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Nano-gold photothermal effect targeted drug delivery complex lipidosome based on polymer modification, implementation method of lipidosome and application of lipidosome

A polymer and thermal effect technology, applied in the field of biomedicine, can solve the problems of non-targeted gold nanoparticles, reduced treatment effect, thrombus blockage, etc., to achieve the effect of inhibiting fibrinolysis, promoting thrombus formation, and ensuring complete blockage

Pending Publication Date: 2020-01-17
XI AN JIAOTONG UNIV
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Problems solved by technology

However, the flow of unmodified gold nanoparticles in blood vessels has no targeting function, and will not stay in the diseased blood vessel area for a long time, but will be gradually metabolized by organisms with the flow of venous blood, reducing the structure's treatment effect
Therefore, it is difficult to form thrombus to block blood vessels simply by photothermal reaction.

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  • Nano-gold photothermal effect targeted drug delivery complex lipidosome based on polymer modification, implementation method of lipidosome and application of lipidosome
  • Nano-gold photothermal effect targeted drug delivery complex lipidosome based on polymer modification, implementation method of lipidosome and application of lipidosome
  • Nano-gold photothermal effect targeted drug delivery complex lipidosome based on polymer modification, implementation method of lipidosome and application of lipidosome

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Embodiment Construction

[0037] see figure 1 , the present invention is based on a polymer-modified nano-gold photothermal effect targeted drug delivery composite liposome, including liposomes, nano-gold particles and procoagulant and anti-fibrinolytic targeted drugs, nano-gold particles and pro-coagulant and anti-fibrinolytic drugs. The fibrinolytic targeting drug is provided in liposomes.

[0038] Prepare nano-gold rods with a length of 79.5±10.5nm, a diameter of 13.5±0.9nm, and an average aspect ratio of 5.89. The maximum absorption wavelength is 1053-1150nm, which is close to the wavelength of 1064nm Nd:YAG laser, and the concentration is 4.2-4.60mg / kg Encapsulated in liposomes.

[0039]Thrombin participates in the synthesis of coagulation factors and promotes thrombus formation by converting fibrinogen into fibrin. Tranexamic acid can inhibit the disappearance of thermal coagulation by blocking the combination of plasmin and fibrin. Procoagulant and antifibrinolytic targeting drugs are encapsu...

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Abstract

The invention discloses a nano-gold photothermal effect targeted drug delivery complex lipidosome based on polymer modification, an implementation method of the lipidosome and an application of the lipidosome. The complex lipidosome comprises a polymer modified lipidosome, nano-gold particles and procoagulant and antiplasmin targeted drugs, wherein the nano-gold particles and the procoagulant andantiplasmin targeted drugs are arranged in the lipidosome. Photothermal effects and hemodynamic response are effectively combined, polymerization of the lipidosome into a vesicle with the diameter of80-200 micrometers is promoted by local photothermy generated by the nano-gold particles, blood vessels are effectively blocked, targeted release and stay of the drugs are realized by physical properties of lipid membranes, thrombosis is accelerated, and complete blockage of the blood vessels is ensured.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a polymer-modified nano-gold photothermal effect targeted drug delivery release composite liposome and its implementation method and application. Background technique [0002] Port Wine Stains (PWS), also known as port wine stains, is a common congenital capillary malformation in the dermis, composed of many abnormally dilated capillaries, and the incidence rate in newborns is about 0.3% ~0.5%, mainly in obvious parts such as face and neck. With age, most PWS will not subside by itself, but will gradually darken and thicken, seriously affecting the mental health of patients. [0003] In the past, the treatment of PWS diseased blood vessels mainly relied on the interaction between laser and tissue to form thrombus to block blood vessels, cause local ischemia, and promote the apoptosis of diseased blood vessels. However, for large-sized blood vessels that are deep...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K41/00A61K45/00A61P9/00A61P17/00
CPCA61K9/1271A61K9/127A61K9/1277A61K41/0052A61K45/00A61P9/00A61P17/00
Inventor 陈斌李东张倩倩贾浩邢林庄
Owner XI AN JIAOTONG UNIV
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