40results about How to "Promote thrombosis" patented technology

A multi-layer occluder for treating a target site within the body is provided. The occluder may include first and second layers. For example, the first layer may include braided strands of metallic material, and the second layer may include braided strands of polymeric material. At least one of the first or second layers may be configured to facilitate thrombosis.

Embodiments of the present invention provide medical devices for treating a target site within the body and associated methods for fabricating and delivering medical devices. According to one embodiment, a medical device includes a tubular structure having proximal and distal ends and a side wall extending therebetween. At least a portion of the side wall can have a corrugated surface. The side wall further includes at least one layer of a metallic fabric configured to be compressed and heat set to define the corrugated surface. The tubular structure may comprise an expanded shape, and may be configured to be constrained to a smaller diameter than the expanded shape for delivery within a catheter to a target site and to assume the expanded shape upon release from the catheter.

Embodiments of the present invention provide medical devices and methods for treating a target site within the body. For example, a medical device includes a multi-layered structure comprising an inner layer disposed within an outer layer, wherein each of the inner and outer layers has respective inner and outer surfaces. The multi-layered structure further comprises at least offset located between the inner and outer layers or formed in the inner and/or outer layers to define at least one gap therebetween such that a majority of the outer surface of the inner layer is spaced apart from the inner surface of the outer layer. The multi-layered structure is configured to be deployed within a lumen such that at least a portion of the outer layer is configured to engage the lumen and the at least one gap is configured to promote thrombosis between the inner and outer layers.

Embodiments of an endovascular device and of methods for treating an aneurysm therewith are described. In certain embodiments, an endovascular device includes a distal assembly coupled to a flow reducing member. In some embodiments, the distal assembly is composed of multiple engagement members that, when deployed within an aneurysm, engage an inner surface of the aneurysm. In certain embodiments, the engagements members are substantially parallel to a central axis of the distal assembly in a first position and shift away from the central axis to a second position, and the distal ends of some engagement members are substantially curled when in the second position. In certain embodiments, the flow-reducing member reduces blood flow from a blood vessel into the aneurysm. In certain embodiments the flow reducing member includes a membrane, which can include a porous section.

The remotely imagable pellet system described has a plurality of pellets disposed within a delivery tube or cannula that are formed at least in part of a polysaccharide such as starch and at least one radiographically detectable bioabsorbable pellet which preferably has a radiopaque element. The radiographically detectable bioabsorbable pellet has at least one and preferably two pellets proximal and distal thereto which are formed of polysaccharide.

PCT No. PCT/JP96/02596 Sec. 371 Date Mar. 12, 1998 Sec. 102(e) Date Mar. 12, 1998 PCT Filed Sep. 12, 1996 PCT Pub. No. WO97/10224 PCT Pub. Date Mar. 20, 1997This invention provides new benzoxazepine compounds represented by the formula: [wherein R stands for a lower alkyl group optionally substituted with a hydroxyl group, X stands for an optionally substituted carbamoyl group or an optionally substituted heterocyclic group having a deprotonatable hydrogen atom, R1 stands for a lower alkyl group and W stands for a halogen atom] having activities of lowering chlesterol-level and lowering trigluceride-level, and being useful for prophylaxis and therapy of hyperlipidemia.

The present invention relates to covered endoprosthetic devices. Covered endoprosthetic devices comprise an endoprosthesis and a sheath. The sheath comprises a central portion and outer portions, wherein the central portion preferentially restricts or causes a restriction of blood flow. Blood flow can be reduced by the central portion of the sheath by varying the permeability of the sheath or by having projections on the sheath that slow blood flow. Permeability may be provided by perforations or holes in the material of the sheath or by varying the polymer structure that makes up the sheath itself. The outer portions of the sheath do not substantially reduce blood flow. Methods of using sheath-covered endoprosthetic devices of the invention to treat aneurysms, especially aneurysms in proximity to small perforator vessels or arteries, are also encompassed.

It is disclosed herein that protein C functions as a hemostatic agent. Thus, provided is a method of preventing, treating or ameliorating abnormal bleeding in a subject, comprising administering to the subject a protein C polypeptide or polynucleotide. Abnormal bleeding can result from a bleeding disorder, such as hemophilia or a platelet disorder, or from a bleeding episode, such as from a traumatic injury.

A stretch-resistant occlusive device having an elongated, substantially cylindrical porous elastomeric structure and at least one of an elongated stretch-resistant tube and at least one stretch-resistant filament. The porous structure lies within an elongated outer embolic structure such as a helically wound embolic coil.

The invention relates to the treatment and prevention of atherosclerosis and cardiovascular diseases associated with atherosclerosis. The invention further relates to methods of diagnosing atherosclerosis and cardiovascular diseases associated with atherosclerosis. In certain embodiments, the invention provides biological systems and methods for delivering a therapeutic agent or an imaging agent to atherosclerotic lesions such as vulnerable plaques.

