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Antibacterial gynecology externally used pharmaceutical combination

A technology of externally used drugs and compositions, applied in the field of medicine, can solve problems such as stability problems and failure to achieve therapeutic effects, and achieve good stability, good therapeutic effects, and good antibacterial effects

Active Publication Date: 2008-09-24
万全万特制药(厦门)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although compound preparations have expanded antibacterial spectrum, many ingredients may cause stability problems
In addition, high-acid vaginitis is closely related to fungal vaginitis, and many fungal vaginitis is combined with high-acid vaginitis, which is why it is difficult to cure recurrent attacks with antifungal drugs alone.
Therefore, simply expanding the antibacterial spectrum and using multiple active ingredients in combination will not achieve good therapeutic effects.

Method used

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  • Antibacterial gynecology externally used pharmaceutical combination
  • Antibacterial gynecology externally used pharmaceutical combination
  • Antibacterial gynecology externally used pharmaceutical combination

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] This embodiment is in the form of a suppository.

[0016]

[0017] Preparation method: Weigh the prescribed amount of PEG-4000, PEG-6000, glycerin and water, heat and melt on a water bath; weigh the prescribed amount of butoconazole nitrate and sodium lactate and add them to the molten matrix, mix evenly; pour into the mold while hot Medium; let it cool, open the mold and take it out after it is completely solidified.

Embodiment 2

[0019] This embodiment is in the form of a vaginal tablet.

[0020]

[0021] Preparation:

[0022] Weigh the prescribed amount of butoconazole nitrate, sodium lactate, microcrystalline cellulose, mannitol and a part of crospovidone and mix evenly; add the aqueous solution of povidone to the mixture, and granulate. Blast drying at 50°C, granulation. Mix the two groups of dry granules, add the remaining portion of crospovidone and magnesium stearate, and mix well. Detect the particle content and press into tablets.

Embodiment 3

[0023] Example 3 This example exists in the form of vaginal effervescent tablets.

[0024]

[0025] Preparation:

[0026] Weigh the prescribed amount of butoconazole nitrate, mannitol and sodium bicarbonate and mix uniformly to obtain mixture 1; weigh the prescribed amount of microcrystalline cellulose and citric acid and mix uniformly to obtain mixture 2; add polyvinyl chloride to mixture 1 and 2 respectively Aqueous solution of ketone, granulated. Blast drying at 50°C, granulation. Mix the two groups of dry granules, add magnesium stearate, and mix well. Detect the particle content and press into tablets.

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PUM

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Abstract

The invention discloses an external gynecological drug compound which consists of an active ingredient butoconazole nitrate and other drug carriers acceptable in pharmacy. The external gynecological drug compound has the forms of suppositories, vaginal tablets and vaginal effervescent tablets and can be used for treating the fungal infection outside the vagina caused by mycotoruloides.

Description

technical field [0001] The invention relates to an antibacterial pharmaceutical composition for external use in gynecology, which belongs to the technical field of medicine. Background technique [0002] Fungal vaginitis is one of the three major vaginal common diseases in women (the remaining two are bacterial vaginosis and trichomonal vaginitis), and its incidence rate is high, and it is difficult to cure it. Butoconazole nitrate is an imidazole antifungal drug, its antibacterial effect on Candida albicans is equal to or better than other imidazole derivatives such as clotrimazole, miconazole and nystatin. Its cure rate is 80% and 95% in 3 days and 8 days of clinical application, which is obviously better than clotrimazole. The course of treatment is short, the side effects are small, and the tolerance is good. [0003] At present, KV Pharmaceutical Company of the United States has listed butoconazole nitrate cream, the product name is GYNAZOLE-1 . The medicine of the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4164A61K9/02A61K9/20A61K9/46A61K47/02A61K47/12A61K47/38A61P31/02A61P15/02
Inventor 袁筝
Owner 万全万特制药(厦门)有限公司
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