32results about How to "Timed release" patented technology

The invention discloses a preparation method of a mesoporous apatite nano-drug carrier with pH responsiveness and cellular targeting property for a hepatoma cell, belonging to the field of biomedical materials. The invention aims at solving the technical problems that the drug delivery capacity is relatively low and the in-vivo toxic and side effects of a drug are enhanced because a carrier prepared by using the existing method cannot specifically recognize a target cell, most of drug molecules are distributed in normal tissues and are absorbed by normal cells, but the dosage of the drug distributed in pathological tissues is relatively small. The preparation method comprises the steps of firstly, preparing a template agent; secondly, preparing a mesoporous hydroxylapatite nanoparticle; thirdly, aminating mesoporous hydroxylapatite; fourthly, borating mesoporous apatite; fifthly, preparing lactobionic acid functionalized bovine serum albumin; and sixthly, preparing the mesoporous apatite nano-drug carrier with pH responsiveness and cellular targeting property. The mesoporous apatite nano-drug carrier prepared by using the preparation method can be used for recognizing hepatoma cells in a targeting way, so that the uptake of the normal tissues to the drug is reduced, and the in-vivo toxic and side effects of the drug are reduced.

The invention relates to the field of anticorrosive paint, in particular to a sulfur ion response type nano container, application of the sulfur ion response type nano container as a microbial corrosion (sulfate reducing bacteria corrosion) intelligent protective coating material and a preparation method of the coating material. Hollow mesoporous silica nanoparticles (HMSNs) are taken as a core, 2-methylimidazole zinc salt (ZIF-8) is taken as a shell (a nano valve), and a bactericide is loaded in a cavity of the HMSNs, so that the target nano container is obtained. The microbial corrosion intelligent protective coating based on the sulfur ion response type nano container can actively respond to the change of the concentration of microenvironment sulfur ions caused by sulfate reducing bacteria, fixed-point, timed and quantitative controlled release of the bactericide is achieved, and the released bactericide plays a role in sterilization and microbial corrosion protection; and the problems of shortening of the service life of the coating, improvement of the cost, environmental problems caused by excessive release of the bactericide and microbial drug resistance due to spontaneous leakage of the bactericide in the past are avoided.

The invention provides a limiting mechanism for a photovoltaic power generation equipment cleaning device. The limiting mechanism comprises photovoltaic power generation equipment which is arranged ina rotary swinging manner, guide rails which are symmetrically arranged on the two sides of the photovoltaic power generation equipment respectively and a cleaning roll which is rotationally arrangedon the guide rails; each guide rail comprises a linear guide rail and an arch-shaped guide rail; each linear guide rail is slantingly arranged; each arch-shaped guide rail is connected with the two ends of the corresponding linear guide rail; and limiting mechanisms, each of which comprises a fixing component and a lever component, are arranged on the tops of the linear guide rails respectively. The limiting mechanism provided by the invention has the beneficial effects that by utilizing locking of first limiting plates and the corresponding linear guide rails to limit the cleaning roll and through transmission matching between the lever components and the photovoltaic power generation equipment, locking between the first limiting plates and the corresponding linear guide rails is unlocked, the technical problem of limiting of the photovoltaic power generation equipment cleaning device is solved, regular release and limiting of the cleaning roll are realized, and the structure is novel.

The invention relates to the fields of nano-biomedicines and nano-materials, in particular to a method for preparing an organic metal complex anticancer drug by electrostatic spinning technology. The specific steps of the method are as follows: solution A and solution B are respectively prepared; the solution A and the solution B are evenly mixed and then ejected by a nozzle needle; the ambient temperature is controlled at 18-20 DEG C and the ambient humidity is 45%-50%; the space between collecting shields is 14-15cm, the voltage is 10-20KV, and the mass velocity of an injection pump is 2-8mL/h; and aluminum foil collecting product fiber is arranged at collecting shield. The method of the invention can control the drug content, thickness of the shell layer, fineness of the micro/nanometer fiber, and the like, of the product only by controlling the conditions such as drug content, voltage, flow rate of the nozzle needle, etc., by which the position and time specific release of the drugs is expected to realize, and a new carrier for oral administration of some medicines is expected to be provided. By adopting the method, micro/nanometer drug fiber membrane with large area and great thickness can be spun in a short time. The method has the advantages of high drug recovery rate, large single-time output of the product, easy storage of the product, and the like, thus being valuable for industrial application and expected to be expanded to a large-scale application.