The invention discloses an electronic detaching and etching covered stent for the treatment of intracranial aneurysm. The electronic detaching and etching covered stent comprises a stent main body with a cylindrical net structure, wherein the surface of the stent middle segment of the stent main body is packaged with a plastic cover, and one end of the stent main body is also connected with a push device; the push device comprises a guide wire and a delivery guide tube arranged on the guide wire in a sleeving manner, and the front end of the guide wire is welded at one end of the stent main body with thermal fusing metal. The electronic detaching and etching covered stent can enable intracranial aneurysm haemodynamics to change, promote thrombogenesis and thrombus organization in aneurysm, achieve the purpose of anatomically reconstructing parent artery, and keep the parent artery and branches unobstructed. The electronic detaching and etching covered stent has the advantages of being simple in structure, easy to operate, precise in positioning, high in safety and total obliteration rate and low in recurrence rate and can be recycled, so that the surgery cost is reduced.

Vaso-occlusive devices are provided that have a polymer foam disposed about them. The polymer is treated with a plasma to facilitate thrombogenicity. A method for making and using such devices also is provided. The preferred polymer is a copolymer of a halogenated vinylidene and a halogenated alkene.

The invention relates to a method for preparing a wound hemostatic bag and porous hemostatic agent particles. Effective components of a hemostatic agent comprise one or more of zeolite powder, kaolinpowder and bentonite powder, the effective components of the hemostatic agent and a water-soluble adhesive are added with calcium bicarbonate, and are granulated, particles are dried at the temperature of 90-150 DEG C, thus, the porous hemostatic agent particles are prepared, and the porous hemostatic agent particles are packaged in a hydrophilic bag to prepare the wound hemostatic bag. The poroushemostatic agent particles have compact pore channels, and are good in water absorption and permeability, a water-soluble adhesive dissolves when meeting water in blood, the effective contact area between the hemostatic agent as well as calcium carbonate and blood is increased, coagulation reaction is accelerated, and thrombosis is promoted. The wound hemostatic bag is good in hemostatic effect,the hemostatic bag can be removed after hemostasis, and then hemostatic bag can be carried out.

The invention relates to a medical apparatus, in particular to a nanometer electrospinning fiber stent for intravascular interventional therapy of intracranial aneurysm. The fiber stent comprises a stent body and a pushing device, wherein the stent body is of a cylindrical net-shaped structure which is formed by weaving a nickel-titanium alloy wire, and the two ends of the stent body are respectively provided with four X-ray-opaque marking points, so as to ensure the accurate release of the stent; the surface of the middle section of the stent body is attached with a large amount of nanometer electrospinning fibers, and the starting point and the finish point of the middle section attached with the nanometer electrospinning fibers are respectively provided with two X-ray-opaque marking points, so as to assist the development positioning in the stent release process, and ensure that the middle section can completely cover an aneurysm neck in the stent releasing process. The fiber stent has the advantages that the dynamics of blood in the intracranial aneurysm can be changed, the formation and organization of thrombus in the aneurysm, and the regeneration of skin cells in blood vessels of the aneurysm neck are promoted, and the purpose of reconstructing an aneurysm-carrying artery is realized; meanwhile, the smoothness of the aneurysm-carrying artery and branch arteries is maintained.

The invention provides a medical implant and a manufacturing method thereof. The medical implant comprises a spring ring, the spring ring comprises a first spring ring unit and a second spring ring unit, and the first spring ring unit is connected with the second spring ring unit; the outer surface of the first spring ring unit is located on a first curved surface, and the concave side of the first curved surface is arranged towards the second spring ring unit. The medical implant is used for blocking treatment of hemangioma, the first spring ring unit can adapt to the shape of the tumor wall of the hemangioma, the compactness of intra-tumor embolism is improved, and the treatment effect is improved.

Embodiments of the present invention provide an improved vascular occlusion device for occlusion of a passageway, cavity, or the like. According to one embodiment, a medical device for occluding a left atrial appendage is provided. The medical device includes a first portion having at least one plane of occlusion that is configured to be positioned outside of the left atrial appendage, and a second portion having at least one plane of occlusion that is configured to be at least partially positioned within a cavity defined by the left atrial appendage.

The invention discloses a central venous catheter capable of preventing thrombus. The central venous catheter comprises a central venous catheter body and medical coating layers coating the walls of the catheter. Each medicine coating layer comprises medicine and a medicine carrier, wherein the medicine is tissue factor pathway inhibitor TFPI-1 or TFPI-2, and the mass ratio of the medicine to the medicine carrier is 1:(4-7.9). Both the inner wall and the outer wall of the catheter body are coated with the medicine coating layers. The thickness of the medicine coating layers is 20-40 micrometers. The central venous catheter has the advantages that the tissue factor pathway inhibitor is applied to the central venous catheter body, so that thrombogenesis and bacterial infection in the central venous catheter body are effectively prevented, the pain and burden of a patient are reduced, the workload of medical staff is reduced, and working efficiency is improved. The tissue factor pathway inhibitor is tissue factor physiological inhibitor, has good blood compatibility and tissue compatibility compared with other medicine, has no toxic or side effect and has few influences on the human body.

