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Curcumenol solid lipid nano-particle and its preparation method

A technology of solid lipid nanoparticles and curcumitol, which is applied in the directions of liposome delivery, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve problems such as solid lipid nanoparticles without physical and chemical properties, and improve bioavailability. , the effect of reducing the dosage of the drug and improving the therapeutic index

Inactive Publication Date: 2006-05-03
NANJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report of curcumol solid lipid nanoparticles in the prior art, and there is no report of solid lipid nanoparticles with similar or similar physical and chemical properties to it

Method used

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  • Curcumenol solid lipid nano-particle and its preparation method
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Dissolve 10mg of curcumol and 50mg of stearic acid in 8ml of acetone, dissolve 30mg of soybean lecithin in 2ml of ethanol, and mix the two parts to form the organic phase. 100 mg of Poloxamer 188 was dissolved in 40 ml of distilled water to constitute the aqueous phase. Heat the organic phase and the water phase to 75°C respectively, and slowly inject the organic phase into the water phase with a No. 6 needle under the stirring condition of 1500 rpm to form a translucent system; evaporate the translucent system under reduced pressure with a rotary evaporator The organic solvent was removed and concentrated to 2 / 5 volume. The concentrated system was quickly mixed in the water phase at 0°C, stirred and cooled for 2 hours, and then processed by a high-pressure homogenizer at a working pressure of 800 Bar in an ice bath for 3 cycles to obtain a solid lipid nanoparticle suspension. Add 100 mg of excipient mannitol to the obtained nanoparticle suspension to dissolve, filter ...

Embodiment 2

[0053] Dissolve 10mg of curcumol, 900mg of glyceryl monostearate in 8ml of acetone, 800mg of dipalmitoylphosphatidylcholine in 2ml of ethanol, and mix the two parts to form the organic phase. 2000 mg of Poloxamer 188 was dissolved in 40 ml of distilled water to form the aqueous phase. The preparation process is the same as in Example 1, except that the high-pressure homogeneous working pressure is changed to 1000 Bar, the translucent system is concentrated to the original 1 / 2 volume, the amount of excipient trehalose added to the suspension is 2 g, and the spray-drying method is used to dry.

[0054] Detection: the average particle diameter of curcumol solid lipid nanoparticles is 216.2nm, and the encapsulation efficiency is 72.56%.

Embodiment 3

[0056] Dissolve 10mg curcumol, 100mg triolein in 8ml acetone, 100mg soybean lecithin in 2ml ethanol, and mix the two parts to form the organic phase. 200 mg of Poloxamer 188 was dissolved in 40 ml of distilled water to form the aqueous phase. The preparation process is the same as in Example 1, except that the working pressure of the high-pressure homogenization is changed to 1000 Bar, and the amount of excipient glucose added to the suspension is 300 mg.

[0057] Detection: the average particle diameter of curcumol solid lipid nanoparticles is 123.4nm, and the encapsulation efficiency is 73.64%.

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Abstract

The invention provides a curcumenol solid lipid nanoparticle and its preparation method, which comprises curcumenol 1 part, phospholipids 3-10 parts, grease material 5-100 parts, surface active agent 10-200 parts and excipient 10-400 parts.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a solid lipid nanoparticle of the traditional Chinese medicine curcumol and a preparation method thereof. Background technique [0002] Curcmol, also known as turmeric epoxy alcohol, is a sesquiterpene compound extracted from zedoary volatile oil. Since the 1970s, it has been mainly used in the treatment of cervical cancer and has obtained obvious curative effects. In recent years, pharmaceutical workers have conducted extensive pharmacological studies on curcumol and found that it has direct inhibitory and destructive effects on Ehrlich ascites carcinoma in mice. In addition to being used to treat tumors, curcumol also has antibacterial and antiviral effects. From the appearance, curcumol is a colorless needle crystal. Curcumol is easily soluble in ether and chloroform, soluble in ethanol, slightly soluble in petroleum ether, almost insoluble in water, and its solubi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/343A61K9/127A61K9/19A61P35/00
Inventor 李学明徐元龙陈国广
Owner NANJING UNIV OF TECH
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