The invention discloses a preparation method of a three-layer core-shell structure drug carrier with a near-infrared light remote response, belongs to the field of biomedical materials, particularly relates to a preparation method of a three-layer core-shell structure drug carrier with a near-infrared light remote response, and aims at solving the problem that cell imaging, photoactive therapy and light-controlled drug release cannot be simultaneously carried out by an existing method. The method comprises the following steps: with up-conversion nano-particles as a core, wrapping a solid silicon shell for embedding a photosensitizer methylene blue; wrapping the outmost layer mesoporous silica shell; loading a model drug rhodamine B with a mesoporous internal channel; carrying out surface modification on three-layer core-shell nano-particles to modify organic chain link molecules with a singlet oxygen response on the outer surface; connecting the link molecules with a guest molecule AD in a chemical bonding manner; and loading a drug into a mesopore, and then complexing the guest molecule AD and added beta-cyclodextrin to block the channel. The preparation method is applied to cancer diagnosis and treatment; and light-controlled drug release, photoactive therapy and cell imaging are realized in a trinity manner.

The invention relates to an ocean platform device and especially relates to a quick releasing hook for an ocean platform. The quick releasing hook comprises a shell, a hook body, a sliding arm and a sliding block, wherein the sliding arm is arranged above the hook body; the sliding block is arranged above the sliding arm; the sliding arm and the sliding block are both arranged in the shell; the sliding arm and the sliding block both move up and down along the shell; the hook body comprises a left hook body and a right hook body which are symmetrically arranged; the middle lower parts of the left hook body and the right hook body are in rotatable connection with each other through a rotating shaft III; a spring is arranged on the rotating shaft III; the rotating shaft III is in rotatable connection with the shell; the upper ends of the right hook body and the left hook body are arranged in the shell; the lower ends of the right hook body and the left hook body are arranged under the shell. The timing, accurate and quick releasing of the ocean objects can be realized and the releasing accuracy of the ocean objects can be guaranteed.

The invention belongs to the field of food processing, and particularly relates to a sausage and a processing method thereof. The sausage contains Allium macrostemon Bunge which accounts for 0.3-20 wt% of the sausage. The preparation method comprises the following steps: mincing fresh meat according to the formula amount, pickling with seasonings, and evenly mixing with Allium macrostemon Bunge and auxiliary materials, wherein the weight ratio of Allium macrostemon Bunge to auxiliary materials is (0.5-5):1, and the auxiliary materials contain black tea or Pu-Erh tea which accounts for 30-70 wt% of the auxiliary materials; and filling the fresh sausage, and volatilizing 15-40% of water. The sausage has the advantages of good mouthfeel and favorable color, and is applicable to patients with overhigh blood fat; by replacing the spice garlic with Allium macrostemon Bunge, the sausage has an intense garlic flavor; a proper amount of Allium macrostemon Bunge can obviously lower the generation amount of nitrites in the subsequent processing on the premise of ensuring the sausage mouthfeel; and in the sausage boiling process, the Allium macrostemon Bunge mixed in the sausage eliminates the slow release and timed release of effective constituents of nitrites, thereby thoroughly eliminating nitrites.

The invention relates to the field of medicines, in particular to a medicinal preparation, a medicinal transdermal patch containing the medicinal preparation and a preparation method of the medicinaltransdermal patch. The medicinal preparation comprises a coated medicine and an uncoated medicine, wherein the coated medicine comprises a medicine A and an inclusion material coating the medicine A;the inclusion material contains lipid; the uncoated medicine is a medicine B; and the medicine A and the medicine B are the same or different. The medicinal preparation and the medicinal transdermal patch provided by the invention have the advantages that an effective dose of medicine can be stably and durably (capable of reaching 7 days) released, and in addition, the controllability is high, sothat the medication requirements of patients of different degrees can be met.

The invention relates to the field of medicines, and particularly relates to an oral mucosa drug delivery system. The oral mucosa drug delivery system comprises a matrix and inclusion particles dispersed in the matrix, wherein the inclusion particles comprise a drug A and an inclusion material wrapping the drug A; the inclusion particles contain lipid, and the lipid accounts for 60-100wt% of the weight of the inclusion material; and the matrix optionally further contains a drug B, and the drug B is the same as or different from the drug A. The drug release of the oral mucosa drug delivery system can be more stable, side effects caused by concentration fluctuation are avoided, and the drug can be continuously released for a longer time.

