84 results about "Curcumenol" patented technology

The invention provides a curcumenol solid lipid nanoparticle and its preparation method, which comprises curcumenol 1 part, phospholipids 3-10 parts, grease material 5-100 parts, surface active agent 10-200 parts and excipient 10-400 parts.

The invention belongs to the technical field of medical technology, and relates to novel compounds, which are shown in a general formula (I) and have the activity of resisting influenza A(H1N1) virus, wherein R1 and R2 are defined as in the specification. The invention also relates to application and a preparation method of the compounds, and clinically acceptable medicines for treating infectious diseases of influenza A(H1N1) virus, which are prepared by combining the compounds with pharmaceutically acceptable carriers. The structure of formula (I) is shown in the specification.

The invention provides a curcuma total sesquiterpene and tri-sesquiterpene monomer as well as a preparation method and application on an aspect of resisting diabetes. A curcuma plant is taken as a raw material and is subjected to supercritical CO2 extraction or organic solvent extraction, then, low-polarity organic solvent is used for extraction to obtain a low-polarity total sesquiterpene extractive, and the low-polarity total sesquiterpene extractive is subjected to further chromatographic separation to obtain three types of sesquiterpene pure products of curcumenol, curdione and zedoary epoxy ketone. Activity research indicates that the total sesquiterpene, the curcumenol, the curdione and the zedoary epoxy ketone can be used for effectively increasing the consumption of glucose of HepG2 cells so as to obtain antidiabetic activity, and the total sesquiterpene, the curcumenol, the curdione and the zedoary epoxy ketone can be used for preparing antidiabetic medicines, antidiabetic health care food, functional foods and the like. The invention researches and develops new application of the diabetes resistance of the sesquiterpene in curcuma plants, the medicine function range of the curcuma plant is expanded, a basis is provided for carrying out popularization, utilization and deep processing on traditional Chinese medicinal materials, and a new application direction is provided.

The invention discloses a process for extracting curcumenol by a molecular distillation method. The process comprises the following steps of: adding zedoary oil into a feeding unit; firstly carrying out normal-temperature degassing under vacuum degree, and then opening condensed water and an oil-bath heater; after the temperature is stable, starting scraping-film stirring; then dripping the zedoary oil into a distiller; after the dripping is finished, collecting direct condensation fractions, external condensation fractions, unevaporated residual parts and degassed light components and losing; after the unevaporated residual parts are placed for one day, precipitating a great amount of crystals, using petroleum ether to carry out milliliter pulping, filtering, and drying to obtain white crystal; using alcohol with the mass concentration being 95% to recrystallize the crystal, and obtaining the curcumenol crystal with the gas chromatography GC being larger than 99%. The process disclosed by the invention has the advantages that according to the molecular distillation principle, the zedoary oil is treated by molecular distillation, the liquid part is condensed into liquid on an internal condenser by short-process distillation, then the discharged material is discharged, the zedoary oil can be rapidly separated from the curcumenol, and by combination with the recrystallizing technology, the curcumenol with high purity can be obtained.

The invention discloses a new curcumenol glycoside compound and making method and application to treat cancer, bacteria and virus, which is characterized by the following: decorating curcumenol through glycoside; possessing excellent tumour resistant and virus resistant activity.

The invention relates to a pharmaceutical composition for treating liver cancer. The pharmaceutical composition is prepared from raw materials of peimine, curcumenol, cucurbitacin and sweroside in certain proportion; and the pharmaceutical composition can be prepared into various dosage forms according to the conventional preparation process. The pharmaceutical composition provided by the invention has great significance to the preparation of medicaments for the treatment of liver cancer.

The invention discloses a method for measuring volatile components of medicinal material radix curcumae by QAMS (Quantitative Analysis of Multi-components by Single-marker). The method comprises the following steps: (1) preparation of a test liquor: taking the medicinal material radix curcumae, extracting a volatile oil by a steam distillation method, passing through a C8 or C18 stationary phase column, abandoning effluent, eluting with methanol, and collecting a methanol eluent for fixing a volume and being used as the test solution; (2) preparation of a reference liquor: taking curdione, dissolving with methanol, fixing the volume and using as the reference solution; (3) taking the test solution and the reference solution, respectively injecting into a high performance liquid chromatograph to obtain a chromatogram; and (4) first, using the reference product curdione as a reference, using a one-point external standard method or a working curve method to calculate the content of curdione in the test solution, then using a correction factor to calculate contents of curcumene ketone, curcumenol, curzerenone and germacrone. The method realizes simultaneous measurement of five sesquiterpenoids, reduces production cost, improves production efficiency and economic benefits, is fast and accurate, and can more comprehensively cover the quality of the medicinal materials.

The invention belongs to the technical field of medicine, and provides a medicine compound for curing cervical diseases. The medicine compound contains germacrone, furanodiene, curdione, beta-elemene, curcumenol, curzerene and borneol. The medicine compound has the advantages of clear composition and mass controllability; in the medicine compound, the weight parts of the curzerene and curcumenol are controlled, so the irritation of the medicine is reduced; and the medicine compound provided by the invention can be used for preparing suppositories, ointment, capsules, effervescent tablets, gels, lotions, membranes or foaming agents, achieves a good curative effect on HR-HPV (high-risk human papillomavirus) and / or LR-HPV (low-risk human papillomavirus) and the cervical diseases, and is suitable for clinical extensive use.