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Curcumenol self-emulsifying capsule and preparation method thereof

A curcumol and self-emulsifying technology, applied in the field of medicine, can solve the problems of incomplete absorption and low bioavailability, and achieve the effects of convenient administration, high bioavailability, and favorable gastrointestinal absorption.

Inactive Publication Date: 2007-02-28
高保安
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, it can still directly act on other viruses such as rheumatism virus and varicella virus, and may also have inhibitory effects on parainfluenza virus, paramyxovirus, Coxsackie virus, etc.
[0005] This shows that curcumol has broad prospects in clinical application, but because it is almost insoluble in water, the solubility in water is only 0.3% (Deng Rong, Chen Jimin, Yao Chongshun etc., Liaoning Medicine and Clinical, 2001, 4 (1 ): 37.), which is a solid drug that is insoluble in water, so it is made into oral dosage forms such as ordinary tablets, dripping pills, and solid capsules, which will lead to low bioavailability and incomplete absorption.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Weigh 420g of glyceryl caprylate, add 185g of curcumol, fully dissolve it by ultrasonic at 25°C, then add 395g of polyoxyethylene (40) castor oil, stir at 25°C to make it uniform and transparent The solution is prepared into soft capsules with a specification of 1.5g of content per capsule, that is, 277.5mg of curcumol per capsule, using a compression method and an automatic rotary encapsulation machine. As determined by a Zetasizer Nano S nanometer particle size analyzer, the self-emulsifying soft capsule preparation has an average self-emulsifying particle size of 60nm and a distribution range of 50nm to 80nm under the condition of gentle stirring in water at 37°C in vitro.

Embodiment 2

[0028] Weigh 540g of soybean oil, mix well, add 150g of curcumol, and dissolve it fully by ultrasonic at 45°C, then add 263g of Simplo high-efficiency solubilizer TCS-100P, 47g of polyoxyethylene (60) hydrogenated castor oil, Stir at 50°C to make it a uniform and transparent solution, fill and seal, and prepare hard capsules each containing 1.2 g of content, that is, each containing 180 mg of curcumol. As determined by a Zetasizer Nano S nanometer particle size analyzer, the self-emulsifying hard capsule preparation has an average self-emulsifying particle size of 80nm and a distribution range of 70nm to 100nm under the condition of gentle stirring in water at 37°C in vitro.

Embodiment 3

[0030]Weigh 377g of safflower seed oil, 98g of sesame oil, 73g of corn oil, 70g of linseed oil, and 140g of seabuckthorn oil, mix well, add 100g of curcumol, fully dissolve it by stirring at 75°C, then add 25g of lecithin, Polysorbate 65 42g, Simpro high-efficiency solubilizer SF-410 57g, and Simpro high-efficiency solubilizer SF-400 18g were stirred at 75°C to make a uniform and transparent solution. The capsule machine is prepared into soft capsules with a specification of 1 g of content per capsule, that is, 100 mg of curcumol per capsule. Measured by a ZetasizerNano S-type nanoparticle size analyzer, the self-emulsifying soft capsule preparation has an average self-emulsifying particle size of 200nm and a distribution range of 190nm to 220nm under the condition of gentle stirring in water at 37°C in vitro.

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Abstract

Disclosed is a curcumenol self-emulsifying capsule preparation and its preparing process, wherein the capsule preparation is prepared from curcumenol, oil and emulsifying agent through dissolving curcumenol into oil through agitating or ultrasonic sound at 25-85 deg C, charging emulsifying agent, stirring homogeneously and encapsulating. The preparation can be made into soft capsules or hard capsules having better stability, higher biological availability, easier body absorption, improved curative effect and easier administration.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a curcumol self-emulsifying capsule preparation with antitumor, antibacterial, antiviral, antimutagenic and hepatoprotective therapeutic effects and a preparation method thereof. Background technique [0002] Curcumol, also known as curcumol and curcumol, belongs to terpenoids and is an important component of zedoary volatile oil. Molecular formula is C 15 h 24 o 2 , molecular weight 236.34. Since the 1970s, it has been used in the treatment of cervical cancer and has achieved certain curative effects. In recent years, pharmacists have conducted extensive research on curcumol, which shows that curcumol has pharmacological effects such as anti-tumor, anti-early pregnancy, anti-virus, anti-mutation, liver protection, blood circulation and blood stasis, among which curcumol has the role of anti-tumor attracted the attention of many researchers. [0003] According to reports (...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61K9/107A61K9/48A61K47/44A61P35/00A61P31/12A61P15/04
Inventor 高保安
Owner 高保安
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