Adhesive patch

Abstract

A patch agent of the present invention comprises a support, and an adhesive layer laid on the support and containing an adhesive base and a drug, wherein the adhesive base contains an acrylic polymer substantially having no carboxyl and no hydroxyl in molecules thereof, and a rubber-based polymer, so as to achieve sufficiently high skin permeability of the drug and preparation properties. Accordingly, the present invention enables administration of the drug through skin to be implemented with drug administration effect at a sufficiently high level and on a stable basis.

Description

technical field [0001] The present invention relates to a patch, and more specifically, to a patch using an acrylic polymer and a rubber-based polymer as an adhesive matrix. Background technique [0002] Oral administration using tablets, capsules, syrups, etc. has been known in the past as methods for administering drugs, but in recent years attempts have been made to administer these drugs using patches. The administration method using patches not only solves the problems in the oral method, but also has the advantages of reducing the frequency of administration, improving compliance, and being easy to administer or stop administration, so it is particularly expected as a drug for the elderly or children. medicine law. [0003] However, the stratum corneum of normal skin has a barrier function to prevent foreign substances from invading the body, and the medicinal ingredients usually mixed in the matrix of the patch cannot obtain sufficient transdermal absorption in most ...

AI Technical Summary

Problems solved by technology

For example, although rubber-based polymers with relatively low drug solubility have high transdermal absorbability of drugs, the amount of drug that can be contained is limited, so the rate of drug absorption tends to decrease during sticking, and as a result, the blood drug concentration sometimes decreases. Unable to obtain sustained effect (New Drugs and Clinics, 48, 1015-1-24, 1993)

In addition, rubber-based polymers tend to cause crystallization of the drug in the preparation over time due to low solubility of the drug, and sufficient stability may not be obtained in some cases.

[0006] In addition, although acrylic polymers have higher drug solubility than rubber-based polymers, drug absorption is low

Therefore, in order to obtain the necessary drug absorption in a patch using an acrylic polymer, it is necessary to increase the concentration of the drug, so that sufficient physical properties of the preparation may not be obtained or the cost may increase during preparation.