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Preparation process of butoconazole nitrate vagina plug and use thereof

A technology of butoconazole nitrate and vaginal suppository, which is applied in the new field of medicine, and achieves the effect of simple method and good stability

Inactive Publication Date: 2009-06-17
BEIJING HOPE HUGE PHARM SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] 1. Pharmacology and Toxicology

Method used

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  • Preparation process of butoconazole nitrate vagina plug and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1: specification 1000 pieces

[0044] prescription:

[0045] Butoconazole Nitrate 100g

[0046] Polyethylene glycol-4000 571g

[0047] Polyethylene glycol-1000 342.6g

[0048] Mixed fatty acid glycerides 171.3g

[0049] Propylene glycol 57.1g

[0050] Preparation method:

[0051] ① Pass butoconazole nitrate through a 100-mesh sieve.

[0052] ② Melt the prescribed amount of polyethylene glycol-1000, polyethylene glycol-4000, mixed fatty acid glycerides, and propylene glycol in a water bath at about 65°C, and stir evenly.

[0053] ④ Add the prescribed amount of butoconazole nitrate and stir well.

[0054] ⑤ Pour into the cooled and coated model of liquid paraffin in the molten state.

[0055] ⑥Let it cool until it is completely solidified.

[0056] ⑦Finished product inspection and packaging.

Embodiment 2

[0057] Embodiment 2: specification 10000 pieces

[0058] prescription:

[0059] Butoconazole Nitrate 1000g

[0060] Polyethylene glycol-4000 5710g

[0061] Polyethylene Glycol-1000 3426g

[0062] Mixed fatty acid glycerides 1713g

[0063] Propylene glycol 571g

[0064] Preparation method:

[0065] ① Pass butoconazole nitrate through a 100-mesh sieve.

[0066] ② Melt the prescribed amount of polyethylene glycol-1000, polyethylene glycol-4000, mixed fatty acid glycerides, and propylene glycol in a water bath at about 65°C, and stir evenly.

[0067] ④ Add the prescribed amount of butoconazole nitrate and stir well.

[0068] ⑤ Pour into the cooled and coated model of liquid paraffin in the molten state.

[0069] ⑥Let it cool until it is completely solidified.

[0070] ⑦Finished product inspection and packaging.

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PUM

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Abstract

The invention discloses a preparation method for vaginal suppository having butoconazole nitrate and application therefor. The invention belongs to the field of new technology of drug, relating to a suppository of butoconazole nitrate, pharmaceutical preparation for treating candida vaginitis and preparation method thereof.

Description

technical field [0001] The invention belongs to the field of new medicine technology, and relates to a new dosage form of butoconazole nitrate, a pharmaceutical preparation for treating candida vaginitis and a preparation method thereof, specifically a preparation method of butoconazole nitrate vaginal suppository and its application. Background technique [0002] According to the incomplete statistics of the World Health Organization, the incidence rate of various gynecological diseases among women is more than 65%. According to the survey of relevant data in our country, gynecological diseases tend to be younger and become the "killer" that threatens the health of women in our country. The incidence of gynecological diseases in women of childbearing age is more than 70%. Almost 100% of women have suffered from different degrees of vaginitis in their lifetime, and more than 5% of them have seriously affected their normal work and life due to their illness. At the same time...

Claims

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Application Information

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IPC IPC(8): A61K31/4164A61K9/02A61P15/02A61P31/10
Inventor 王翰斌武广俣闫艳立
Owner BEIJING HOPE HUGE PHARM SCI
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