Method for preparing strontium-containing biological composite material based bone bracket
A composite material and bone scaffold technology, applied in the field of 3D printing, can solve the problems of slow repair of bone defects and difficult to heal, and achieve the effects of good biocompatibility, suitable degradation rate, and good osteogenic induction ability.
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[0031] The invention discloses a method for preparing a strontium-containing biological composite material, which is formed by cross-linking a biological inorganic material and a strontium alginate composite slurry through a solution containing strontium ions. The biological inorganic material is a biological ceramic and a biological glass. The strontium ion-containing solution includes but not limited to strontium chloride solution and strontium nitrate solution. The specific steps include:
[0032] Step 1: Prepare sodium alginate solution;
[0033] Step 2: Add the bio-inorganic material powder to the sodium alginate solution in multiple times and disperse uniformly to obtain the bio-inorganic material-sodium alginate suspension;
[0034] Step 3: Cross-link the bio-inorganic material-sodium alginate suspension obtained in step 2 with a solution containing strontium ions, the cross-linking time is more than 1 min, and the cross-linking temperature is controlled to 4-80°C to obtain a ...
Example Embodiment
[0048] Example 1
[0049] Weigh 1g of sodium alginate powder and 30g of distilled water, mix the two with a magnetic stirrer for 1 hour to obtain a uniformly dispersed sodium alginate solution; then weigh 26g of nano-sized hydroxyapatite powder and add it to the sodium alginate solution Ball milling is carried out to obtain the hydroxyapatite-sodium alginate composite slurry; then the hydroxyapatite-sodium alginate composite slurry is added to the extrusion deposition 3D printer to print the three-dimensional porous scaffold, and the printed scaffold is quickly placed in 5wt. Cross-linked in %SrCl2 solution for 24 hours; the cross-linked stent is fully dried and then placed in a muffle furnace for sintering. The heating rate and cooling rate are 5°C / min, and the temperature is kept at 1200°C for 2 hours. Strontium is obtained after sintering Hydroxyapatite porous scaffold (as attached figure 1 Shown).
Example Embodiment
[0050] Example 2
[0051] Weigh 0.5g of sodium alginate powder and 30g of distilled water, mix the two with a mechanical stirrer for 1 hour to obtain a uniformly dispersed sodium alginate solution; then weigh 20g of nanometer calcium silicate powder and add it to the sodium alginate solution Carry out ball milling to obtain calcium silicate-sodium alginate composite slurry; next, the calcium silicate-sodium alginate composite slurry is cryogenically treated with liquid nitrogen and then freeze-dried, and the freeze-dried porous scaffold is placed in a 10wt% SrCl2 solution Cross-linking for 24 hours; the cross-linked stent is fully dried, and then placed in a microwave sintering furnace for sintering. The heating rate and cooling rate are 10°C / min, and the temperature is kept at 1000°C for 1 hour. After sintering, strontium-containing calcium silicate is obtained Porous scaffold.
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