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Multifunctional microemlusion gel preparation and preparation process thereof
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A microemulsion gel, multi-functional technology, applied in the field of medicine, can solve problems such as affecting product quality, achieve good penetration effect, improve safety, and increase the effect of cumulative penetration
Inactive Publication Date: 2014-03-26
CHINA PHARM UNIV
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At present, there are related patents such as Granisetronhydrochloridemicroemulsion gel and its preparation method (CN101933902A), a kind of Oxiconazole nitratemicroemulsiongel preparation (CN102423293A), but these patents generally include chemical penetration enhancers, The addition of traditional preservatives affects product quality
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[0056] (1) Weigh 5g of ethyl oleate, 20g of polyoxyethylene hydrogenated castor oil, 40025g of polyethylene glycol, and 1g of diclofenac sodium, mix well, add water and stir for 40min to obtain transparent microemulsion A.
[0057] (2) Weigh 9801g of carbomer and 0.1g of chitosan, stir in water for 60min, swell for 12h, then mix, stir evenly, adjust pH to 6-8, and obtain transparent gel B.
[0058] (3) Mix liquid A and gel B, stir evenly, and get ready.
Embodiment 2
[0059] Embodiment 2 ibuprofen microemulsion gel preparation, component is as follows:
[0060]
[0061]
[0062] The preparation method is as follows:
[0063] (1) Weigh 4g isopropyl myristate, polysorbate 8020g, 1,2-propylene glycol 25g, ibuprofen 3g, mix well, add water and stir for 40min, weigh polylysine 0.1g and add, stir for 10min, Promptly obtain transparent microemulsion A liquid.
[0064] (2) Weigh carbomer ETD20201g, stir in water for 60min, swell for 12h, then mix, stir evenly, adjust pH to 6-8, and obtain transparent gel B.
[0065] (3) Mix liquid A and gel B, stir evenly, and get ready.
Embodiment 3
[0066] Embodiment 3 Menthol microemulsion gel preparation, component is as follows:
[0067]
[0068] The preparation method is as follows:
[0069] (1) Weigh 4g of medium-chain fatty acidtriglyceride, 25g of caprylic acid / capric acid macrogolglyceride, 3g of polyglycerol-2 oleate, 0.8g of menthol, mix well, add water and stir for 40min, weigh polylysine Add 0.1 g of amino acid and stir for 10 minutes to obtain transparent microemulsion A. Observed under the transmission electronmicroscope as figure 1 .
[0070] (2) Weigh 3 g of sodium alginate and 0.5 g of chitosan, stir in water for 60 min, swell for 12 h, then mix, stir evenly, and adjust the pH to 6-8 to obtain transparent gel B.
[0071] (3) Mix liquid A and gel B, stir evenly, and get ready.
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Abstract
The invention discloses a multifunctional microemlusion gel preparation and a preparation process thereof, and belongs to the technical field of medicines. The preparation mainly comprises bulk pharmaceutical chemicals (such as non-steroidal anti-inflammatory drugs-diclofenacsodium, ibuprofen, indometacin, antifungal drugs-ornidazole, antiviral drugs-ganciclovir, hormone drugs-dexamethasone, local anesthesia drugs-lidocaine and irritants-menthol), a cationic polymer and a microemlusion, can further comprise gel or a thickener, and can be used for transdermal drug delivery and local drug delivery. The preparation process is simple, convenient, good in stability and pollution-free. Compared with existing cream and gel, the preparation has the advantages that a novel action mechanism is adopted, the accumulative penetration amount of unit area of drugs is remarkably increased, a certain slow-release effect is achieved, and the drug delivery frequency and the drug delivery amount can be reduced; a chemical penetration enhancer and a conventional preservative are not added, a certain bacterial inhibition effect is achieved, the skinirritation is avoided, and the use safety of the drugs is improved.
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