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Oral mucosa drug delivery system

A drug delivery system and oral mucosal technology, applied in the field of medicine, can solve the problems of Parkinson's patients' difficulties, upper respiratory tract infection sputum, impaired motor function, etc., and achieve the effect of reducing adverse reactions, avoiding side effects, and reducing irritation

Active Publication Date: 2020-12-15
江苏集萃新型药物制剂技术研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In the "switch" fluctuations in the treatment of Parkinson's disease within 5 to 30 minutes, the marketed drugs include levodopa inhalation, subcutaneous injection of apomorphine and apomorphine sublingual film. Levodopa often causes side effects such as cough, nausea, upper respiratory tract infection, and sputum discoloration; clinical data on apomorphine sublingual film found that sublingual administration of apomorphine caused stomatitis, nausea, vomiting, etc.; and due to impaired motor function, Subcutaneous apomorphine is difficult for Parkinson's patients

Method used

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  • Oral mucosa drug delivery system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment A1

[0063]Mix 0.25 g of rotigotine with 0.53 g of molten glyceryl monostearate as a lipid and 0.23 g of lecithin as an emulsifier, melt at 80°C, and pass the molten mixture through a high-pressure homogenizer to make colostrum. Homogenize 4 times under a high pressure of 120MPa, cool, and dry to obtain coated particles with an average particle size of 578nm.

Embodiment A2

[0065]0.28g of rotigotine was mixed with 0.54g of molten behenic acid diglyceride as a lipid and 0.18g of sodium taurocholate as an emulsifier, melted at 75℃, and the molten mixture was subjected to a high-pressure homogenization mechanism Colostrum is homogenized 4 times under high pressure of 110MPa and cooled to obtain coated particles with an average particle size of 456nm.

Embodiment A3

[0067]Mix 0.2g of rotigotine with 0.64g of molten glyceryl citrate as a lipid and 0.16g of sodium lauryl sulfate as an emulsifier, melt at 85°C, and pass the molten mixture through a high-pressure homogenizer. The colostrum is homogenized 4 times under a high pressure of 130MPa, cooled and dried to obtain coated particles with an average particle size of 632nm.

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Abstract

The invention relates to the field of medicines, and particularly relates to an oral mucosa drug delivery system. The oral mucosa drug delivery system comprises a matrix and inclusion particles dispersed in the matrix, wherein the inclusion particles comprise a drug A and an inclusion material wrapping the drug A; the inclusion particles contain lipid, and the lipid accounts for 60-100wt% of the weight of the inclusion material; and the matrix optionally further contains a drug B, and the drug B is the same as or different from the drug A. The drug release of the oral mucosa drug delivery system can be more stable, side effects caused by concentration fluctuation are avoided, and the drug can be continuously released for a longer time.

Description

Technical field[0001]The invention relates to the field of medicine, in particular to an oral mucosal drug delivery system.Background technique[0002]Parkinson's disease is a common degenerative disease of the nervous system in middle-aged and elderly people. It is mainly characterized by progressive degeneration of substantia nigra dopaminergic neurons and pathological changes in the formation of Lewy bodies. Dopamine transmitters in the striatum are reduced, The biochemical changes of the imbalance of dopamine and acetylcholine transmitter, the clinical manifestations of non-motor symptoms such as tremor, muscle rigidity, retardation, postural balance disorder and hypoosmia, constipation, abnormal sleep behavior and depression are notable features.[0003]The cause of Parkinson's disease is still unclear, but it is generally believed to be related to genetic and environmental factors. People with Parkinson's disease in the family are more likely to get this disease, and those who hav...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K45/06A61K47/14A61K47/24A61K47/28A61K47/22A61K47/34A61K47/38A61P25/16A61K9/08A61K9/20A61K9/50
CPCA61K9/0056A61K9/006A61K9/08A61K9/2054A61K9/5015A61K9/7007A61K45/06A61K47/34A61K47/38A61P25/16
Inventor 全丹毅徐文婷
Owner 江苏集萃新型药物制剂技术研究所有限公司
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