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Rapid center control testing method of Xingnaojing injection

A technology of Xingnaojing injection and detection method, which is applied in the field of near-infrared detection, can solve problems such as no relevant reports, and achieve the effects of stable product quality and improved quality control level.

Active Publication Date: 2013-02-13
WUXI JIMIN KEXIN SHANHE PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented method allows for quick detection of different qualities that affect how well an injected medicine works when it comes out from its container during production or storage time before use by measuring absorption spectrometry data on specific areas within this solution's composition. By analyzing these measurements with other methods like infrared spectroscopy, we can quickly determine which parts are better than others based on their properties such as cure activity, content, purity, etc., ensuring consistently high levels of drug being used effectively without any issues associated therewith.

Problems solved by technology

This patented technical problem addressed by this patent describes how quickly and accurately determine important indicator values during the manufacturing processes involved in producing Xingnai Anemia tablets that contain various ingredients like curanins, mangosols, carboxylic acids, therapeutene, vanilla extractives, cuminascent powder, tincters, rosemary bark oil, licorice root, maslin liquid, nisebaccharides, amygnetoidones, pigments, mineral salves, yellow glue, safflower, charcoils, reservoir liquids, syringe plungings, dilute ethylcholine solution, lycophoresis machines, centrifuge techniques, solvent extraction methodologies, and other conventional analyte gas absorption/distilling technique.

Method used

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  • Rapid center control testing method of Xingnaojing injection
  • Rapid center control testing method of Xingnaojing injection
  • Rapid center control testing method of Xingnaojing injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] (1) Distillate sample collection

[0060] Collection of distillate samples during the primary distillation of different batches of medicinal materials

[0061] One distillation process: turmeric and gardenia medicinal materials, add 25 times the amount of distilled water for distillation. After reaching the distillation temperature (keep warm, about one hour after the start of temperature rise), start to collect distillate samples, and the time interval of sample collection is 1 hour. The samples taken were used for the determination of curdione, curcumol, gemaconone and the total peak area of ​​the liquid phase respectively. The distillation extraction experiment of 6 batches of turmeric and gardenia medicinal materials was repeated, and samples were taken in the same way for each batch of experiments, and a total of 120 primary distillate samples were obtained.

[0062] (2) Determination of key indicators

[0063] Sample pretreatment method: Take 10ml of the distil...

Embodiment 2

[0078] According to the method of Example 1, the difference lies in the establishment of a rapid analysis model for each key index in the secondary distillation process.

[0079] (1) Collect distillate samples from different batches of medicinal materials during secondary distillation

[0080] Secondary distillation process: Take the primary distillate and add musk and appropriate amount of distilled water for distillation. After reaching the distillation temperature (keep warm, about one hour after the start of temperature rise), start to collect distillate samples, and the time interval of sample collection is 1 hour. The samples taken were used for the determination of curdione, curcumol, gemacone, muscone and the total peak area of ​​the liquid phase respectively. Six batches of secondary distillation experiments were repeated, and samples were taken in the same way for each batch of experiments. A total of 120 secondary distillation samples were obtained for establishing...

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Abstract

The invention relates to a rapid center control testing method of Xingnaojing injection. The rapid center control testing method comprises the following steps of: (1) acquiring samples of primary distillate and secondary distillate in the preparation process of the Xingnaojing injection of different batches; (2) testing the areas of the curcuma zedoary diketone, the curcumenol and the Germacrone in the distillate samples and the total liquid phase peak areas by using a liquid chromatographic method, and testing the muscone peak areas in the distillate samples by using a gas chromatographic method; (3) acquiring near infrared spectrum data of the distillate samples; (4) constructing a model; and (5) testing the content of the curcuma zedoary diketone, the curcumenol, the Germacrone and the muscone in unknown distillate samples.

Description

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Claims

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Application Information

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Owner WUXI JIMIN KEXIN SHANHE PHARMA
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