The invention relates to the field of medicine, in particular to a medicinal preparation, a medicinal transdermal patch containing the medicinal preparation and a preparation method of the medicinal transdermal patch. The medicinal preparation comprises coated medicine and uncoated medicine; the coated medicine comprises medicine A and an inclusion material coating the medicine A; the inclusion material contains hyaluronic acid and/or a derivative of the hyaluronic acid; the uncoated medicine is medicine B; and the medicine A and the medicine B are the same or different. The medicinal preparation and the medicinal transdermal patch provided by the invention have the advantages that an effective dose of medicine can be stably and durably (capable of reaching 7 days) released, and in addition, the controllability is high, so that the medication requirements of patients of different degrees can be met.

The invention provides an ROS-sensitive polyethylene glycol-polyester nano-drug delivery system which is characterized by comprising an ROS-sensitive polyethylene glycol hydrophilic segment A and a polyester hydrophobic segment B, and the hydrophilic and hydrophobic segments are linked by ROS-sensitive bonds to form A-B and B-A-B copolymers. The ROS sensitive material provided by the invention at least has one of the following advantages: the polymer material provided by the invention can be used for preparing a nano drug carrying material, drug wrapping is carried out through polymer self-assembly, drug molecules can be stabilized, ROS response sensitive release can be realized, and oral administration and the like can be realized.

The invention relates to the field of medicines, in particular to a medicinal preparation, a medicinal transdermal patch containing the medicinal preparation and a preparation method of the medicinaltransdermal patch. The pharmaceutical preparation comprises a coated drug and an uncoated drug, wherein the coated drug comprises a drug A and an inclusion material coating the drug A, and the inclusion material contains chitosan and/or derivatives thereof; the uncoated drug is a drug B; and the drug A and the drug B are the same or different. The medicinal preparation and the medicinal transdermal patch can release an effective dose of drugs lastingly (7 days) and stably, and have stronger controllability so as to meet the medication requirements of patients with different degrees.

The invention discloses a marine storage tank with a timed ventilation function. The marine storage tank comprises a round bearing tank, a timed ventilation mechanism is arranged on the upper surface of the round bearing tank, a buffering supporting mechanism is arranged on the lower surface of the round bearing tank, a fixing mechanism is arranged on the side surface of the round bearing tank, and the front surface of the round bearing tank is fixedly connected with a control box body; and a timer, a wireless signal projector and a wireless signal receiver are arranged in the control box body. The marine storage tank with the timed ventilation function has the beneficial effects that the marine storage tank is a device which is convenient to use, can allow liquid to flow in and out conveniently, can conduct effective buffering on shaking of a ship body, can conduct timed releasing on energy gathered inside the storage tank, ensures the safety of the internal liquid, facilitates remote control and is convenient to store and transport.

The invention provides a liquid reagent storage and controlled release device. The liquid reagent storage and controlled release device is used for realizing timed and controllable release after liquid storage, has no liquid residue and reduces the influence of the residual reagents on the subsequent detection accuracy. In order to achieve the purpose, the disclosed liquid storage and controlled release assembly comprises a liquid storage device and a metal ring paraffin valve, wherein the metal ring paraffin valve is composed of a metal ring and paraffin filled in the metal ring, an opening of the liquid storage device matches with the outer diameter of the metal ring, the opening of the liquid storage device is blocked by the metal ring paraffin valve, the liquid storage device is of a bottle-shaped structure, and the metal ring is of a cylindrical hollow annular structure.

The invention discloses a solar cell panel surface cleaning device for photovoltaic power generation. The solar cell panel surface cleaning device comprises mounting frames, and a photovoltaic cell panel, a supporting plate, a water collecting structure, an ice coating thermalization assembly and a cleaning structure which are mounted between the mounting frames. The water collecting structure comprises a main water tank, a water collecting hopper, a filter screen plate, an auxiliary water tank and a plurality of overflow grooves; mud blocking nets are installed in the multiple overflow grooves. The icing thermalization assembly comprises a heat preservation lining plate electric heating rod. The cleaning structure comprises an electric push rod, a supporting frame, a blocking plate and a flushing plate. According to the invention, by utilizing a simple sedimentation replacement principle of a water body, the cleanliness of rainwater collection can be improved, and the cleaning effect of a photovoltaic cell panel is improved; under the action of the ice coating thermalization assembly cooperating with the water collection structure, the cleaning use of dust, stains and ice coating of the photovoltaic cell panel can be met, and the cleaning is multifunctional; the cleaning work of the photovoltaic cell panel is met through the simple drainage principle of clean water, the photovoltaic cell panel is fully cleaned, and the design cost of the cleaning structure is low.