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Microbiological coverting product of curcumenol, use and preparation thereof

A technology for microbial transformation and transformation products, applied in the field of medicine, can solve problems such as undeveloped

Inactive Publication Date: 2005-10-12
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, it has not been developed into a clinical drug

Method used

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  • Microbiological coverting product of curcumenol, use and preparation thereof
  • Microbiological coverting product of curcumenol, use and preparation thereof
  • Microbiological coverting product of curcumenol, use and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1: Take 500 mg of the substrate curcumol, dissolve it and add it to the microbial fermentation broth that has been cultured for 2 days, and then take off the shaker flask after continuing to cultivate for 5 days. The fermentation broth was suction filtered to remove mycelia, the filtrates were combined, concentrated to a small volume, extracted three times with an equal volume of ethyl acetate, and the extracts were combined and concentrated to dryness to obtain 1.2 g of crude extract. Dissolve the extract with methanol, stir in 3g of 100-140 mesh silica gel, evaporate the solvent, and wait for sample loading. Take 50g of 200-300 mesh silica gel, wet-pack the column, and then add the processed sample for column chromatography. Elution was carried out with a cyclohexane:acetone gradient (100, 50:1, 25:1, 20:1, 10:1, 5:1). 130 mg (yield: 26%) of colorless crystals were obtained in the 10:1 elution fraction, which was the conversion product.

Embodiment 3

[0039] Take 50g of 3β-hydroxycurcumol, add 160g of fine starch powder, mix evenly with the method of equal increase, use 80% ethanol to make granules, dry, granulate, mix evenly, add 4g of fossil powder, 1.6g of magnesium stearate Tablet pressing (1000 tablets), twice a day, one tablet each time.

Embodiment 4

[0041] Get 100g of 3βhydroxycurcumol, add 200g of fine starch powder, 10g of fossil powder, and 5g of magnesium stearate to make granules, dry, and pack into capsules (2000 capsules), twice a day, one capsule each time.

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PUM

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Abstract

A process of preparing 3 beta- hydroxy curcumenol compound of curcumenol which could be used to prepare resisting virus medicine. Strain is Aspergillus niger(AS3.739), extract product in fermented solution using acetic ester. Separate the product using silica gel chromatography.

Description

Technical field: [0001] The invention relates to the technical field of medicine, in particular it is a microbial conversion product of curcumol and its medicinal use and preparation method. Background technique: [0002] Viruses, as a source of pathogenicity, have always been the focus of pharmaceutical researchers. Because of its strong infectivity to host cells, its damage is irreversible and difficult to completely eliminate, it poses a serious threat to human health. Curcuma is a perennial herb of Zingiberaceae, also known as "Pengzezhu" and "Mountain Turmeric", and its rhizome is used in traditional Chinese medicine. The name of the compendium is Pung Omao, which is included in the Aroma Department of the Herb Department. This product is the dried rhizome of Curcuma phaeocaulisValeton, Curcuma kwangsiensis S.G..Lee et C.F.Liang or Curcuma wenyujin Y.H.Chen et C.Ling. It has been believed to have the effects of promoting qi, breaking blood, eliminating accumulation an...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P31/12C07D493/08C12P17/18
Inventor 邱峰姚新生张卉曲戈霞
Owner SHENYANG PHARMA UNIVERSITY
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