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Application of curcumenol and TRAIL in preparation of anti-tumor combined drug

A technology of combining medicine and curcumol, applied in the field of medicine, can solve the problems such as the combined use of curcumitol, and achieves the effects of good prospect of development and utilization, high safety and low concentration of action

Active Publication Date: 2018-12-07
JINAN UNIVERSITY
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  • Claims
  • Application Information

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Problems solved by technology

But so far, there is no relevant report on the combination of curcumol and TRAIL

Method used

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  • Application of curcumenol and TRAIL in preparation of anti-tumor combined drug
  • Application of curcumenol and TRAIL in preparation of anti-tumor combined drug
  • Application of curcumenol and TRAIL in preparation of anti-tumor combined drug

Examples

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Embodiment 1

[0042] Example 1: The combination of curcumol and TRAIL promotes the apoptosis of TRAIL-resistant human lung adenocarcinoma cell lines A549 and H1299

[0043] (1) First, human lung adenocarcinoma cell lines A549 and H1299 (purchased from the cell bank of the American Standard Biological Collection) resistant to TRAIL (Tumor Necrosis Factor-related Apoptosis Inducing Ligand) were selected as research objects, and carried out separately TRAIL (purchased from Peprotech) treatment, A549 and H1299 cells were treated with 100ng / mL, 150ng / mL and 200ng / mL TRAIL respectively, with no treatment as blank control (NC), WST-1 (purchased from Bi Yuntian) to detect cell proliferation. The result is as figure 1 As shown, the concentration below 200ng / mL has no inhibitory effect on the two cell lines.

[0044](2) Curcumol, another object of this study, was purchased from Chengdu Mansite Biotechnology Co., Ltd. with a purity of 99.76%. In order to detect the toxicity of curcumitol to lung ca...

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Abstract

The invention discloses an application of curcumenol and TRAIL in preparation of an anti-tumor combined drug. The application finds that curcumenol is capable of sensitizing TRAIL-tolerant tumor cellsunder the concentration without cytotoxicity and enhancing the induction effect of TRAIL to cell apoptosis. The application further finds that the molecular mechanism for curcumenol to sensitize theTRAIL-tolerant tumor cells is that curcumenol is capable of promoting the up-regulation of the expression of a receptor DR5 of TRAIL so as to enhance the induction effect of TRAIL to cell apoptosis, so that curcumenol can be taken as a sensitizing agent for TRAIL-tolerant lung cancer cell strains. Besides, the application further finds that by virtue of the combined use of curcumenol and TRAIL, the action concentration of TRAIL can be decreased, and the TRAIL-tolerant tumor cells can be well killed. Therefore, curcumenol and TRAIL can be simultaneously taken as an effectively lung cancer treatment scheme and has wide application prospects in the treatment of lung cancer.

Description

technical field [0001] The invention belongs to the technical field of medicine, and particularly relates to the application of curcumol and TRAIL in the preparation of antitumor combined medicine. Background technique [0002] Lung cancer is a cancer with high incidence in the world today, which seriously threatens human life and health. At present, the overall treatment effect of lung cancer is still not optimistic, and designing effective drug treatment strategies for tumor drug resistance has become an urgent research issue. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has the characteristics of selectively killing most tumor cells without obvious cytotoxicity to normal human cells. As early as 2005, my country approved recombinant human TRAIL to enter clinical research. But the clinical effect is not ideal, lung cancer cells are less sensitive to TRAIL treatment and appear to be resistant. [0003] Although some tumor cells are resistant to TRAIL at...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61P35/00A61K31/352
CPCA61K31/352A61K38/177A61P35/00A61K2300/00
Inventor 何庆瑜张静汪洋周烨
Owner JINAN UNIVERSITY
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