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Curcumenol solid dispersion and oral solid preparation thereof

A technology of solid dispersion and curcumol, which is applied in medical preparations with non-active ingredients, medical preparations containing active ingredients, pill delivery, etc., can solve the problems of low bioavailability of curcumol, low side effects, difficult To achieve industrialization and other issues, to achieve the effects of improving in vitro dissolution rate, improving poor oral absorption, and improving compliance

Inactive Publication Date: 2017-09-05
LIAONING UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the shortcomings of existing technical means and curcumol bioavailability in the existing preparations, such as low bioavailability, large side effects, inconvenient application, and difficulty in realizing industrialization, and provide a kind of curcumol with low side effects, high bioavailability, high safety, Curcumol solid dispersion and its oral preparation with less toxic and side effects and convenient application

Method used

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  • Curcumenol solid dispersion and oral solid preparation thereof
  • Curcumenol solid dispersion and oral solid preparation thereof
  • Curcumenol solid dispersion and oral solid preparation thereof

Examples

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preparation example Construction

[0021] A preparation method of curcumol solid dispersion, comprising

[0022] (1) Solvent method:

[0023] 1) Take the curcumol and the carrier material of the prescribed amount, dissolve them in a certain volume of organic solvent, and fully mix them;

[0024] 2) evaporate the organic solvent;

[0025] 3) Quickly cool down and solidify, pulverize and sieve to get the product.

[0026] (2) Melting method:

[0027] 1) Take the curcumol and the carrier material of the prescribed amount, heat and melt, and fully mix;

[0028] 2) Quickly cool down, crush and sieve after solidification, and obtain.

[0029] (3) Solvent-melt method:

[0030] 1) heating and melting the carrier material of the prescription amount, and dissolving the curcumol of the prescription amount in a certain volume of organic solvent;

[0031] 2) Add the upper drug solution into the molten carrier material under stirring conditions, and mix well;

[0032] 3) evaporate the organic solvent;

[0033] 4) Qui...

Embodiment 1

[0037] Embodiment 1 adopts solvent method to prepare curcumol solid dispersion

[0038]

[0039] Preparation process: Weigh curcumol and PEG-4000 according to a certain ratio (in the experimental process of the present invention, the ratio listed in the above table is examined), add it to absolute ethanol, stir and dissolve at 60 ° C, mix well, dry under reduced pressure, and evaporate the organic Solvent, placed in the refrigerator to make it quickly and fully solidified, crushed and sieved to obtain.

Embodiment 2

[0040] Embodiment 2 adopts solvent method to prepare curcumol solid dispersion

[0041]

[0042] Preparation process: Weigh curcumol and PEG-6000 according to a certain ratio (in the experimental process of the present invention, the ratio listed in the above table is checked), add it to absolute ethanol, stir and dissolve at 60°C, mix well, dry under reduced pressure, and evaporate the organic Solvent, placed in the refrigerator to make it quickly and fully solidified, crushed and sieved to obtain.

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Abstract

The invention discloses curcumenol solid dispersion and an oral solid preparation thereof. The solid dispersion is composed of curcumenol and a carrier material, wherein a weight ratio of the curcumenol to the carrier material is 1:1 to 1:11. The oral solid preparation can be tablets, capsules or granules and has the advantages of low side effects, high bioavailability, high safety, small toxic and side effects, convenience in application and the like.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a curcumol solid dispersion and an oral solid preparation thereof. Background technique [0002] Zedoary is also known as black ginger, blue ginger, black ginger, alias Jiangqi, blue heart ginger; it belongs to the perennial herbaceous plant of the genus Curcuma in the family Zingiberaceae. It is mainly used to treat diseases such as bloating and pain in trusted subordinates, stagnation of Qi and blood, accumulation of Qi and blood, lumps in the abdomen, amenorrhea due to blood stasis in women, inability to eat and drink, and pain from bruises. Zedoary is rich in volatile oil, and its composition is quite complex, mainly sesquiterpenes and sesquiterpenes. Modern pharmacological studies have found that the extract of Curcuma Curcumae - Zedoary Curcuma Volatile Oil has good anti-tumor, anti-inflammatory and anti-viral effects. It has been confirmed that the an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/352A61K47/10A61K47/32A61K47/14A61K47/38A61K47/18A61K47/12A61K9/48A61K9/16A61K9/20A61P35/00A61P31/12A61P31/04A61P31/10A61P35/02
CPCA61K31/352A61K9/0056A61K9/145A61K9/146A61K9/1652A61K9/2054A61K9/4808
Inventor 陈立江王朝勃赵京华刘宇
Owner LIAONING UNIVERSITY
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