Individual method for fast obtaining tumor specific antibodies

A tumor-specific, antibody technology, applied in the direction of antibodies, anti-tumor drugs, anti-animal/human immunoglobulins, etc., can solve the difficulties of multiple specific antibodies, and achieve the effect of facilitating research and improving efficiency

Pending Publication Date: 2018-05-29
裴新辉
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, as mentioned earlier, it is very difficult to obtain antibodie

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  • Individual method for fast obtaining tumor specific antibodies
  • Individual method for fast obtaining tumor specific antibodies
  • Individual method for fast obtaining tumor specific antibodies

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Embodiment Construction

[0044] The present invention is described in detail below in conjunction with embodiment. In order to make the object, technical solution and advantages of the present invention clearer and clearer, the present invention will be described in further detail below with reference to the accompanying drawings and examples, but the present invention is not limited to these examples. Unless otherwise specified, the raw materials and catalysts in the examples of the present invention were purchased through commercial channels.

[0045] Obtaining specific monoclonal antibodies against cancer cells has always been a key factor in the immunotherapy of many tumors. Unfortunately, so far, there is no efficient screening method for this antibody. The invention provides a method for efficiently obtaining monoclonal antibodies against cancer cells. The core design idea of ​​the method of the present invention is to use anti-corresponding normal cell antibodies to directly remove the antige...

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Abstract

The invention discloses an individual method for fast obtaining tumor specific antibodies. The method comprises the following steps of directly removing cancer cell or cancerous tissue and normal cellor normal tissue sharing antigens by normal cell or normal tissue antibodies with corresponding antibody phases in the body. The method does not perform large-scale scanning on the antigens in vitro.By using the method, 11 kinds of anti-HepG2 monoclonal antibodies are obtained. The monoclonal antibodies have the specific recognition on HepG2, and do not recognize or basically do not recognize HHcell. Meanwhile, compared with cancer cells with other tissue resources, the monoclonal antibodies have specific recognition on HePG2.

Description

technical field [0001] The invention relates to the technical field of antigen-antibody screening in molecular biology, in particular to a method for individualized and rapid acquisition of tumor-specific antibodies. Background technique [0002] In the current biological treatment of tumors, immunotherapy has always been a hot spot in research and application. Generally speaking, there are currently two main methods. One is based on cellular immunity, that is, allowing killer T cells to recognize and kill cancer cells; the other is based on humoral immunity, that is, obtaining tumor-specific antibodies, and then activating the complement pathway through antibodies or by coupling to antibodies Drugs that specifically kill cancer cells. But no matter what kind of immunotherapy, getting the immune system to recognize cancer cells is the most critical step. [0003] But cancer cells are a kind of malignant hyperplasia cells that escape the immune surveillance of the body. Th...

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Application Information

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IPC IPC(8): C07K16/30A61K39/395A61P35/00
CPCA61K2039/505C07K16/30
Inventor 裴新辉
Owner 裴新辉
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