A preparation method of a three-layer core-shell structure drug carrier with near-infrared light remote response

A technology of near-infrared light and shell structure, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulations, and can solve the problem of simultaneous cell imaging, photokinetic therapy, and light-controlled drug release. To achieve the effect of avoiding drug resistance and drug resistance of cancer cells, high precision of controlled release, and guaranteed curative effect

Active Publication Date: 2017-07-28
HARBIN INST OF TECH
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  • Summary
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  • Claims
  • Application Information

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Problems solved by technology

[0004] In order to solve the problem that existing methods cannot perform cell imaging, photokinetic therapy and photocontrolled drug release at the same time, the present invention provides a preparation method of a three-layer core-shell structure drug carrier with near-infrared light remote response

Method used

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  • A preparation method of a three-layer core-shell structure drug carrier with near-infrared light remote response
  • A preparation method of a three-layer core-shell structure drug carrier with near-infrared light remote response
  • A preparation method of a three-layer core-shell structure drug carrier with near-infrared light remote response

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specific Embodiment approach 1

[0026] Embodiment 1: The preparation method of a three-layer core-shell structure drug carrier with near-infrared light remote response in this embodiment is specifically carried out according to the following steps:

[0027] 1. NaYF 4 : Yb / Er upconversion nanoparticles are dispersed in cyclohexane to obtain upconversion nanoparticle cores;

[0028] 2. Dissolve the surfactant CO-520 in cyclohexane at room temperature and stir magnetically for 15 to 30 minutes to obtain a mixed solution. Add the up-conversion nanoparticle core, photosensitizer and ammonia water obtained in step 1 to the mixed solution at room temperature. Stir at low temperature for 20min to 40min; then add tetraethoxysilane dropwise, stir at room temperature for 20h to 26h, centrifuge to obtain a solid, wash the solid with ethanol for 3 to 5 times, and then disperse it in deionized water to obtain a coating Upconverting nanoparticles with photosensitizers;

[0029] 3. Add the up-converting nanoparticles coat...

specific Embodiment approach 2

[0037] Embodiment 2: This embodiment differs from Embodiment 1 in that the volume ratio of the surfactant CO-520 described in step 2 to cyclohexane is 1 mg:(0.01-0.02) mL. Other steps and parameters are the same as those in the first embodiment.

specific Embodiment approach 3

[0038] Specific embodiment three: the difference between this embodiment and specific embodiment one or two is that the quality of the surfactant CO-520 described in step two and the up-conversion nanoparticle core volume ratio obtained in step one are 1mg: (0.01~ 0.02) μL. Other steps and parameters are the same as those in Embodiment 1 or 2.

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Abstract

The invention discloses a preparation method of a three-layer core-shell structure drug carrier with a near-infrared light remote response, belongs to the field of biomedical materials, particularly relates to a preparation method of a three-layer core-shell structure drug carrier with a near-infrared light remote response, and aims at solving the problem that cell imaging, photoactive therapy and light-controlled drug release cannot be simultaneously carried out by an existing method. The method comprises the following steps: with up-conversion nano-particles as a core, wrapping a solid silicon shell for embedding a photosensitizer methylene blue; wrapping the outmost layer mesoporous silica shell; loading a model drug rhodamine B with a mesoporous internal channel; carrying out surface modification on three-layer core-shell nano-particles to modify organic chain link molecules with a singlet oxygen response on the outer surface; connecting the link molecules with a guest molecule AD in a chemical bonding manner; and loading a drug into a mesopore, and then complexing the guest molecule AD and added beta-cyclodextrin to block the channel. The preparation method is applied to cancer diagnosis and treatment; and light-controlled drug release, photoactive therapy and cell imaging are realized in a trinity manner.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a preparation method of a three-layer core-shell structure drug carrier with near-infrared light remote response. Background technique [0002] In recent years, with the rapid development of nanomedicine science, the construction of a multifunctional diagnosis and treatment platform integrating multiple treatments and imaging diagnosis has become the current development trend of cancer treatment. Rare-earth-doped up-conversion luminescent nanoparticles, under the excitation of near-infrared light, can produce multi-band emission in the visible and ultraviolet regions (wherein a certain band of light is used for imaging, and other bands of light are used for treatment), so in The construction of a multifunctional cancer diagnosis and treatment platform has attracted much attention. At present, the research reports based on the diagnosis and treatment platform of up...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K49/00A61K47/24A61K47/40
Inventor 王浩王铀
Owner HARBIN INST OF TECH
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