracy, stability and safety of operation, reduces the operation difficulty and team cooperation dependence.

The application discloses a carrier for engineering miR-124-3p The application discloses an application of an exosome hydrogel in preparation of a drug for treating traumatic brain injury, and belongs to the technical field of biological carrier drug delivery. miR-124- 3p The exosome vesicle structure can improve the stability of the miRNA in the body and the delivery efficiency of the miRNA into nerve cells, thereby enhancing the bioavailability. The engineering exosome is embedded in the QCC / OHM hydrogel system, so that the engineering exosome forms a stable delivery platform at the injury site, realizes sustained release and local enrichment of the exosome. The hydrogel material has good tissue adaptability, can enter irregular brain injury interstitial spaces through minimally invasive injection and form a scaffold structure, and provides a favorable microenvironment for nerve repair. The application can overcome the problems of poor stability of treatment molecules, short local retention time and difficulty in realizing multi-mechanism synergistic treatment, and provides a new technical scheme for treatment of traumatic brain injury.

This invention provides an ultrafine lithotripsy probe, comprising a probe base and a probe body. One end of the probe base has a mounting hole for installing the probe body. The probe body is installed in the mounting hole using an interference fit. The overall length of the ultrafine lithotripsy probe is 550mm–610mm, and the diameter of the probe body is 1.1±0.2mm. This invention can directly reach the stone lesion location through natural body cavities such as the ureter, without requiring minimally invasive perforation of the body surface, resulting in minimal trauma. Simultaneously, its structural dimensions are rationally configured, with high ultrasonic vibration transmission efficiency, excellent overall bending and fracture resistance, and is not easily broken, thus meeting the clinical needs for non-invasive lithotripsy of urinary tract stones.

The application discloses a method for treating premature ejaculation by using high-frequency muscle-bone ultrasonic guiding razor needle to release the connective tissue of the dorsal nerve of penis, and belongs to the technical field of minimally invasive treatment of male sexual dysfunction. The method can accurately distinguish the course, branch and adjacent blood vessel level of the dorsal nerve of penis and mark the safe needle insertion area through real-time imaging of high-frequency muscle-bone ultrasound. A 0.4mm razor needle is used to perform longitudinal push-cut release in the interspace of the dorsal nerve of penis under the whole-process monitoring of ultrasound, so as to release the adhesion of the loose connective tissue under the skin and the high-tension structure. Then, transverse push-cut release is performed in the coronal sulcus area, so as to reduce the local sensory afferent excitability and prolong the ejaculation latency. The application realizes visual operation in the whole process, has small trauma and is controllable and accurate, does not damage the main stem of the nerve and the blood vessel, can stably improve the symptoms of premature ejaculation and is suitable for clinical standardization and popularization.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features such as planning and implementation of an adaptive distribution of cooling periods across a treatment volume of tissue given various treatment depths and voltages. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures for tissue cooling. Other embodiments are described herein.

Minimally invasive histotripsy systems and methods are provided. In some embodiments, a minimally invasive histotripsy device is inserted into a patient. The device can be inserted endoscopically through a natural orifice of the patient, or laparoscopically through an incision in the patient's skin. The minimally invasive histotripsy device can be advanced to the target tissue and acoustically coupled to the target tissue before applying histotripsy therapy to the target tissue. In some embodiments, the minimally invasive histotripsy device includes a transducer array with a focal length of approximately 10-40 mm, a diameter of less than 35 mm, and the ability to create a peak negative focal pressure of at least 20 MPa.

This invention relates to an intraoperative nerve localization system for thoracic sympathectomy, belonging to the field of minimally invasive surgical assistance and medical information processing technology. During thoracoscopic surgery, this system identifies and analyzes candidate regions of the thoracic sympathetic nerve by acquiring intraoperative thoracoscopic images and patient physiological signals. It also verifies the sympathetic nerve properties of the target structure by combining the physiological functional responses induced by intraoperative nerve stimulation. Based on this, the system fuses and calculates the image structural information and functional response information to generate the localization reliability of the thoracic sympathetic nerve, providing the surgeon with localization references and safety prompts for thoracic sympathectomy. This system enables real-time, objective localization of the thoracic sympathetic nerve during surgery, reducing reliance on surgeon experience, lowering the risk of mis- or missed sympathectomy, and improving the safety and consistency of thoracic sympathectomy, thus possessing high clinical application value.

