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Method for preparing strontium-containing biological composite material based bone bracket

A composite material and bone scaffold technology, applied in the field of 3D printing, can solve the problems of slow repair of bone defects and difficult to heal, and achieve the effects of good biocompatibility, suitable degradation rate, and good osteogenic induction ability.

Inactive Publication Date: 2019-01-29
NANCHANG UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

In childhood, osteogenesis is very active, and osteogenesis is stronger than osteoclastic behavior, and new bone is continuously generated; in adulthood, the functions of the two are in a dynamic balance, and once bone damage occurs, the activity of osteogenesis in the periosteum is suppressed again. Reawakening, the osteogenic behavior at this time will be stronger than the osteoclastic behavior, thereby promoting the healing of the bone defect; however, if the defect exceeds a critical size, the bone defect will not be able to repair itself or the repair will be very slow; with the arrival of old age, the fracture The function of bone is getting stronger and stronger, and the bone-breaking behavior is stronger than the bone-forming behavior, which begins to lead to osteoporosis, and it is difficult to heal even if bone damage occurs

Method used

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  • Method for preparing strontium-containing biological composite material based bone bracket
  • Method for preparing strontium-containing biological composite material based bone bracket

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preparation example Construction

[0031] The invention discloses a method for preparing a strontium-containing biocomposite material, which is formed by cross-linking a bioinorganic material and a strontium alginate composite slurry through a solution containing strontium ions, and the bioinorganic material is bioceramic and bioglass One or more; the solution containing strontium ions includes but not limited to strontium chloride solution, strontium nitrate solution, and the specific steps include:

[0032] Step 1: preparing sodium alginate solution;

[0033] Step 2: adding the bio-inorganic material powder into the sodium alginate solution several times and dispersing evenly to obtain the bio-inorganic material-sodium alginate suspension;

[0034] Step 3: Cross-link the bio-inorganic material-sodium alginate suspension obtained in step 2 with a solution containing strontium ions. The cross-linking time is more than 1 min, and the cross-linking temperature is controlled at 4-80°C to obtain a strontium-contain...

Embodiment 1

[0049]Weigh 1g of sodium alginate powder and 30g of distilled water, mix them with a magnetic stirrer for 1 hour to obtain a uniformly dispersed sodium alginate solution; then weigh 26g of nano-sized hydroxyapatite powder and add it to the sodium alginate solution Perform ball milling to obtain the hydroxyapatite-sodium alginate composite slurry; then add the hydroxyapatite-sodium alginate composite slurry to an extrusion deposition 3D printer to print a three-dimensional porous scaffold, and the printed scaffold is quickly placed in a 5wt Cross-link in %SrCl2 solution for 24 hours; the cross-linked scaffold is fully dried, and then placed in a muffle furnace for sintering, the heating rate and cooling rate are 5°C / min, 1200°C for 2 hours, and the strontium-containing scaffold is obtained after sintering. The porous hydroxyapatite scaffold (as attached figure 1 shown).

Embodiment 2

[0051] Weigh 0.5g of sodium alginate powder and 30g of distilled water, mix the two with a mechanical stirrer for 1 hour to obtain a uniformly dispersed sodium alginate solution; then weigh 20g of nano-scale calcium silicate powder and add it to the sodium alginate solution Perform ball milling to obtain calcium silicate-sodium alginate composite slurry; then freeze-dry the calcium silicate-sodium alginate composite slurry with liquid nitrogen cryogenic treatment, and place the freeze-dried porous scaffold in 10wt% SrCl2 solution Cross-link for 24 hours; the cross-linked scaffold is fully dried, and then placed in a microwave sintering furnace for sintering. The heating rate and cooling rate are 10°C / min, and the temperature is kept at 1000°C for 1 hour. After sintering, strontium-containing calcium silicate is obtained. Porous scaffold.

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Abstract

The invention relates to the technical field of 3D printing and particularly relates to a method for preparing a strontium-containing biological composite material based bone bracket. The method comprises the specific steps: (1) preparing a sodium alginate solution; (2) adding biological inorganic material powder into the sodium alginate solution in multiple times, and carrying out homogeneous dispersion, so as to obtain a biological inorganic material-sodium alginate suspension; and (3) subjecting the biological inorganic material-sodium alginate suspension obtained in the step (2) to crosslinking for 1min or more with a solution containing strontium ions while controlling the crosslinking temperature to 4 DEG C to 80 DEG C, thereby obtaining a strontium-containing biological composite material. According to the strontium-containing biological composite material and the preparation method therefor, provided by the invention, the porous strontium-containing biological composite material for bone repair has good biocompatibility, appropriate degradation rate and good osteogenesis induction capability, the clinical requirements of bone-defection regeneration repair materials on performance are met, and the clinical application of the strontium-containing biological composite material is promoted.

Description

technical field [0001] The invention relates to the technical field of 3D printing, in particular to a method for preparing a bone scaffold based on strontium-containing biocomposite materials. Background technique [0002] The mechanism of new bone formation and bone defect tissue reconstruction is very complex, but it can be simply understood as the interaction between osteoblasts and osteoclasts. In childhood, osteogenesis is very active, and osteogenesis is stronger than osteoclastic behavior, and new bone is continuously generated; in adulthood, the functions of the two are in a dynamic balance, and once bone damage occurs, the activity of osteogenesis in the periosteum is suppressed again. Reawakening, the osteogenic behavior at this time will be stronger than the osteoclastic behavior, thereby promoting the healing of the bone defect; however, if the defect exceeds a critical size, the bone defect will not be able to repair itself or the repair will be very slow; with...

Claims

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Application Information

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IPC IPC(8): C04B35/22C04B35/447C04B35/626C04B38/00B28B1/00B33Y70/00
CPCB28B1/001B33Y70/00C04B35/22C04B35/447C04B35/62605C04B38/00C04B2235/3213C04B2235/6026
Inventor 周奎晏金超徐治冬武言艾凡荣曹传亮李文超刘东雷王文琴
Owner NANCHANG UNIV
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