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Medical compound containing borneol

A composition and drug technology, applied in the field of medicine, can solve the problems of variable content of active ingredients, volatile, affecting curative effect, etc., and achieve the effects of good therapeutic effect, controllable quality and clear ingredients.

Active Publication Date: 2013-01-02
HAINAN BIKAI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the past ten years, traditional Chinese medicine represented by Baofukang Suppository (the main components are zedoary oil and borneol) has been widely used in the treatment of female reproductive tract HPV infection, and has achieved certain curative effect, but the zedoary oil used has complex components. , the content of active ingredients is variable and volatile, which obviously affects the curative effect; therefore, it is urgent to develop a pharmaceutical composition with clear ingredients and stable content to prevent and treat HPV infection and the benign or malignant lesions induced by it, especially for the HR of cervical cancer. -HPV infection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0167] Prescription: Gemacerone 14.9g, furadienes 39g, curdione 24g, β-elemene 9.1g, curcumol 0.5g, curcumene 0.5g, borneol 75g (the content of borneol in borneol is 83.9%).

[0168] Dosage form: suppository.

[0169] Preparation method: mix the prescribed amount of gemmacone, furadienes, curdione, β-elemene, curcumol, curcumene with 71g of polysorbate 80, dissolve 75g of borneol with an appropriate amount of ethanol, and mix with the above solution Mix well.

[0170] The polyoxyethylene stearate 1533g of prescription quantity is put on the water bath and is heated and melted, adds above-mentioned medicinal liquid, stirs, filling, makes 1000 suppositories, each 1.74g.

Embodiment 2～8

[0172] Prepare the suppository according to the following prescription, the preparation method is the same as in Example 1, (the content of borneol in the borneol is 60.5%).

[0173] Example

Embodiment 9

[0175] Prescription: Gemacerone 6.5g, Furandiene 32g, Curdione 21g, β-Elemene 8.5g, Curcumol 0.45g, Borneolum 35g (the content of Borneo in Borneolum is 70.3%).

[0176] Dosage form: effervescent tablet.

[0177] Preparation:

[0178] 1) Take β-cyclodextrin, add appropriate amount of water according to 25ml / g, stir to make it fully dissolved, and heat if necessary to obtain β-cyclodextrin solution; ene, curcumol, borneol 35g, diluted with absolute ethanol, slowly added to the β-cyclodextrin solution, continued to stir until a homogeneous phase was formed, placed in the refrigerator overnight, filtered with suction, washed 3 times with a small amount of petroleum ether, frozen, A white powder was obtained.

[0179] 2) Mix the above-mentioned white powder with 35g of borneol, 150g of citric acid and 160g of lactose; take another 120g of sodium bicarbonate and 160g of lactose, mix them evenly, and use 5% PVP absolute ethanol solution as a binder to granulate, at 50°C Dry, gran...

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Abstract

The invention belongs to the technical field of medicines, and provides a medical compound containing borneol. The medical compound contains germacrone, furanodiene, curdione, beta-elemene, curcumenol, curzerene and borneol. The medical compound containing borneol is definite in ingredients and controllable in quality; the content of camphol in the borneol is controlled, so that the blood concentration and the mucosa absorbing rate of the medical compound are improved; the medical compound provided by the invention can be used for preparing suppository, ointment, capsules, effervescent tablets, gels, lotions, film agents or foaming agents; and the medical compound provided by the invention can well treat HR-HPV (high-risk human papilloma virus) and / or LR-HPV (low-risk human papilloma virus), cervical disease and the like, and is suitable for wide clinical application.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a pharmaceutical composition containing gemmacone, furadienes, curdione, β-elemene, curcumol, curcumene and borneol. Background technique [0002] Human papillomavirus (HPV) is a kind of papillomavacuolating virus A belonging to Papovaviridae. It is a spherical DNA virus that can cause squamous epithelial proliferation of human skin and mucous membranes. At present, more than 130 kinds have been isolated, and different subtypes cause different clinical manifestations and invade different tissue parts. According to the classification of cancer, it can be divided into low-risk HPV and high-risk HPV. [0003] HR-HPV mainly includes 13 subtypes, which are closely related to the occurrence of cervical cancer and cervical squamous neoplasia (CIN). Persistent infection of the cervix with HR-HPV can develop into cervical cancer within 8 to 10 years, and "cervical cancer" ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/35A61K31/343A61K31/122A61K31/045A61K31/015A61P31/20A61P15/02A61P15/00A61P35/00
Inventor 陈容徐扬冯仲异史朝辉
Owner HAINAN BIKAI PHARM CO LTD
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