The invention relates to a method for industrial production of
butoconazole nitrate. The method comprises the following steps that firstly, 1-(2-
chlorine-4-(4-chlorphenyl)butyl)-1
hydrogen-
imidazole is mixed with 2,6-dichoribenzene
thiophenol,
anhydrous potassium carbonate and
acetone, a heating
reflux reaction is carried out,
anhydrous potassium carbonate is supplemented, the heating
reflux reaction is continued, cooling and filtering are carried out, and concentrate is obtained after filter liquor is concentrated; secondly, extract liquor containing
diethyl ether and water is added in the concentrate, after sufficient extraction is carried out, a water phase is discarded, and an organic phase is reserved; thirdly, concentrated
nitric acid is dripped into the obtained organic phase on ice bath and stirring conditions, and filtering is carried out when
sediment stops being generated; the filter liquor is discarded, a
filter cake is washed with
diethyl ether and
acetone in sequence, and the metric acid butoconazole is obtained after the
filter cake is dried. According to the method, conditions and parameters in the synthesizing process are comprehensively optimized, impurities likely to be introduced in the production process are effectively controlled, the production efficiency is improved, the purity and yield of products are increased, and the method is more suitable for large-scale industrial production.