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Preparation method of a core-shell structure drug carrier for near-infrared light-excited supramolecular valve light-controlled drug release

A technology of core-shell structure and near-infrared light, which is applied to the photodissociation of drugs in the body, non-active ingredients of polymer compounds, and medical preparations of non-active ingredients, etc. Control release and other issues to achieve the effect of strong penetration ability of organisms and small cell damage

Active Publication Date: 2018-12-11
黑龙江省工研院资产经营管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The present invention is to solve the problem that the diagnosis and treatment reagents cannot be controlledly released in time, space and dosage, and provides a method for preparing a drug carrier with a core-shell structure that excites supramolecular valves for light-controlled release of drugs by near-infrared light

Method used

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  • Preparation method of a core-shell structure drug carrier for near-infrared light-excited supramolecular valve light-controlled drug release
  • Preparation method of a core-shell structure drug carrier for near-infrared light-excited supramolecular valve light-controlled drug release
  • Preparation method of a core-shell structure drug carrier for near-infrared light-excited supramolecular valve light-controlled drug release

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specific Embodiment approach 1

[0031] Specific Embodiment 1: The preparation method of a core-shell structure drug carrier of a near-infrared light-excited supramolecular valve light-controlled drug release in this embodiment is specifically carried out according to the following steps:

[0032] 1. Synthesis of upconversion nanoparticle core: NaYF 4 : Yb / Tm up-conversion nanoparticles are dispersed in cyclohexane to obtain up-conversion nanoparticles cores;

[0033] 2. Synthesis of up-conversion nanoparticles coated with shells: adding oleic acid, octadecene and the up-conversion nanoparticles core obtained in step 1 to yttrium chloride hexahydrate to obtain a reaction system, under the conditions of argon protection and stirring The temperature of the reaction system was raised from room temperature to 160°C, and stirred for 1.5h under the protection of argon at a temperature of 160°C, then the temperature was naturally cooled from 160°C to 50°C, then the mixed solution A was added, and then Stir for 0.5h...

specific Embodiment approach 2

[0044] Specific embodiment two: the difference between this embodiment and specific embodiment one is that the volume ratio of the mass of yttrium chloride hexahydrate described in step two to oleic acid is 1mg:0.035mL. Other steps and parameters are the same as those in the first embodiment.

specific Embodiment approach 3

[0045] Specific embodiment three: this embodiment is different from specific embodiment one or two in that: the volume ratio of the mass of yttrium chloride hexahydrate described in step two to octadecene is 1mg:0.098mL. Other steps and parameters are the same as those in Embodiment 1 or 2.

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Abstract

The invention belongs to the field of biomedical materials, particularly relates to a preparing method of a core-shell structure drug carrier with near-infrared light exciting supermolecule valve light control drug release, and aims to solve the problems that a diagnosis and treatment agent cannot be controllably released in the aspects of time, space and dosage. The method includes the steps that upconversion nano particle cores are synthesized; upconversion nano particles with shells coated are synthesized; the outer layers of the upconversion nano particles are coated with mesoporous silica; the outer surfaces of the core-shell structure nano particles are modified with amino groups; surfactant is removed to form mesoporous; the outer surfaces of the core-shell structure nano particles are modified with guest molecules; doxorubicin hydrochloride is loaded, and pore passages are blocked. The core-shell structure drug carrier is used in cancer treatment, and timing and quantitative controlled release of anti-cancer drugs in tumor tissue is achieved.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a method for preparing a drug carrier with a core-shell structure for near-infrared light-excited supramolecular valve light-controlled drug release. Background technique [0002] With the rapid development of nanomedicine, it has become an important development of nanomedicine science to design and build an intelligent responsive nanomolecular valve cancer treatment platform, which can deliver anticancer drugs to cancer tissues without leakage, enrich them at the lesion site and release them in a controlled manner. direction. At present, the intelligent response methods for external stimuli used to open molecular valves mainly include pH, redox, enzymes, light, and heat. Among them, the pH, redox, and enzyme responses are controlled release in vivo, and the response sensitivity is poor, so it is difficult to precisely control. The light-responsive system is favo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K9/14A61K47/02A61K47/04A61K47/40A61K31/704A61P35/00
CPCA61K9/0009A61K9/143A61K9/146A61K31/704A61K41/0042
Inventor 王铀韩仁璐
Owner 黑龙江省工研院资产经营管理有限公司
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