A preparation method of mesoporous apatite nano drug carrier with pH responsive core-shell structure

A nano-drug carrier, mesoporous apatite technology, applied in phosphorus compounds, drug combinations, pharmaceutical formulations, etc., can solve the problems of poor water solubility of carriers and small drug loading, and achieve large drug loading, low cytotoxicity, Responsive effect
CN104548108BActive Publication Date: 2017-06-20HARBIN INST OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HARBIN INST OF TECH
Publication Date
2017-06-20

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Abstract

The invention discloses a preparation method of a mesoporous apatite nano drug carrier with a pH responsive core-shell structure. The invention belongs to the field of biological medical materials and in particular relates to a preparation method of a mesoporous apatite nano drug carrier with a pH responsive core-shell structure in order to solve the problems of small drug carrying capacity and poor carrier water solubility in the prior art. The preparation method comprises the following steps: 1, preparing an F127-calcium pantothenate mixed solution; 2, preparing mesoporous hydroxyapatite nano-particles; 3, performing amination on mesoporous hydroxyapatite; 4, preparing polyacrylic acid-mesoporous apatite nano-particles; and 5, preparing the mesoporous apatite nano drug carrier with the pH responsive core-shell structure. The mesoporous apatite nano drug carrier with the pH responsive core-shell structure, prepared by the method disclosed by the invention, has fast pH responsivity, is large in drug carrying capacity and small in toxic or side effect in an organism, can be applied to clinical treatment of cancers, and has an important application prospect.
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Description

technical field

[0001] The invention belongs to the field of biomedical materials, and in particular relates to a method for preparing a mesoporous apatite nano-medicine carrier with a pH-responsive core-shell structure. Background technique

[0002] Cancer is one of the major problems facing the medical field today, and chemotherapy is an indispensable means of cancer treatment. However, traditional chemotherapy has disadvantages such as high toxicity and side effects, low drug bioavailability, and lack of specific recognition, which limit its application and development in cancer treatment. The emergence and development of intelligent response drug controlled release system is expected to solve the problems in chemotherapy. Using nanomaterials as the carrier of anti-tumor drugs to construct a new type of intelligent response system can realize the slow release of drugs and stabilize the blood concentration, thereby reducing its toxic and side effects on patients and impro...

Claims

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