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Application of momordica polysaccharide to preparation of learning and memory ability improving medicines

A technology of learning and memory ability and balsam pear polysaccharide, applied in the field of medicine, can solve problems such as no literature reports

Active Publication Date: 2016-12-14
XUZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no literature report on the application of bitter gourd polysaccharide in improving learning and memory ability.

Method used

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  • Application of momordica polysaccharide to preparation of learning and memory ability improving medicines
  • Application of momordica polysaccharide to preparation of learning and memory ability improving medicines
  • Application of momordica polysaccharide to preparation of learning and memory ability improving medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1 Effect of bitter gourd polysaccharide on learning and memory ability of rat aging model induced by D-galactose

[0019] 1. Experimental animals

[0020] Male Sprague-Dawley (SD) rats, weighing 240g-270g, clean grade, provided by the Experimental Animal Center of Xuzhou Medical University, experimental animal production license: SCXK (SU) 2010-0003.

[0021] 2. Main reagents

[0022] Bitter gourd polysaccharide: extracted according to the method described;

[0023] D-galactose: purchased from Sangon Bioengineering (Shanghai) Co., Ltd.;

[0024] Piracetam (naofukang): purchased from Jinling Pharmaceutical Co., Ltd. Limin Pharmaceutical Factory.

[0025] 3. Instrument

[0026] Morris water maze (model: XR-XM101-R), ANY-maze animal behavior analysis system.

[0027] 4. Data processing

[0028] SPSS16.0 was used to analyze statistical software, and the experimental data were expressed as mean ± standard deviation (Mean ± SD). Statistical analysis was perform...

Embodiment 2

[0042] Example 2 Effect of bitter gourd polysaccharide on learning and memory ability of rat stroke model

[0043] 1. Establishment, grouping and administration of experimental animal models

[0044]SD rats were randomly divided into blank group, stroke model group, and model administration group, with 30 rats in each group. Due to the large number of rats, the experiment was conducted in two batches: the first batch was the blank group and the stroke model group, and the second batch was the stroke model group and the model administration group.

[0045] Establishment of cerebral artery occlusion suture model (MCAO) in SD rats: after anesthesia by intraperitoneal injection of 20% chloral hydrate, a midline incision was made in the neck, the surrounding tissues were separated, and the common carotid artery (CCA) was exposed and the proximal end was ligated. The external carotid artery (ECA), internal carotid artery (ICA) and pterygopalatine artery were separated at the distal...

Embodiment 3

[0054] Example 3 The improvement of learning and memory ability of normal rats with bitter gourd polysaccharide

[0055] 1. Grouping and administration of experimental animals

[0056] The SD rats were randomly divided into: a normal group (ie, a control group) and an administration group, with 25 rats in each group. Bitter melon polysaccharide dissolved in ddH 2 In O, 200 mg / kg of bitter gourd polysaccharide was administered orally once a day, and the water maze test was performed by intragastric administration for 2 consecutive weeks.

[0057] 2. Water maze experiment results

[0058] Such as Figure 5 As shown in A-D, it can be seen from Figure A that the incubation period of the rats in the normal group and the drug-administered group showed a downward trend during the 5-day positioning and navigation training. Consistent, and the average value of the incubation period on the last day of each group is smaller than that at the beginning of training, suggesting that the ...

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Abstract

The invention discloses application of momordica polysaccharide to preparation of learning and memory ability improving medicines. The influences of momordica polysaccharide to the learning and memory ability of a model of rat ageing induced by D-galactose, the influences of momordica polysaccharide to the learning and memory ability of a model of rat stroke and the influences of momordica polysaccharide to the learning and memory ability of normal rats are studied respectively. It is shown through experiment results that momordica polysaccharide has an effect on improving the learning and memory ability. The application range of momordica polysaccharide is widened, and an experiment basis is provided for the clinical application on the aspect of preparing learning and memory ability improving medicines.

Description

technical field [0001] The invention relates to the application of bitter gourd polysaccharide in the preparation of medicines for improving learning and memory, and belongs to the technical field of medicine. Background technique [0002] Learning and memory ability is one of the basic abilities for human beings to understand the objective world, and it is also an important function of the human brain. At present, due to social competition, the young people are under increased pressure in life and work, and have the phenomenon of learning and memory loss; and a considerable number of elderly people often suffer from learning and memory loss, and even learning and memory loss, in addition to suffering from various senile diseases. obstacle situation. Cerebral infarction, cerebral ischemia, and cerebral hemorrhage caused by cardiovascular and cerebrovascular diseases can also lead to vascular dementia. In addition, learning and memory impairment and even dementia caused by ...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61P25/28
CPCA61K31/715
Inventor 齐素华侯筱宇郭鹏
Owner XUZHOU MEDICAL UNIV
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