Method for preparing organic metal compound anti-cancer medicine with electrostatic spinning technique

An electrospinning technology and organometallic technology, applied in the field of nano-biomedicine and materials, can solve the problems of severe nephrotoxicity, nausea and vomiting, cisplatin restriction, etc., and achieve low production cost, simple preparation process, and large single-time output Effect

Inactive Publication Date: 2009-01-21
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although cisplatin drugs have strong anticancer effects, they have severe nephrotoxicity, neurotoxicity, gastrointestinal toxicity, and ototoxicity, as well as side effects such as nausea and vomiting during use. restricted
At present, there are no research reports on the micronanoization of organometallic anticancer drugs by electrospinning technology to improve their anticancer properties

Method used

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  • Method for preparing organic metal compound anti-cancer medicine with electrostatic spinning technique
  • Method for preparing organic metal compound anti-cancer medicine with electrostatic spinning technique
  • Method for preparing organic metal compound anti-cancer medicine with electrostatic spinning technique

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 1) Accurately measure PLLA (the mass ratio of PLLA in dichloromethane solvent is 5wt%) solute and dichloromethane solvent with an analytical balance, place in a clean glass dish and stir for about 2 hours under the action of a magnetic stirrer until completely dissolved , to obtain solution A. Accurately measure titanocene dichloride (the mass ratio of titanocene dichloride is 0.4wt%) solute and dichloromethane solvent with an analytical balance, place in a clean glass dish and stir for 2.5 hours under the action of a magnetic stirrer until completely dissolved , to obtain solution B.

[0031] 2) Mix solution A and solution B evenly and add to the liquid storage tube, and spray it out from the spray needle under the condition of voltage applied by the high-voltage electrostatic generator. The controlled environment temperature is 18-20°C; the ambient humidity is 45%-50%; the distance between the collecting screens is 14-15 cm. The voltage is 14.0KV; the mass flow rate...

Embodiment 2

[0034] 1) Accurately measure PLLA (the mass ratio of PLLA is 5wt%) and dichloromethane solvent with an analytical balance, place in a clean glass dish and stir for about 2 hours under the action of a magnetic stirrer until completely dissolved to obtain solution A. Accurately measure titanocene dichloride (the mass ratio of titanocene dichloride is 0.6wt%) solute and dichloromethane solvent with an analytical balance, place in a clean glass dish and stir for about 2 hours under the action of a magnetic stirrer until completely dissolved , to obtain solution B.

[0035]2) Mix solution A and solution B evenly and add to the liquid storage tube, and spray it out from the spray needle under the condition of voltage applied by the high-voltage electrostatic generator. The controlled environment temperature is 18-20°C; the ambient humidity is 45%-50%; the distance between the collecting screens is 14-15 cm. The voltage is 16.0KV; the mass flow rate of the syringe pump is 6.0mL / h; t...

Embodiment 3

[0038] 1) Accurately measure PLLA (the mass ratio of PLLA is 5wt%) and dichloromethane solvent with an analytical balance, place in a clean glass dish and stir for about 2 hours under the action of a magnetic stirrer until completely dissolved to obtain solution A. Accurately measure titanocene dichloride (the mass ratio of titanocene dichloride is 0.8wt%) solute and dichloromethane solvent with an analytical balance, place in a clean glass dish and stir for about 2 hours under the action of a magnetic stirrer until completely dissolved , to obtain solution B.

[0039] 2) Solution A and solution B are mixed and sprayed out from the spray needle. The controlled environment temperature is 18-20°C; the ambient humidity is 45%-50%; the distance between the collecting screens is 14-15 cm. The voltage is 16.0KV; the mass flow rate of the syringe pump is 6.0mL / h; the product fibers are collected at the collection screen. The obtained product is micron-sized, with a size range of 18...

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Abstract

The invention relates to the fields of nano-biomedicines and nano-materials, in particular to a method for preparing an organic metal complex anticancer drug by electrostatic spinning technology. The specific steps of the method are as follows: solution A and solution B are respectively prepared; the solution A and the solution B are evenly mixed and then ejected by a nozzle needle; the ambient temperature is controlled at 18-20 DEG C and the ambient humidity is 45%-50%; the space between collecting shields is 14-15cm, the voltage is 10-20KV, and the mass velocity of an injection pump is 2-8mL / h; and aluminum foil collecting product fiber is arranged at collecting shield. The method of the invention can control the drug content, thickness of the shell layer, fineness of the micro / nanometer fiber, and the like, of the product only by controlling the conditions such as drug content, voltage, flow rate of the nozzle needle, etc., by which the position and time specific release of the drugs is expected to realize, and a new carrier for oral administration of some medicines is expected to be provided. By adopting the method, micro / nanometer drug fiber membrane with large area and great thickness can be spun in a short time. The method has the advantages of high drug recovery rate, large single-time output of the product, easy storage of the product, and the like, thus being valuable for industrial application and expected to be expanded to a large-scale application.

Description

technical field [0001] The invention belongs to the technical field of nanobiological medicine and materials, and in particular relates to a method for preparing organic metal composite anticancer drugs by electrospinning technology. Background technique [0002] Cancer is one of the major diseases that seriously endanger human health, and cancer has become the second largest killer after cardiovascular disease. Conquering cancer has always been a research topic attracting worldwide attention. According to the research of the World Health Organization, the number of cancer patients is increasing year by year. At present, people have conducted extensive research on cancer, especially the research on anticancer drugs. [0003] In 1979, Koepf of the Technical University of Berlin reported Cp for the first time. 2 TiCl 2 anticancer activity and has been systematically studied. It was found that titanocene dichloride has broad-spectrum anticancer activity and exhibits weak c...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/28A61K47/34A61P35/00D01F6/92D01F1/10D01D5/00
Inventor 吴庆生陈平丁亚平张琨朱子春李升陈义军
Owner TONGJI UNIV
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