This invention discloses a method, apparatus, device, and medium for determining parameters of laser-induced minimally invasive ablation of bone tissue. The method includes: preparing multiple ex vivo bone tissue samples and pre-processing the bone tissue samples; dividing the pre-processed bone tissue samples into at least two groups, setting different ablation parameters for each group of bone tissue samples, and using an ultrashort pulse laser surgical device and the set ablation parameters to create the same shape feature on the corresponding group of bone tissue samples; analyzing and evaluating the shape feature on each group of bone tissue samples according to preset evaluation criteria to determine the optimal ablation parameters for the bone tissue samples. The above scheme can successfully screen the laser parameters for bone tissue ablation through in vitro experiments, and has advantages such as precision, safety, efficiency, and cleanliness, and verifies the application potential of ultrashort pulse laser surgical devices in bone tissue surgery.

A tissue removal device (20) is provided, comprising: a removal bag (30) having an opening (32) for receiving a resected tissue specimen (22) within a patient's body (24). An electrosurgical cutting wire (34) includes a cutting segment (36) and a pulling segment (40), the cutting segment (36) being detachably coupled to a wall (38) of the removal bag (30), and the pulling segment (40) being not connected to the wall (38) and extending out of the opening (32). The cutting segment (36) is wound around the central longitudinal axis (46) of the removal bag (30) at different locations along the central longitudinal axis (46). While the resected tissue specimen (22) is within the removal bag (30), the pulling segment (40) is pulled during the application of RF electrosurgical power, causing a plurality of successive longitudinal portions of the cutting segment (36) to separate from the wall (38) and cut the resected tissue specimen (22) within the removal bag (30). Other embodiments are also described.

This invention relates to a temperature-induced self-assembly cartilage repair gel, its preparation method, and its applications, belonging to the field of biomedical materials technology. The gel is prepared by dissolving recombinant type II humanized collagen and sodium hyaluronate in a mass ratio of 0.7:1 to 7:1 in 0.01M phosphate buffer and allowing it to stand at 4±2℃ for at least 3 days to complete self-assembly. Under specific ionic strength and pH conditions, the low temperature of 4±2℃ drives the recombinant type II humanized collagen and sodium hyaluronate to form an ordered interpenetrating network structure through non-covalent supramolecular interactions, endowing the gel with excellent mechanical properties and anti-enzymatic stability, while significantly promoting the proliferation, migration, and chondrogenic differentiation of bone marrow mesenchymal stem cells. A rat cartilage defect model confirms the gel's excellent in vivo repair effect. The gel can be easily extruded through a 22G-25G injection needle and is suitable for minimally invasive injection treatment of joint cartilage defects.

The application discloses an intestinal weight-reducing stent, which comprises a covered sleeve and a mesh positioning section. The covered sleeve is provided with double-layer composite covering film, the outer layer of which is a non-degradable film with multiple through holes, and the inner layer of which is a degradable film with multiple through holes, and the pore size of the through holes of the outer layer is larger than that of the inner layer. The mesh positioning section is provided with multiple types of optional auxiliary positioning structures, which can greatly reduce the risk of tissue damage during removal while ensuring stable anchoring. The intestinal weight-reducing stent realizes dynamic controllable weight-reducing effect, stable implantation and safe removal, and provides an effective minimally invasive solution for obesity treatment.

The utility model belongs to the technical field of medical apparatus and instruments, concretely relates to a minimally invasive atlas and axis internal fixation device, including base, the outside fixed connection of base has the mounting panel, the inside sliding connection of mounting panel has the bolt, the upper end contact of base has the connecting plate, the upper end fixed connection of connecting plate has the clamping plate, the inside clamping of clamping plate has the connecting rod, the lower fixed connection of connecting plate has the sliding block, the sliding block is connected with base. This minimally invasive atlas and axis internal fixation device is clamped connecting rod through a plurality of even distribution's clamping plate, can steady connecting rod from multiple directions, greatly enhanced the stability of fixed. The sliding connection of cooperation guide rod and sliding block and the adjusting effect of threaded rod, can accurate adjustment position. In operation, the doctor can more conveniently install the device to the position, ensure the fixed effect, help the patient postoperative recovery, reduce the risk because of the fixed instability brings.

The application discloses a minimally invasive surgical tissue retractor, and relates to the technical field of medical devices, which comprises a fixing ring, an adjusting ring installed at the bottom end of the fixing ring through a bearing, and a retraction mechanism installed between the bottom end of the adjusting ring and both sides thereof. The retractor is characterized by the synergetic work of an adjusting box, a guide groove, a retraction frame, a retraction plate, a first pressure sensor, a second pressure sensor and a third pressure sensor. The guide groove provides a stable sliding track for the retraction frame. The internal structure of the adjusting box drives the retraction frame and the retraction plate to realize the tissue retraction action. Meanwhile, the first pressure sensor can sense the pressure data of the contact between the retraction plate and the tissue in real time. The second pressure sensor can monitor the transmission pressure of the retraction frame. The third pressure sensor can capture the driving-related output pressure. Thus, the quantitative control of the retraction force is realized. The retraction amplitude can be accurately adjusted to fully expose the surgical field, and the hidden injuries, such as bone necrosis caused by excessive force and soft tissue tearing, can be avoided.

