Medicine compound for curing cervical diseases

Abstract

The invention belongs to the technical field of medicine, and provides a medicine compound for curing cervical diseases. The medicine compound contains germacrone, furanodiene, curdione, beta-elemene, curcumenol, curzerene and borneol. The medicine compound has the advantages of clear composition and mass controllability; in the medicine compound, the weight parts of the curzerene and curcumenol are controlled, so the irritation of the medicine is reduced; and the medicine compound provided by the invention can be used for preparing suppositories, ointment, capsules, effervescent tablets, gels, lotions, membranes or foaming agents, achieves a good curative effect on HR-HPV (high-risk human papillomavirus) and / or LR-HPV (low-risk human papillomavirus) and the cervical diseases, and is suitable for clinical extensive use.

Description

technical field

[0001] The invention belongs to the technical field of medicines, and in particular relates to a pharmaceutical composition containing gemmacone, furadienes, curdione, β-elemene, curcumol, curcumene and borneol. Background technique

[0002] The zedoary oil extracted from the traditional Chinese medicine zedoary is the first clinically used drug for the treatment of cervical cancer in China, and it has been recorded in the Chinese Pharmacopoeia. The main chemical component of zedoary oil is sesquiterpenes; clinical practice has proved that the total effective rate of treating cervical cancer is 64.4%; it has a destructive effect on cancer tissue and has no obvious effect on normal tissue. Zedoary oil not only has a direct inhibitory effect on mouse Ehrlich's ascites cancer cells in vitro; moreover, the Ehrlich's ascites cancer cells that have been exerted by Curcuma can successfully make mice obtain obvious active immunity. Preliminary observations of pathom...

Examples

Embodiment 1

[0157] Prescription: Gemacerone 6g, furadienes 38.4g, curdione 11g, β-elemene 5g, curcumol 0.6g, curcumene 0.1g, borneol 75g.

[0158] Dosage form: suppository.

[0159] Preparation method: Mix the prescription amount of gemmacone, furadien, curdione, β-elemene, curcumol, curcumene with 64g polysorbate 80, dissolve 75g of borneol with an appropriate amount of ethanol, and mix with the above solution Mix well.

[0160] The polyoxyethylene stearate 1517g of prescription quantity is put on the water bath and is heated and melted, adds above-mentioned medicinal liquid, stirs, filling, makes 1000 suppositories, each 1.74g.

Embodiment 2～8

[0162] Prepare the suppository according to the following prescription, and the preparation method is the same as in Example 1.

[0163] Example

Embodiment 9

[0165] Prescription: Gemacerone 6.5g, furadienes 32g, curdione 21g, β-elemene 8.5g, curcumol 0.95g, borneol 35g.

[0166] Dosage form: effervescent tablet.

[0167] Preparation:

[0168] 1) Take β-cyclodextrin, add appropriate amount of water according to 25ml / g, stir to make it fully dissolved, and heat if necessary to obtain β-cyclodextrin solution; ene, curcumol, borneol 35g, diluted with absolute ethanol, slowly added to the β-cyclodextrin solution, continued to stir until a homogeneous phase was formed, placed in the refrigerator overnight, filtered with suction, washed 3 times with a small amount of petroleum ether, frozen, A white powder was obtained.

[0169] 2) Mix the above-mentioned white powder with 35g of borneol, 150g of citric acid and 160g of lactose; take another 120g of sodium bicarbonate and 160g of lactose, mix them evenly, and use 5% PVP absolute ethanol solution as a binder to granulate, at 50°C Dry, granulate, add appropriate amount of PEG6000, mix we...

technical field

[0001] The invention belongs to the technical field of medicines, and in particular relates to a pharmaceutical composition containing gemmacone, furadienes, curdione, β-elemene, curcumol, curcumene and borneol. Background technique

[0002] The zedoary oil extracted from the traditional Chinese medicine zedoary is the first clinically used drug for the treatment of cervical cancer in China, and it has been recorded in the Chinese Pharmacopoeia. The main chemical component of zedoary oil is sesquiterpenes; clinical practice has proved that the total effective rate of treating cervical cancer is 64.4%; it has a destructive effect on cancer tissue and has no obvious effect on normal tissue. Zedoary oil not only has a direct inhibitory effect on mouse Ehrlich's ascites cancer cells in vitro; moreover, the Ehrlich's ascites cancer cells that have been exerted by Curcuma can successfully make mice obtain obvious active immunity. Preliminary observations of pathom...

Examples

Embodiment 1

[0157] Prescription: Gemacerone 6g, furadienes 38.4g, curdione 11g, β-elemene 5g, curcumol 0.6g, curcumene 0.1g, borneol 75g.

[0158] Dosage form: suppository.

[0159] Preparation method: Mix the prescription amount of gemmacone, furadien, curdione, β-elemene, curcumol, curcumene with 64g polysorbate 80, dissolve 75g of borneol with an appropriate amount of ethanol, and mix with the above solution Mix well.

[0160] The polyoxyethylene stearate 1517g of prescription quantity is put on the water bath and is heated and melted, adds above-mentioned medicinal liquid, stirs, filling, makes 1000 suppositories, each 1.74g.

Embodiment 2～8

[0162] Prepare the suppository according to the following prescription, and the preparation method is the same as in Example 1.

[0163] Example

Embodiment 9

[0165] Prescription: Gemacerone 6.5g, furadienes 32g, curdione 21g, β-elemene 8.5g, curcumol 0.95g, borneol 35g.

[0166] Dosage form: effervescent tablet.

[0167] Preparation:

[0168] 1) Take β-cyclodextrin, add appropriate amount of water according to 25ml / g, stir to make it fully dissolved, and heat if necessary to obtain β-cyclodextrin solution; ene, curcumol, borneol 35g, diluted with absolute ethanol, slowly added to the β-cyclodextrin solution, continued to stir until a homogeneous phase was formed, placed in the refrigerator overnight, filtered with suction, washed 3 times with a small amount of petroleum ether, frozen, A white powder was obtained.

[0169] 2) Mix the above-mentioned white powder with 35g of borneol, 150g of citric acid and 160g of lactose; take another 120g of sodium bicarbonate and 160g of lactose, mix them evenly, and use 5% PVP absolute ethanol solution as a binder to granulate, at 50°C Dry, granulate, add appropriate amount of PEG6000, mix we...

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