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Preparation method of butoconazole

A technology of butconazole and chlorobenzyl chloride, applied in the field of preparation of butoconazole, can solve the problems of high production cost, complicated manufacturing and the like, and achieve the effects of low production cost, simple manufacturing and high infection efficiency

Inactive Publication Date: 2015-07-01
储海燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the current production of butoconazole, the manufacture is complicated and the production cost is high

Method used

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Embodiment Construction

[0006] Now in conjunction with the present invention for further detailed description.

[0007] The preparation method of a kind of butoconazole of the present invention, concrete steps are as follows: take p-chlorobenzyl chloride as raw material, after being converted into Grignard reagent, react with chloropropylene oxide to obtain 1-chloro-4-p-chlorobenzene Base butanol-2, introduce imidazole group, and then convert the hydroxyl group into chlorine, then introduce 2,6-dichlorothiophenol to get butoconazole, which can be acidified with nitric acid to get butoconazole nitrate.

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Abstract

The invention relates to a preparation method of butoconazole. The method comprises the following specific steps: converting a raw material p-chlorobenzyl chloride into a Grignard reagent, reacting with chloro epoxypropane to obtain 1-4-chloro-p-chlorophenyl butanol-2, introducing imidazole, converting the hydroxyl into chlorine, introducing 2,6-dichloro thiophenol to obtain butoconazole, and acidifying with nitric acid to obtain butoconazole nitrate. The preparation method of butoconazole is simple in manufacture and low in production cost, and the butoconazole is an antifungal drug highly effective in the infection of Candida albicans and Candida albicans.

Description

technical field [0001] The invention relates to the field of medicine production, in particular to a preparation method of butoconazole. Background technique [0002] Butoconazole is an imidazole antifungal drug, mainly used for the treatment of vaginal candidiasis, butoconazole is white to off-white crystalline powder, slightly soluble in methanol, slightly soluble in chloroform, dichloromethane, acetone, ethanol, Very slightly soluble in ethyl acetate, almost insoluble in water, melting point is about 159°. Due to the current production of butoconazole, the manufacture is complicated and the production cost is high. Contents of the invention [0003] The technical problem to be solved by the present invention is: in order to overcome the above-mentioned problems, a preparation method of butoconazole is provided. [0004] The technical scheme that the present invention adopts to solve its technical problem is: a kind of preparation method of butoconazole, concrete steps...

Claims

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Application Information

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IPC IPC(8): C07D233/60
CPCC07D233/60
Inventor 储海燕
Owner 储海燕
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