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Medicine composition for preventing and treating senile dementia

A composition and senile technology, applied in drug combination, drug delivery, pharmaceutical formulation, etc., can solve problems such as missed treatment and intervention opportunities, and achieve the effect of increasing the number of neurons, improving learning and memory ability, and improving synaptic plasticity

Inactive Publication Date: 2008-04-30
BEIJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because people think it is normal for the elderly to be forgetful, more than 90% of the elderly patients with cognitive impairment are not detected in the early stage, and the best time for treatment and intervention is missed. Therefore, the existing drugs and treatment methods cannot satisfy people The clinical demand for drugs that can effectively improve brain cognitive dysfunction and prevent and treat senile dementia is becoming more and more urgent

Method used

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  • Medicine composition for preventing and treating senile dementia

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0028] Experimental Example 1 Experimental Study on Improving the Learning and Memory Abilities of Rats with Cognitive Impairment and Rapid Brain Aging

[0029] 1. Materials and methods

[0030] 1.1 Research object

[0031] 10 healthy SAMR 18-month-old mice, half male and half male, and 80 SAMP 8-year-old mice were divided into model group (SHAMP 8); Turmeric (A); Ginkgo biloba (B); Polygala (C); Turmeric + Ginkgo Leaf (D); Turmeric + Polygala (E); Ginkgo + Polygala (F); Turmeric + Ginkgo + Polygala (G) treatment group. Animals were provided by the Animal Center of the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine. Method and route of administration: The dosage is body weight turmeric N.mg·kg -1 , Ginkgo biloba 2N.mg·kg -1 , Polygala 3N.mg·kg -1 ; Turmeric+Ginkgo biloba (D), Curcuma+Polygalae (E), Ginkgo biloba+Polygalae (F) treatment groups are to get 1 / 2 of the medicine of the single component treatment group and deploy into a volume eq...

experiment example 2

[0052] Experimental Example 2 Observation of Drug Effects on Aβ 25-35 Influence experiment of cell count in damaged cell model

[0053] 1. Research object

[0054] 10 healthy SAMR 18-month-old mice, half male and half male, and 80 SAMP 8-year-old mice were divided into model group (SHAMP 8); Turmeric (A); Ginkgo biloba (B); Polygala (C); Turmeric + Ginkgo Leaf (D); Turmeric + Polygala (E); Ginkgo + Polygala (F); Turmeric + Ginkgo + Polygala (G) treatment group. Animals were provided by the Animal Center of the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine. Method and route of administration: The dosage is body weight turmeric N.mg·kg -1 , Ginkgo biloba 2N.mg·kg -1 , Polygala 3N.mg·kg -1 ; Turmeric+Ginkgo biloba (D), Curcuma+Polygalae (E), Ginkgo biloba+Polygalae (F) treatment groups are to get 1 / 2 of the medicine of the single component treatment group and deploy into a volume equal to that of the single component treatment group; Oral l...

experiment example 3

[0070] Experimental Example 3 Observation of Drug Effects on Aβ 25-35 Effects of cell morphology on damaged cell models

[0071] Preparation of research objects and cell models is the same as in Experimental Example 2

[0072] SY5Y cells were divided into 1 × 10 4 Inoculated in 35mm petri dishes, and replaced with serum-free medium when the proliferation reached 40-50%, divided into control group and model group. The model group added Aβ 25umol L -1 , the control group was added an equal volume of MEM. 37°C, 5% CO 2 Incubate for 24 hours in the incubator. Then absorb the culture medium, wash with PBS three times, and perform Wright's staining. Randomly select 60 cells from each group, and use HPIAS-1000 high-definition color graphic report analysis system and medical image computer processing system to measure the length of cell processes and cell bodies. Area (expressed in total number of pixels).

[0073] SY5Y cells were divided into 1 × 10 4 Inoculated in 70mm cultu...

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Abstract

The invention relates to a medication composition and a process for preparation the invention which is for improving cerebral cognitive function disorder, preventing and curing senile dementia. The medication composition of the invention is composed of curcuma, ginkgo leaf and thinleaf milkwort root-bark which are prepared by the techniques of weighting, drying, crashing, marinating, poaching, ethanol extracting, condensing, merging and the like. The medication composition of the invention has the effects of opening the key to the mind, refreshing the brain, nourishing heart, invigorating the circulation of blood, recuperating yin and yang, and resisting senescence, which is capable of improving study memorizing ability, and overcoming cerebral cognitive function disorder, thereby preventing and curing senile dementia.

Description

field of invention [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a medicinal composition for preventing and treating senile dementia and a preparation method thereof. Background technique [0002] Alzheimer's disease (AD) is a degenerative disease of the central nervous system mainly characterized by progressive cognitive impairment and memory impairment. With the aging of the world's population, its incidence rate is getting higher and higher, and its impact on the quality of human life and even the threat to survival are becoming more and more obvious. [0003] For multifactorial diseases such as AD, single-target therapy is difficult to achieve satisfactory results. Under the circumstances that the etiology and pathogenesis of AD are poorly understood and breakthrough progress cannot be made in the near future, although there are controversies about the etiology of AD and other issues, the Its treatment ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61P25/28
Inventor 张占军刘振权王永炎李澎胡远皆夏宇杰刘飞张鹏
Owner BEIJING NORMAL UNIVERSITY
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