A shunting system comprises an endovascular shunt device, a shunt delivery catheter comprising a lumen configured for housing the endovascular shunt device, a penetrating element configured for piercing or penetrating through a wall of a vessel into an extravascular space to create an anastomosis within the wall of the vessel, and an atraumatic distal protective element configured for deflecting a critical anatomical structure (CAS) residing within the extravascular space away from the penetrating element.

1. The name of the design product: disposable surgical instruments for treating benign prostatic hyperplasia. 2. The use of the design product: medical instruments for minimally invasive treatment of benign prostatic hyperplasia by condensing steam. 3. The design features of the design product: in shape. 4. The picture or photo that best indicates the design features: perspective view.

This invention discloses an integrated nanorobot system for medical aesthetics, belonging to the field of minimally invasive and non-invasive diagnostic and treatment technology in civilian medical aesthetics. The system uses glucose-modified PCL with a glucose grafting rate of 20-25 wt% as its core substrate, adaptable to a particle size range of 100-200 nm (median 150 nm). It is a non-disassembly integrated structure with a γ-polyglutamic acid modification layer on the main surface. It embeds six functional units: precise skin detection, precise drug delivery, minimally invasive ablation, repair and regeneration, pore cleansing, and safety regulation. Each unit communicates with the safety regulation unit via carbon nanotube nano-conduction links. The safety regulation unit and the γ-polyglutamic acid modification layer work together through specific logic to construct a pH dual-redundancy control logic specific to medical aesthetic scenarios. The false trigger rate on normal skin is ≤0.05%, cytotoxicity and mucosal irritation are both grade 0, and the degradation cycle is 14±2 days. The system has a mature and reproducible manufacturing process, with a yield rate of ≥93% in 100g-level small-scale preparation. All performance indicators meet the authoritative standards of FDA / ISO medical aesthetic devices. It is specifically designed for superficial medical aesthetic repair of the human epidermis / mucous membranes, solving the technical pain points of traditional medical aesthetic devices such as single function, low precision, and many complications. It realizes a one-stop closed-loop operation of "detection-treatment-repair" and has strong clinical applicability.

This invention discloses an injectable hydrogel loaded with 4-octyl itaconic acid, its preparation method, and its applications, belonging to the field of biomedical materials technology. The injectable hydrogel is formed by enzymatic cross-linking of a hyaluronic acid-tyramine complex to create a three-dimensional network, with 4-octyl itaconic acid encapsulated within this network structure. This invention allows for precise implantation of the hydrogel into the intervertebral disc lesion via minimally invasive injection, achieving local high-concentration drug accumulation. The three-dimensional network of the hydrogel serves as a drug reservoir, enabling continuous and controllable release of 4-OI, prolonging the drug's duration of action and achieving long-term therapeutic effects. Simultaneously, the loaded 4-OI specifically activates the Nrf2 / GPX4 antioxidant pathway in nucleus pulposus cells, mechanistically antagonizing ferroptosis and matrix degradation, thus achieving a dual function of mechanical support and biological therapy. It exhibits good biocompatibility and solves the problems of difficult targeted drug delivery, short-lived efficacy, and lack of disease-modifying effects in existing treatments for intervertebral disc degeneration.

The invention relates to a device comprising an implant, in particular in the form of a stent, which can be expanded into an implanted state, wherein the device also has an active-substance-releasing system, which is or can be connected at least partially or in regions to the implant and can be introduced into the body of the patient separately or together with the implant in a compressed insertion state, in particular minimally invasively, and can be expanded at the implantation site into an implanted state. According to the invention, it is provided in particular that the active-substance-releasing system is designed in such a way that it is not subjected to any or at least substantially not to any non-linear elastic and / or plastic deformation during the expansion of the implant at the implantation site and / or during the expansion of the active-substance-releasing system at the implantation site and during the associated change in shape of the implant and / or of the active-substance-releasing system.

