4 results about "Active immunity" patented technology

The invention discloses a manganese-based layered hydroxide modified by gold nanoparticles and a preparation method thereof, and relates to the technical field of drug synthesis, and the key points of the technical scheme are as follows: the layered morphology of Mn-LDH is observed on the manganese-based layered hydroxide in a transmission electron microscope, and spherical AuNPs dispersed on the surface and edge of a laminate have a uniform particle size and a uniform particle size. EDS energy spectrum analysis finds that gold, manganese, magnesium, aluminum and carbon elements exist, the hydrated particle size is 312 nm, and the dispersity is good. The material can initiate an excellent photo-thermal effect under the irradiation of 808nm near-infrared light to generate active oxygen and hydroxyl radicals to destroy bacterial cell walls and cell membranes, and the antibacterial effect can reach 99%. In addition, the material can stimulate a local active immune function, promote T cell infiltration and realize active immune sterilization. The nano material shows a remarkable anti-infection effect in an in-vitro antibacterial experiment and an in-vivo osteomyelitis animal model experiment, and a new insight is provided for treating osteomyelitis caused by methicillin-resistant staphylococcus aureus.

The invention discloses a fermented ginseng-probiotic-natural antibacterial peptide composite oral liquid with an active immune defense function and a preparation method thereof, and belongs to the technical field of functional health food. The oral liquid is prepared by compounding a fermented ginseng matrix, an active probiotic preparation, a fly maggot source natural antibacterial peptide extract and auxiliary materials, and the activity of the components is guaranteed through a whole-course cold chain preparation process. On the basis of a microbial counterbalance theory, a human body active immune defense system is constructed by utilizing the synergistic effect of the fermented ginseng, the probiotics and the antibacterial peptide, and the limitation of traditional passive medical treatment is broken through; the shelf life of the product at 0-5 DEG C reaches 12 months, and the product is convenient to take and high in safety. The invention has the advantages of simple preparation process, wide raw material source and suitability for large-scale production, and has extremely high practical value in the field of human health protection.

The invention relates to the technical field of biological medicines, in particular to application of an METTL3 inhibitor in preparation of a medicine for enhancing antibacterial immunity of lungs. The m6A modification level of the AMs is regulated and controlled through an active immune enhancement scheme based on in-vivo pretreatment of an m6A inhibitor (STC-15), so that the ability of the AMs to swallow and remove bacteria is enhanced, and a brand-new host-oriented treatment thought is provided for resisting pulmonary infection.

The present invention provides a dynamic immune end-to-end trusted sharing method for multimodal data in a vehicle-road-cloud system, belonging to the field of information security technology. The method includes: using a vehicle-side or roadside unit with a digital certificate as the sending end, securely encapsulating the original multimodal data to generate a secure encapsulation result, and transmitting the secure encapsulation result to a cloud platform; using the cloud platform as the receiving end, recovering the original multimodal data; using the cloud platform to perform a trustworthiness assessment of the sending end based on the recovered original multimodal data (both current and historical), obtaining multi-dimensional assessment indicators; using a preset trust fusion model combined with the multi-dimensional assessment indicators to calculate and generate a dynamic trust value for the sending end; and triggering corresponding security handling strategies based on the dynamic trust value. This invention, through the synergistic linkage of dynamic trust value and security strategies, enables the system to possess adaptive perception and proactive immunity against internal threats, effectively ensuring the trustworthiness of shared data.