Hydrogel containing coenzyme Q10, and cataplasm prepared by hydrogel

A technology of hydrogel and preparation, applied in the field of preparation carrier form of coenzyme Q10, can solve the problems of oxidation and decomposition, great influence on product quality and use effect, and decrease in content of coenzyme Q, etc.

Inactive Publication Date: 2012-04-04
JIANGSU KANGBEIDE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] But since coenzyme Q 10 The molecular structure contains unsaturated double bonds, so it is extremely unstable, and it is easily oxidized and decomposed by oxygen and light in the air. When it is heated or encounters metal ions, the decomposition is accelerated, and the result often leads to coenzyme Q in the product. 10 Decreased content will have a great impact on product quality and use effect

Method used

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  • Hydrogel containing coenzyme Q10, and cataplasm prepared by hydrogel
  • Hydrogel containing coenzyme Q10, and cataplasm prepared by hydrogel
  • Hydrogel containing coenzyme Q10, and cataplasm prepared by hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Preparations Containing Coenzyme Q 10 Nanoparticle hydrogel and cataplasm containing the hydrogel

[0064] In this example, the preparation containing Q 10 The hydrogel and cataplasm of polypeptide-chitosan composite nanoparticles were taken as an example to prepare coenzyme Q 10 A hydrogel of nanoparticles and a cataplasm containing the hydrogel will be described.

[0065] Coenzyme Q is prepared in this embodiment 10 The method for the polypeptide-chitosan composite nanoparticle can refer to CN101530394B.

[0066] First prepare the coenzyme Q-containing 10 Polypeptide-chitosan composite nanoparticles. The main auxiliary material used in the preparation of nanoparticles in the present invention is poly(L-glutamic acid-γ-benzyl ester)-polyethylene glycol block copolymer (PBLG-b-PEG), and its preparation method is as follows:

[0067] 2.5 mg of PBLG-b-PEG block copolymer and 3 mg of coenzyme Q 10 The mixture was dissolved in 25 mL of dimethylformamide: tetrahydrofu...

Embodiment 2

[0084] Preparations Containing Coenzyme Q 10 Hydrogel of flexible nano liposome and cataplasm containing the hydrogel.

[0085] This example uses egg yolk lecithin as the main membrane material rice to prepare coenzyme Q 10 Flexible nanoliposome, its preparation method is as follows: Weigh respectively 2.25g egg yolk lecithin, 0.36g cholesterol, 1.62g Tween 80, place in 250mL round bottom flask, add 20mL ether to make it dissolve, then the round bottom The flask was connected to a rotary decompression evaporator, and evaporated under reduced pressure for 30 minutes to remove the organic solvent therein until the dry lipid film was deposited on the wall of the bottle, and then 5 mL of ether was added to the round-bottomed flask, and the round-bottomed flask was shaken until it was deposited on the The dry lipid film on the wall of the flask was completely peeled off and dissolved. Then accurately weigh 30mg of coenzyme Q 10 and 0.36g sodium cholate, add 10mL deionized water,...

Embodiment 3～7

[0090] Coenzyme Q selected in the hydrogel described in Examples 3-7 and the cataplasm containing the hydrogel 10 The flexible nanoliposome is the same as in Example 2.

[0091]

[0092]

[0093] Coenzyme Q described in the above-mentioned Examples 3-7 10 Coenzyme Q contained in flexible nanoliposomes in embedded and free states 10 The content of the above-mentioned companies were respectively carried out, the results are as follows:

[0094] coenzyme Q 10 content Example 3 Example 4 Example 5 Example 6 Example 7 Embedded Coenzyme Q 10 content 0.05％ 0.05％ 0.05％ 0.063％ 0.063％ free coenzyme Q 10 content 0.061％ 0.061％ 0.061％ 0.077％ 0.077％ total coenzyme Q 10 content 0.111％ 0.111％ 0.111％ 0.14％ 0.14％

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Abstract

The present invention relates to a hydrogel containing coenzyme Q10 and a cataplasm prepared by the hydrogel. The coenzyme Q10 of the present invention is prepared into nanoparticles, solid lipid nanoparticles, flexible nano-liposomes, nano-microemulsion, nano-micelles and the like. Especially that the flexible coenzyme Q10 nano-liposomes are preferably adopted in the hydrogel of the present invention. The coenzymes Q10 with various forms are adopted to prepare the hydrogel, the cataplasm prepared by the hydrogel, and other external application preparations or apparatuses. In the prior art, the coenzyme Q10 in the common external application preparation containing the coenzyme Q10 is easily oxidized and decomposed, and is preserved difficultly. With the present invention, the problems in the prior art are effectively solved; the skin penetration performance of the coenzyme Q10 is substantially increased. The hydrogel and the cataplasm prepared by the hydrogel can be applicable for dermal topical application and nursing of the coenzyme Q10, or percutaneous systematic administration of the coenzyme Q10, specifically for preparation into cosmetics, health products, or drugs and the like. The present invention further relates to a use of the coenzyme Q10 nano-preparation in preparation of the coenzyme Q10 hydrogel preparation.

Description

technical field [0001] The present invention relates to containing coenzyme Q 10 The hydrogel and the cataplasm containing the hydrogel, wherein the coenzyme Q 10 The existing forms are nano-preparation carrier forms made by nanotechnology such as nanoparticles, solid lipid nanoparticles, flexible nano-liposomes, nano-microemulsions, and nano-micelles. Preferably, flexible nano-liposomes are used as the coenzyme Q in the present invention. 10 formulation carrier form. Background technique [0002] Traditional medicinal substances, such as plant tissue extracts, animal tissue extracts, natural minerals, etc. are made into various pastes, ointments or various soft and hard plasters for local administration, which have been widely used in various countries. Like my country's traditional rubber plaster, there are also records of hard plaster in "Eber's Papyrus" (BC1552) in Egypt and the Kingdom of Babylon. Modern transdermal patches have developed rapidly since their appearanc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K9/70A61K31/122A61K47/30A61K47/32A61K47/42
Inventor 王树明孙莺
Owner JIANGSU KANGBEIDE PHARMA
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