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Compound prepn for treating women's inflammation

A compound preparation, technology of gynecological inflammation, applied in the field of medicine

Inactive Publication Date: 2006-05-17
山东特瑞林医药科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, Ornidazole Effervescent Tablets, Butoconazole Nitrate Vaginal Cream, and Polycresol Sulfonaldehyde Suppositories are all on the market as single preparations, but there is no report of the three as compound preparations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1. Dosage form: vaginal suppository, the components are as follows:

[0047] Ornidazole 100g

[0048] Butoconazole Nitrate 400g

[0049] Polycresol 200g

[0050] Macrogol 4000 200g

[0051] Take polyethylene glycol 4000 and heat to melt, keep warm. Separately take ornidazole, butoconazole nitrate, and polycresol sulfonal, grind and mix them evenly, slowly add them into the above-mentioned melted matrix, stir evenly, keep warm, and pour into molds.

Embodiment 2

[0052] Embodiment 2. Dosage form: vaginal suppository, the components are as follows:

[0053] Ornidazole 600g

[0054] Butoconazole Nitrate 300g

[0055] Polycresol 250g

[0056] Polyoxyethylene 40 Stearate 100g

[0057] Glycerin gelatin 80g

[0058] The preparation method is the same as in Example 1.

Embodiment 3

[0059] Embodiment 3. Dosage form: vaginal effervescent tablet, the components are as follows:

[0060]Ornidazole 250g

[0061] Butoconazole Nitrate 50g

[0062] Polycresol 45g

[0063] Citric acid 110g

[0064] Sodium bicarbonate 130g

[0065] Get ornidazole, butoconazole nitrate, polycresol, and citric acid to pass through a 100-mesh sieve respectively, mix well, make a soft material with 5% (weight) polyvinylpyrrolidone (PVP) alcohol solution, and pass through a 14-mesh sieve Prepare wet granules, dry at 50°C to obtain dry granules 1);

[0066] Separately take sodium bicarbonate to pass through a 100-mesh sieve, use an appropriate amount of syrup to make soft materials, pass through a 12-mesh sieve to make wet granules, and dry at 50°C to obtain dry granules 2)

[0067] Then mix 1) and 2) the dry granules, granulate, add an appropriate amount of lubricant, mix well, and compress into tablets.

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PUM

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Abstract

The present invention is compound preparation for treating womení»s inflammation, and belongs to the field of medicine technology. Each 1000 application units of the compound preparation consists of ornidazole 100-1000 g, butoconazole nitrate 10-500 g and policresulen 50-300 g. The compound preparation may be prepared into different forms, including vaginal suppository, vaginal effervescent tablet, vaginal tablet, vaginal gel, etc. The compound preparation has the functions of resisting anaerobic bacteria, resisting protoplasm, resisting mildew and resisting aerobion, and may be used in treating various womení»s infectious diseases, such as bacterial vaginitis, mycotic vaginitis, protozoal vaginitis, non-specific vaginitis, mixed infectious vaginitis, pruritus vulvae, etc.

Description

(1) Technical field [0001] The invention relates to a compound preparation for treating gynecological inflammation, which belongs to the technical field of medicine. (2) Background technology [0002] According to the survey data of the World Health Organization, the population of women of childbearing age in my country is about 150 million to 200 million, of which about 41% of women suffer from gynecological inflammatory diseases to varying degrees, and the incidence rate of married women is as high as 70%. Anti-infective vaginal preparations play an important role in the treatment of gynecological inflammatory diseases and have always had a large market share. [0003] Products in the gynecological inflammation market are basically divided into two categories, external medicines and oral medicines. According to a survey on the pharmaceutical retail markets in five major cities of Beijing, Wuhan, Shanghai, Guangzhou and Shenzhen, external medicines accounted for 66.74% of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/795A61K31/4164A61P15/00
Inventor 肖广常张颖王淑娟闫海波
Owner 山东特瑞林医药科技发展有限公司
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