A preparation method of mesoporous apatite nano drug carrier with pH responsive core-shell structure

A nano-drug carrier, mesoporous apatite technology, applied in phosphorus compounds, drug combinations, pharmaceutical formulations, etc., can solve the problems of poor water solubility of carriers and small drug loading, and achieve large drug loading, low cytotoxicity, Responsive effect

Active Publication Date: 2017-06-20
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims to solve the problems of small drug load and poor water solubility of the carrier in the existing method, and provides a preparation method of a mesoporous apatite nano-medicine carrier with a pH-responsive core-shell structure

Method used

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  • A preparation method of mesoporous apatite nano drug carrier with pH responsive core-shell structure
  • A preparation method of mesoporous apatite nano drug carrier with pH responsive core-shell structure
  • A preparation method of mesoporous apatite nano drug carrier with pH responsive core-shell structure

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specific Embodiment approach 1

[0031] Embodiment 1: The preparation method of a mesoporous apatite nano-drug carrier with a pH-responsive core-shell structure in this embodiment is specifically carried out according to the following steps:

[0032]1. Preparation of F127-calcium pantothenate mixture: Dissolve F127 and calcium pantothenate monohydrate in deionized water, stir at a stirring speed of 250r / min to 400r / min until a clear emulsion is obtained, and obtain F127-calcium pantothenate mixture liquid;

[0033] The mass ratio of F127 described in step 1 to calcium pantothenate monohydrate is 1:(5~10); the mass ratio of F127 described in step 1 to deionized water is 1g:(20~80)mL ;

[0034] 2. Preparation of mesoporous hydroxyapatite nanoparticles: K 2 HPO 4 ·3H 2 O is dissolved in deionized water to give K 2 HPO 4 solution, followed by NH 3 ·H 2 O Mediation K 2 HPO 4 The pH value of the solution is 10-14, and then the pH value is 10-14 K 2 HPO 4 The solution is added dropwise into the F127-calc...

specific Embodiment approach 2

[0046] Specific embodiment two: the difference between this embodiment and specific embodiment one is: the mass ratio of F127 and calcium pantothenate monohydrate described in step one is 2.26:18.43. Other steps and parameters are the same as those in the first embodiment.

specific Embodiment approach 3

[0047] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the volume ratio of the mass of F127 described in step 1 to deionized water is 2.26g:100mL. Other steps and parameters are the same as those in Embodiment 1 or 2.

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Abstract

The invention discloses a preparation method of a mesoporous apatite nano drug carrier with a pH responsive core-shell structure. The invention belongs to the field of biological medical materials and in particular relates to a preparation method of a mesoporous apatite nano drug carrier with a pH responsive core-shell structure in order to solve the problems of small drug carrying capacity and poor carrier water solubility in the prior art. The preparation method comprises the following steps: 1, preparing an F127-calcium pantothenate mixed solution; 2, preparing mesoporous hydroxyapatite nano-particles; 3, performing amination on mesoporous hydroxyapatite; 4, preparing polyacrylic acid-mesoporous apatite nano-particles; and 5, preparing the mesoporous apatite nano drug carrier with the pH responsive core-shell structure. The mesoporous apatite nano drug carrier with the pH responsive core-shell structure, prepared by the method disclosed by the invention, has fast pH responsivity, is large in drug carrying capacity and small in toxic or side effect in an organism, can be applied to clinical treatment of cancers, and has an important application prospect.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a method for preparing a mesoporous apatite nano-medicine carrier with a pH-responsive core-shell structure. Background technique [0002] Cancer is one of the major problems facing the medical field today, and chemotherapy is an indispensable means of cancer treatment. However, traditional chemotherapy has disadvantages such as high toxicity and side effects, low drug bioavailability, and lack of specific recognition, which limit its application and development in cancer treatment. The emergence and development of intelligent response drug controlled release system is expected to solve the problems in chemotherapy. Using nanomaterials as the carrier of anti-tumor drugs to construct a new type of intelligent response system can realize the slow release of drugs and stabilize the blood concentration, thereby reducing its toxic and side effects on patients and impro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/32A61K31/704A61P35/00C01B25/32
Inventor 黄玉东李大龙贺金梅李纪伟尉枫程玮璐吴亚东
Owner HARBIN INST OF TECH
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