Biological enzyme-carrying calcium phosphate bone cement for preventing and treating bone infection and preparation method thereof

Abstract

The invention belongs to the technical field of medicaments and particularly relates to a biological enzyme-carrying calcium phosphate bone cement with a controlled release effect and a preparation method thereof. The preparation disclosed by the invention comprises the following components in percentage by weight: 25 to 90 percent of calcium phosphate bone cement substrate, 0.001 to 50 percent of biological enzyme composite and 5 to 50 percent of curing liquid. When the biological enzyme-carrying calcium phosphate bone cement preparation is implanted, the biological enzyme with an antibacterial effect is released suddenly and then is stably released, so the biological enzyme-carrying calcium phosphate bone cement has the effect of filling and repairing bone defect as well as the effects of preventing and treating bacterial infection, and can be used for treating chronic osteomyelitis, preventing implanted part infection and preventing relapse after a bone tumor is removed.

Description

technical field

[0001] The invention belongs to the field of biological preparations, in particular to an enzyme-loaded calcium phosphate bone cement with controlled release and a preparation method thereof. Background technique

[0002] Bone defect caused by trauma, tumor and other reasons is a difficult problem in clinical treatment. The aseptic state of the implant site is the premise and key to the success of bone grafting. Clinical studies have shown that if the site to be implanted is infected, the treatment effect will not be good, especially for large and medium-sized orthopedic operations. Once infection occurs, the patient's mortality rate will increase, the hospitalization time will be prolonged, and the hospitalization cost will increase significantly. Due to the irrational use of antibiotics, drug-resistant bacteria are gradually increasing in clinical practice. In recent years, the research focus of new antibacterial drugs at home and abroad has begun to turn...