The invention relates to a surgical assembly capable of preventing endoleak and provided with a spring coil and a chimney stent. A first support frame is arranged in a main body stent; a first film wraps the first support frame; the main body stent is of a round structure, and a groove for wrapping the chimney stent is defined after the side face of the main body stent is pressed; first artificialfibers are arranged on the part, making contact with the chimney stent, of the groove; a second support frame is arranged in the chimney stent, and a second film wraps the second support frame; second artificial fibers are arranged in the longitudinal direction of the spring coil; the spring coil is wound around the chimney stent; and the chimney stent and the spring coil are implanted into the groove of the main body stent via a stent implanting device. According to the surgical assembly provided by the invention, endoleak can be effectively prevented, complete closure of graft pathologicalarteries can be achieved and the occurrence of complications can be reduced.

The invention discloses a special model-fitting modularized occluder for promoting thrombosis of a pseudocoele of an aortic dissection. The special model-fitting modularized occluder is of a three-piece structure. The special model-fitting modularized occluder comprises a dissection pseudocoele proximal end occluding member, a pseudocoele middle occluding member and a pseudocoele distal end occluding member, wherein combinations of different components are selectively applied and combined and used in service according to breaks of different types of a distal end of the aortic dissection. The invention provides the special model-fitting modularized surface-modified coagulant occluder for clinics, the occluder can be applicable to pseudocoele of various shape characteristics, the thrombosisand reconstruction of the pseudocoele are effectively promoted, and the application is extensive; and an appropriate model can be selected according to the shape and size of the pseudocoele, so that the economic burden is alleviated, and the surgical operation time is shortened. Simultaneously, a special release system is designed to achieve accurate release and reduce injury to the pseudocoele, so that the aims of better promoting the thrombosis action of the pseudocoele, improving forward treatment effect on the pseudocoele and improving global prognosis of the dissection are achieved.

The invention discloses a nano-gold photothermal effect targeted drug delivery complex lipidosome based on polymer modification, an implementation method of the lipidosome and an application of the lipidosome. The complex lipidosome comprises a polymer modified lipidosome, nano-gold particles and procoagulant and antiplasmin targeted drugs, wherein the nano-gold particles and the procoagulant andantiplasmin targeted drugs are arranged in the lipidosome. Photothermal effects and hemodynamic response are effectively combined, polymerization of the lipidosome into a vesicle with the diameter of80-200 micrometers is promoted by local photothermy generated by the nano-gold particles, blood vessels are effectively blocked, targeted release and stay of the drugs are realized by physical properties of lipid membranes, thrombosis is accelerated, and complete blockage of the blood vessels is ensured.

The invention provides a medical implant and a medical device. The medical device comprises the medical implant, and the medical implant comprises a plugging part and a thrombosis promoting coating; the plugging part is of a curved surface structure and is used for being arranged at an opening of a target object. The plugging part comprises a supporting body and a covering film attached to the supporting body, and the thrombosis promoting coating is formed on at least partial area of the surface, closest to the inner cavity of the target object, of the covering film. For example, if the target object is an aneurysm, when the medical implant is arranged at the neck opening of the aneurysm, the thrombosis promoting coating is arranged towards the aneurysm cavity, thrombosis of the aneurysm can be promoted, the aneurysm cavity does not need to be filled with an embolism spring ring, and the risk that the embolism spring ring falls off to cause thrombus is avoided; and regrowth of the aneurysm is not caused.

The invention provides an embolism which comprises an embolism body, the embolism body is a spiral component, the embolism body is made of polylactic acid-glycolic acid copolymer, and the proportion of lactic acid is 80%-85% by weight, so that the degradation time of the embolism body at a preset temperature is longer than 6 months. The preset temperature is the body cavity temperature of a patient, and after the embolism is implanted into a tumor cavity of hemangioma, the degradation time of the embolism body adapts to the time of tumor cavity mechanization and tumor neck endothelialization, so that hemangioma recanalization can be effectively avoided, and the occupation effect is relieved or even removed after the embolism body is completely degraded.

The invention provides an intracavity plugging device, the intracavity plugging device comprises a net-shaped framework which is of a hollow structure and comprises two end faces and a side face connected between the two end faces; a flow choking film formed on the net-shaped framework, wherein the flow choking film comprises two end faces and a side face connected between the two end faces; and a plugging promoting piece formed on the surface of the intracavity plugging device; wherein the side face of the net-shaped framework and/or the side face of the flow blocking film are/is a concave-convex surface. The intracavitary plugging device is small in size after being compressed, can be quickly released to plug a false cavity, and can promote thrombosis of the false cavity.

Navigation and tissue capture systems and methods for navigation to and/or capture of selected tissue using the innate electrical activity of the selected tissue and/or other tissue are described. In the context of left atrial appendage closure, the systems and methods can be used to navigate to the left atrial appendage and capture/control the appendage while a closure instrument (suture, clip, ring) is placed over the appendage and tightened down or a closure method (ablation, cryogenic procedures, stapling, etc.) is performed to close the left atrial appendage. The use of innate electrical activity for navigating devices may be used in connection with other tissues and/or areas of the body.