Embolism object

An embolism and embolization technology, applied in the field of medical devices, can solve problems such as inability to effectively alleviate space occupation effects

Pending Publication Date: 2022-03-15
NEUROGUARD MEDICAL (SHANGHAI) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, clinical data show that in the case of using stents, the endothelialization time is about 6 months, so when using these biomodified coil products for interventional treatment of aneurysms, if the volume ratio of polymer materials in the product is relatively low High, when the polymer material is completely degraded, the fibrous tissue in the tumor cavity has not been fully organized, and the decrease in embolism density caused by the degradation of the polymer material has the risk of aneurysm recanalization, but if the polymer material in the product The volume ratio is small, and the mass effect cannot be effectively alleviated after the tumor cavity is fully organized

Method used

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Examples

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Effect test

Embodiment 1

[0045] Embodiment 1: A plug body 110 prepared in the embodiment of the present invention was placed in PBS buffer at 37°C to perform a degradation experiment. figure 2 A graph showing the mass / weight average molecular weight loss of the plug body 110 versus degradation time is shown. refer to figure 2 , in the initial stage of degradation (1-200 days), the mass loss of the plug body 110 is not obvious, and the plug body 110 basically maintains the integrity of the overall structure (such as image 3 shown). When the degradation proceeds to 200-300 days, the loss of the mass and weight-average molecular weight of the plug body 110 basically reaches 50%, and the overall integrity of the plug body 110 is destroyed (such as Figure 4 shown). From the beginning of degradation to about 340 days, the correlation equation between the logarithm Y of the weight average molecular weight of the plug body 110 and the time X is: Y=-0.0175X+13.772, and the correlation coefficient R 2 i...

Embodiment 2

[0046] Example 2: Put another plug body 110 prepared in the embodiment of the present invention in PBS buffer at 50°C for a degradation experiment, and take scanning electron micrographs of the plug body on the 14th and 56th days of degradation. Such as Figure 5 As shown, when the degradation progressed to the 14th day, the degradation of the plug body 110 was not significant, and the overall integrity was substantially maintained. Such as Figure 6 As shown, when the degradation progressed to the 56th day, the structural integrity of the plug body 110 was destroyed, and the intrinsic viscosity and weight-average molecular weight of the plug body 110 both lost more than 50%, which basically conformed to the first-order degradation law. When the degradation lasts for more than 8 months, the appearance of the plug body 110 is observed and it is found that the plug body is basically completely degraded.

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Abstract

The invention provides an embolism which comprises an embolism body, the embolism body is a spiral component, the embolism body is made of polylactic acid-glycolic acid copolymer, and the proportion of lactic acid is 80%-85% by weight, so that the degradation time of the embolism body at a preset temperature is longer than 6 months. The preset temperature is the body cavity temperature of a patient, and after the embolism is implanted into a tumor cavity of hemangioma, the degradation time of the embolism body adapts to the time of tumor cavity mechanization and tumor neck endothelialization, so that hemangioma recanalization can be effectively avoided, and the occupation effect is relieved or even removed after the embolism body is completely degraded.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to an embolism. Background technique [0002] Intracranial aneurysm is a common cerebrovascular disease, which is caused by a variety of factors to destroy the structure of the intracranial artery wall and abnormal bulge of the wall, and is one of the important causes of subarachnoid hemorrhage. In recent years, with the advancement of imaging and materials science, the rapid development of interventional treatment of intracranial aneurysms has been promoted, and coil embolization is a common treatment method. Coil embolization of aneurysms, on the one hand, can reduce the impact of blood flow on the aneurysm wall, on the other hand, it can induce thrombus formation and thrombus organization in the aneurysm cavity, and realize the occlusion of the aneurysm. [0003] Clinical studies have found that a high proportion of large and giant aneurysms are caused by mass effect. A...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/12A61L31/06A61L31/14
CPCA61B17/12113A61B17/12145A61B17/1215A61L31/06A61L31/148A61B2017/00004A61B2017/0092A61B2017/00867
Inventor 张朔杨瑞郭远益钱少君余画
Owner NEUROGUARD MEDICAL (SHANGHAI) CO LTD
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