Filling material for bone defect part caused after giant bone cell tumor removal operation and preparation method of filling material

A technology for giant cell tumor of bone and bone defect, which is applied in the field of medical engineering to achieve the effects of reducing corrosion rate, good biocompatibility, and inhibiting vitality

Inactive Publication Date: 2018-06-08
GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the rapid degradation rate of magnesium in the physiological environment is a major factor limiting its rapid clinical application.

Method used

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  • Filling material for bone defect part caused after giant bone cell tumor removal operation and preparation method of filling material
  • Filling material for bone defect part caused after giant bone cell tumor removal operation and preparation method of filling material
  • Filling material for bone defect part caused after giant bone cell tumor removal operation and preparation method of filling material

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The magnesium-strontium alloy (Mg-1.5wt.%Sr) substrate was cut to a suitable size, polished on No. 220 sandpaper until there was no oxide layer, and then successively polished on 800-mesh alumina water-resistant sandpaper and 2000-mesh SiC water sandpaper. The polished magnesium alloy substrate was ultrasonically cleaned in acetone and alcohol for 30 minutes in sequence, washed with distilled water and dried for later use. Soak the sample in 0.1M potassium fluoride solution for 24 hours for fluorination pretreatment, then soak the pretreated magnesium-strontium alloy in a solution containing 60g / L NaNO 3 ,15g / LCa(H 2 PO 4 ) 2 ·H 2 O and 20mL / LH 2 o 2 In the phosphate mixture for 24 hours, a calcium-phosphorus coating is formed on the surface. Soak the magnesium-strontium alloy substrate with calcium-phosphorus coating in 5mL of 10 -2 In the μM zoledronic acid solution, incubate at 37°C for 24 hours to form a zoledronic acid coating on the surface of the magnesium...

Embodiment 2

[0033] Cut the magnesium-strontium alloy (Mg-1.5wt.%Sr) substrate to a suitable size, polish it on No. 220 sandpaper until there is no oxide layer, and then successively polish it on 800 mesh alumina water-resistant sandpaper and 2000 mesh SiC water sandpaper. The polished magnesium alloy substrate was ultrasonically cleaned in acetone and alcohol for 30 minutes in sequence, washed with distilled water and dried for later use. Soak the sample in 0.1M potassium fluoride solution for 24 hours for fluorination pretreatment, then soak the pretreated magnesium strontium alloy in 60g / L NaNO 3 ,15g / L Ca(H 2 PO 4 ) 2 ·H 2 O and 20mL / L H 2 o 2 After 24 hours in the middle, a calcium phosphorus coating is formed on the surface. Soak calcium-phosphorus-coated magnesium-strontium alloy in 5mL of 10 -2 In the μM sodium pamidronate solution, incubate at 37°C for 24 hours, and form a bisphosphonate coating on the surface of the magnesium alloy substrate through the chelation of sodium...

Embodiment 3

[0035] Cut the magnesium-strontium alloy (Mg-1.5wt.%Sr) substrate to a suitable size, polish it on No. 220 sandpaper until there is no oxide layer, and then successively polish it on 800 mesh alumina water-resistant sandpaper and 2000 mesh SiC water sandpaper. The polished magnesium alloy substrate was ultrasonically cleaned in acetone and alcohol for 30 minutes in sequence, washed with distilled water and dried for later use. Soak the sample in 0.1M potassium fluoride solution for 24 hours for fluorination pretreatment, then soak the pretreated magnesium strontium alloy in 60g / L NaNO 3 ,15g / L Ca(H 2 PO 4 ) 2 ·H 2 O and 20mL / L H 2 o 2 After 24 hours in the middle, a calcium phosphorus coating is formed on the surface. Soak calcium-phosphorus-coated magnesium-strontium alloy in 5mL of 10 -2 Incubate in μM sodium allenphosphate solution at 37°C for 24 hours to form a bisphosphonate coating on the surface of the magnesium alloy substrate through the chelation of sodium all...

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Abstract

The invention discloses a filling material for a bone defect part caused after the giant bone cell tumor removal operation. The filling material comprises a magnesium alloy matrix and a calcium phosphate coating arranged on the surface of the magnesium alloy matrix, and diphosphonate is loaded on the calcium phosphate coating. The invention further discloses a preparation method of the filling material for the bone defect part caused after the giant bone cell tumor removal operation. The filling material for the bone defect part caused after the giant bone cell tumor removal operation takes amagnesium alloy material as a matrix, the calcium phosphate coating and a diphosphonate double-film layer are arranged on the matrix, the materials are taken as a filling material for a tumor cavity left after the giant bone cell tumor removal operation, the purpose of releasing the drug to the nidus is fulfilled, the effects that the diphosphonate drug inhibits the bone destruction of the tumor defect part and the bone absorption is prevented are achieved, meanwhile, the effect that the degradable magnesium alloy repairs the bone defect is achieved, the reconstruction of the bone defect caused after the giant bone cell tumor removal operation is realized, and the relapse rate of the tumor is reduced.

Description

technical field [0001] The invention relates to the field of medical engineering, in particular to a filler for a bone defect after excavation of a giant cell tumor of bone and a preparation method thereof. Background technique [0002] Giant cell tumor of bone is one of the most common primary bone tumors, accounting for about 20% of primary bone tumors. Its clinical manifestation is active pain, and those with severe cortical bone destruction are prone to pathological fractures. At present, it is believed that the tumor cells of giant cell tumor of bone are not sensitive to systemic chemotherapy, and the size of the tumor can be controlled before operation only when metastasis occurs. The general treatment for giant cell tumor of bone is curettage and bone grafting in the lesion capsule, which can preserve the joint function relatively well. Bone cement is currently used as a bone defect filler after curettage of giant cell tumor of bone. However, the monomer components r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/04A61L27/32A61L27/54A61L27/58
CPCA61L27/047A61L27/32A61L27/54A61L27/58A61L2300/112A61L2300/21A61L2300/416A61L2300/608A61L2420/08A61L2430/02
Inventor 李梅张余夏虹万鹏
Owner GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND
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