Use of levo-ornidazole for preparing anti-parasitic-infectious drug

A technology for anti-parasitic infection and L-ornidazole, which is applied in the field of application of L-ornidazole in the preparation of anti-parasitic infection drugs, and can solve the problems of undisclosed drug efficacy and activity differences, pharmacological efficacy comparison research, etc.

Active Publication Date: 2005-12-21
NANJING SANHOME PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is a patent application for left-ornidazole (see CN 1400312A) obtained from the ornidazole racemate by enzymatic separation in China, but there is no pharmacological treatment of left-, right-ornidazole and racemic ornidazole. comparative efficacy studies, and never disclosed the difference between their pharmacodynamic activities

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The prescription consists of:

[0021] (a) L-ornidazole 250mg / tablet

[0022] (b) Pregelatinized starch 80mg / tablet

[0023] (c) Sodium carboxymethyl starch 4mg / tablet

[0024] (d) Magnesium stearate 3mg / tablet

[0025] Taking the production of 1000 L-ornidazole tablets as an example, the specific preparation method is: first pass the raw and auxiliary materials through a 100-mesh sieve, weigh the prescribed amount of L-ornidazole and pregelatinized starch and mix evenly, add 8% starch slurry Making soft material, granulating, drying, granulating, adding prescription amount of sodium carboxymethyl starch and magnesium stearate to the granules, pressing into tablets, and coating with 8% Opadry 95% ethanol solution.

Embodiment 2

[0027] Prescription composition:

[0028] (a) L-Ornidazole 250mg / capsule

[0029] (b) Starch 45mg / grain

[0030] (c) Magnesium stearate 2mg / capsule

[0031] Take the preparation of 1000 L-ornidazole capsules as an example. The specific preparation method is to pass the raw and auxiliary materials through a 100-mesh sieve, weigh the prescription amount of L-ornidazole and starch, mix evenly, add 6% starch slurry to make soft materials, granulate, dry, granulate, and add the prescription to the granules. The amount of magnesium stearate is mixed evenly, and the capsules are filled.

Embodiment 3

[0033] Prescription composition:

[0034] (a) L-Ornidazole 250mg / bag

[0035] (b) Mannitol 250mg / bag

[0036] (c) Sucrose 200mg / bag

[0037] (d) Sodium carboxymethyl starch 20mg / bag

[0038] Take the preparation of 1000 bags of L-ornidazole granules as an example. The specific preparation method is to first pass the raw and auxiliary materials through a 100-mesh sieve, weigh the prescription amount of L-ornidazole, mannitol, powdered sugar and sodium carboxymethyl starch, mix evenly, add 8% starch slurry to make a soft material, granulate, and dry Dried, whole, packaged.

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PUM

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Abstract

The present invention provides an application of levo-orinidazole in preparation of medicine for resisting parasitization. The tests show that the levo-orinidazole is superior to dextro-orinidazole and racemic orinidazole in therapeutic action for curing parasitization (special for curing infection of trichomonas vaginalis and cecal amebic infection). Said invention also relates to the conventional dosage forms for clinical application, including oral preparation, venous administration preparation and vaginal medication preparation, etc.

Description

technical field [0001] The present invention relates to the application of L-ornidazole in the preparation of medicines for anti-parasitic infection, in particular to making L-ornidazole into a dosage form suitable for clinical use and used for anti-parasitic infection, especially Trichomonas vaginalis infection and cecal albinism For Meaba infection, the dosage forms preferably include oral preparations, intravenous preparations and vaginal preparations. Background technique [0002] Levo-ornidazole (1-(3-chloro-2-S-(-)hydroxypropyl)-2-methyl-5-nitroimidazole) is Ornidazole (Ornidazole, CAS 16773-42-5) Ornidazole is a nitroimidazole derivative. It is a powerful anti-anaerobe and anti-protozoal infection drug. A third-generation nitroimidazole derivative with wider distribution in the body. The antimicrobial effect of ornidazole is through the reduction of the nitro group in its molecule to an amino group in an oxygen-free environment, or through the formation of free radi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/20A61K9/48A61K31/4164
CPCA61K9/0019A61K9/0034A61K9/0036A61K9/2059A61K9/4866A61K31/4164A61K31/4168A61P33/00A61P33/02A61P33/14Y02A50/30
Inventor 张仓陶小鑫
Owner NANJING SANHOME PHARMACEUTICAL CO LTD
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