The application discloses a kind of orthopedics minimally invasive universal reset device, it is related to medical instrument technical field, including fixed rod, first fixed component, moving assembly and second fixed component;Fixed rod is equipped with rack and horizontal groove;First fixed component realizes multi-angle fixed kirschner wire by first connecting rod and first mounting rod;Moving assembly realizes quick sliding positioning by cooperating with gear rack and pinion of shift plate, realizes accurate traction reset and self-locking by worm and bevel gear meshing transmission of runner;Second fixed component realizes universal angle adjustment by ball joint, and vacuum adsorption and sealing rubber ring extrusion are carried out by the threaded transmission drive piston of gear ring and moving plate, realize the double locking of ball joint.The application realizes the quick positioning of kirschner wire in orthopedics minimally invasive surgery, universal angle adjustment and stable traction reset, solves the problems of slow adjustment speed, angle limitation and complicated operation of existing orthopedic reset device, significantly improves the efficiency and reset accuracy of minimally invasive surgery.

1. Name of the product in this design: Expandable bone reamer. 2. Purpose of this design: In minimally invasive spinal surgery, it is used to expand and reshape bones to increase the surgical operating space. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key features: the front view.

The invention provides an instrument (1) for minimally invasive surgery, preferably for laparoscopy, having a shank tube (11), a joint piece (12) which is articulated to the shank tube (11) at a distal end of the shank tube (11) such that the joint piece (12) can be pivoted relative to the shank tube (11) about an axis of rotation (A), and an inner piece (13) which is partially inserted into the shank tube (11) and can be moved axially within the shank tube (11) via a proximal actuator mechanism (15, 16), wherein the inner piece (13) is coupled on its distal end (133) to the joint piece (12) in such a way that an axial movement of the inner piece (13) causes the joint piece (12) to pivot about the axis of rotation (A).

Disclosed herein are various embodiments directed to a device for minimally invasive medical treatment. The device being a hollow tube with a first end, a second end, and one or more anchors configured to extend outward from the exterior of the hollow tube. The hollow tube having a plurality of cutouts on the exterior, wherein the cutouts allow the hollow tube to be flexible. Additionally, the hollow tube may have at least one snap mechanism configured to connect the first end and the second end together.

The application discloses a device for removing loose disc nucleus pulposus fragments under a spinal minimally invasive surgery endoscope and belongs to the technical field of spinal minimally invasive surgery instruments. The device comprises a handle, a first fixing frame is fixedly connected to the inside center of the handle, a suction pipe assembly is rotatably connected to the inner wall of the first fixing frame, a removing mechanism is installed at the inside center of the suction pipe assembly, and a driving mechanism is installed in the handle. The removing mechanism can not only suck out the disc nucleus pulposus fragments, but also cut the nucleus pulposus fragments with flocculent tissue involvement through a cutting cylinder, so that the nucleus pulposus fragments are cut off from the disc, and finally, the nucleus pulposus fragments are also sucked out. The device can remove multiple nucleus pulposus fragments at one time, and the surgeon does not need to pick up the fragments one by one, so that the surgery efficiency is improved. Meanwhile, the device can also suck out the nucleus pulposus fragments in the corners of the disc, so that the surgery effect is improved.

This application relates to an endovascular suture device for minimally invasive surgery of the upper respiratory tract and neck, belonging to the technical field of medical suture devices. It includes an operating handle, a puncture rod rotatably mounted on the operating handle, an anastomosis head rotatably mounted on the end of the puncture rod, and a suture assembly mounted on the anastomosis head. The anastomosis head has a suture groove on its end side, the opening width of which is greater than the width of the wound to be sutured. The anastomosis head's end side and the opposite side walls of the suture groove are located on opposite sides of the wound to be sutured. The rotation axis of the puncture rod is aligned with its length direction, and the rotation axis of the anastomosis head is perpendicular to the rotation axis of the puncture rod. This application facilitates endovascular suture of the upper respiratory tract (nasopharynx, trachea, etc.) and neck organs (thyroid, parotid gland, etc.), achieving the effects of endovascular repair and hemostasis.

The application belongs to the technical field of biomedical experimental animal model construction, and provides a rat severe spinal cord injury immediate decompression model construction method. The method establishes a standardized surgical procedure, including minimally invasive exposure through the paraspinal muscle gap, precise dura mater incision, warm saline low-pressure lavage debridement, and strict dura mater suture repair. The method realizes immediate and effective reduction of intrathecal pressure, removal of harmful substances in the injury area, and stabilization of the local microenvironment after severe spinal cord injury. The application solves the problems of instability, poor repeatability, and difficulty in simulating the clinical decompression effect caused by the non-standard dura mater incision, uncontrollable lavage, and high risk of secondary injury in the prior art. The model constructed by the method is highly standardized and has strong repeatability, and is suitable for in-depth study of the neuroprotective mechanism of dura mater incision decompression treatment for spinal cord injury.